Systemic lupus erythematosus, regulatory T cells and pregnancy

Abstract

Systemic lupus erythematosus (SLE) is the most common autoimmune disease affecting women of reproductive age and is associated with poor maternal and fetal outcomes. CD4⁺CD25⁺ Treg cells are a subset of T lymphocytes with potent immunosuppressive activity that play crucial roles in controlling immunological self tolerance. Evidence suggests that they are augmented in pregnancy, especially in the first trimester, suggesting an important role in early placental development. The literature describing Treg cells in SLE is conflicting, but SLE is associated with reduced numbers and functionally defective Treg cells, which may predispose pregnant women with the disease to pregnancy complications. This article discusses the role of Treg cells in SLE and pregnancy, and how these cells may contribute to poor pregnancy outcome in SLE-affected women.

Keywords::

• immune tolerance
• pregnancy
• systemic lupus erythematosus
• T regulatory cells

Financial & competing interests disclosure

All authors are supported by the Manchester Academic Health Sciences Centre and Manchester NIHR Biomedical Research Centre. Clare Tower and Ian N Bruce are also funded by the Manchester Wellcome Trust Clinical Research Facility. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.