Abstract
The antiandrogen agents most frequently used in acne treatment are all systemic and are especially useful in the presence of other signs of peripheral hyperandrogenism, in extensive acne and in any type of acne resistant to conventional treatments. However, they can only be used in women, contraception is essential, they are only suppressive and recurrence occurs after treatment is stopped, and they may cause side effects and drug interactions. Antiandrogens are classified as steroids, which affect the production of androgens, or non-steroids, which have only peripheral effects. The main steroid antiandrogens used in acne treatment are those with diuretic actions (spironolactone), those with progestagenic actions (usually given with estrogen in contraceptive formulations) and estrogens. The main non-steroid agent is flutamide.
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