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Abstract
Sublingual zolpidem tartrate (SZT) is a sublingual lozenge containing a low dose of the nonbenzodiazepine hypnotic zolpidem tartrate. Pharmacokinetic evaluations suggest that this formulation produces higher drug plasma levels within the first 15–20 min after dosing than the standard oral tablet using only approximately 30% of the standard dose. Published data suggest that SZT is generally safe and effective at rapidly inducing sedation without residual next-day effects, as long as the patient has at least 4 h remaining in bed at the time of administration. SZT is currently being reviewed by the US FDA for potential approval for insomnia characterized by middle-of-the-night awakenings with difficulty returning to sleep.
Financial & competing interests disclosure
Alan Lankford has received research funding from Actelion, Arena, Cephalon, Evotec, GlaxoSmithKline, Lilly, Merck, Neurim, Neurocrine, Neurogen, Organon, Pfizer, Respironics, Sanofi-Aventis, Schering-Plough, Sepracor, Somaxon, Takeda, Transcept and Vanda. He also acts as a consultant/Advisory Board member for Actelion, Cephalon, Concert, GlaxoSmithKline, Neurocrine, Neurogen, Ovation, Pfizer, Somaxon and Transcept, and is on the Speakers Bureau for Jazz Pharmaceuticals and Somaxon. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.