Expression and functionality of Toll-like receptors in the skin: potential implication in skin inflammatory diseases

Abstract

Recent data have demonstrated that Toll-like receptors (TLRs) play a key role in both innate and adaptive immune responses. The human skin is consistently exposed to a wide range of exogenous stimuli and can exhibit anti-infectious properties. The aim of this review is to describe TLRs and assess the expression of TLRs in human epidermis and the function of these receptors within the epidermis under physiological and pathological conditions.

Keywords::

• cutaneous inflammation
• eczema
• psoriasis
• Toll-like receptor

Acknowledgement

The authors are most grateful to Richard Medeiros, Rouen University Hospital Medical Editor, for editing the manuscript.