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Expert Review of Clinical Pharmacology Volume 4, 2011 - Issue 3
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Drug Profile

Methylphenidate transdermal system: clinical applications for attention-deficit/hyperactivity disorder

Josephine Elia The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA; University of Pennsylvania, 3451 Walnut Street, Philadelphia, PA 19104, USA;[email protected]
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Zoe Wilson The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA; The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA
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Lilly Sehgal La Porta The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA; The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA
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Sibel A Algon The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA; The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA
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Matthew L Prowler The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA; The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA
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Shanique T Cartwright The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA; The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA
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Patricia A McKenna The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA; The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA
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Seth Laracy The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA; The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA
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Toshinobu Takeda The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA; Ryukoku University, Kyoto, Japan; The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA; Ryukoku University, Kyoto, Japan
&
Karin Borgmann-Winter The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA; University of Pennsylvania, 3451 Walnut Street, Philadelphia, PA 19104, USA; The Children’s Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA; University of Pennsylvania, 3451 Walnut Street, Philadelphia, PA 19104, USA
 show all
Pages 311-328 | Published online: 10 Jan 2014
 
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Abstract

The methylphenidate transdermal system (MTS) provides a novel method of delivery for methylphenidate, a well-studied and effective medication for attention-deficit/hyperactivity disorder. The MTS achieves two major goals. First, the delivery system allows for administration throughout the day with a single patch, thus improving adherence. Second, it is the first approved attention-deficit/hyperactivity disorder medication that is not administered orally, thus bypassing gastrointestinal absorption and first-pass metabolism through the enteric circulation. In this article, we review the current data on MTS, including preclinical, clinical and post-marketing studies, and compare efficacy and tolerability to currently available treatments.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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