Abstract
Lynch syndrome, or hereditary nonpolyposis colorectal cancer, predisposes women to an increased risk of gynecologic malignancies. Various preliminary clinical models have been attempted to identify those at-risk. Currently, the Bethesda criteria have the most sensitive guidelines for identifying at risk individuals for genetic testing. Universal screening of patients with colorectal cancer or endometrial cancer has not been found to be cost effective, but introduces the concept of extracolonic cancer as a ‘sentinel cancer’ other than colorectal cancer for hereditary nonpolyposis colorectal cancer. While there is a lack of strong evidence supporting gynecologic surveillance or risk-reducing surgery, they are both considered important options to this high-risk population. Risks and benefits of each strategy should be addressed by gynecologic oncologists.
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.
Notes
CRC: Colorectal cancer; HNPCC: Hereditary nonpolyposis colorectal cancer.
Adapted from Syngal et al.Citation[13].