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Drug Profile

Raloxifene: an agent for breast cancer prevention

Pages 277-285 | Published online: 10 Jan 2014
 

Abstract

On 13 September 2007, raloxifene was approved by the US FDA for reducing the risk of invasive breast cancer in postmenopausal women at high risk of invasive breast cancer and in women with osteoporosis. This approval was the result of the findings from the Multiple Outcomes of Raloxifene Evaluation (MORE) trial and the Study of Tamoxifen And Raloxifene (STAR). MORE, an osteoporosis treatment trial, suggested that raloxifene reduced the incidence of breast cancer in average-risk postmenopausal women with osteoporosis. STAR compared the proven preventive agent tamoxifen with raloxifene, a selective estrogen receptor modulator that had been suggested to have a preventive benefit with fewer side effects. The results of STAR showed that raloxifene is equivalent to tamoxifen in the prevention of invasive breast cancer. Postmenopausal women now have a second option to reduce their risk of invasive breast cancer.

Financial & competing interests disclosure

The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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