42
Views
0
CrossRef citations to date
0
Altmetric
Key Paper Evaluation

Increased fracture risk in patients treated with thiazolidinediones: the role of abnormal bone turnover

Pages 177-180 | Published online: 10 Jan 2014
 

Abstract

Evaluation of: Zinman B, Haffner SM, Herman WH et al. Effect of rosiglitazone, metformin, and glyburide on bone biomarkers in patients with Type 2 diabetes. J. Clin. Endocrinol. Metab. 95(1), 134–142 (2010).

Until recently, patients with Type 2 diabetes were thought to be relatively protected against osteoporosis by their high BMI. However, recent epidemiological data suggest that fracture risk is increased in diabetic patients. Additionally, use of thiazolidinedione antidiabetic medications (rosiglitazone and pioglitazone) was unexpectedly found to be associated with an increased risk of fractures. The paper under evaluation in this article examines changes in biochemical markers of bone turnover in subjects within the clinical trial that first raised the issue of fractures. The main finding was a significant increase in bone resorption with rosiglitazone. This conclusion conflicts with other studies examining the effects of thiozolidinediones on bone and, by itself, is unlikely to fully explain the increased fracture risk seen with these drugs.

Financial & competing interests disclosure

Mark Cooper is supported by an unrestricted Clinician Scientist Fellowship from GlaxoSmithKline, the manufacturer of rosiglitazone. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 99.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 608.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.