Abstract
Hair follicles produce hair fibers in a regular cycle. As part of their hair-producing role, hair follicles retain stem cells, promote cell growth and tissue invasion and induce angiogenesis. However, hair follicle function involves more than just hair fiber production. Hair follicles interact closely with the skin immune and neuroendocrine systems, supporting immunosurveilance against pathogens and aiding sensory perception. Hair follicles can also assist in wound healing and skin repigmentation. However, the unique properties of hair follicles can also be detrimental to skin health. Perhaps most significantly, hair follicles may contribute to the development of skin neoplasias. This article reviews the potential role of hair follicles in skin health.
Acknowledgements
Supported by grants from the Canadian Dermatology Foundation (CDF), Canadian Institutes of Health Research (CIHR), National Alopecia Areata Foundation (NAAF) and North American Hair Research Society (NAHRS).