48
Views
5
CrossRef citations to date
0
Altmetric
Clinical Trial Report

The GetGoal clinical trial program of lixisenatide, a once-daily GLP-1 receptor agonist

, &
Pages 513-525 | Published online: 10 Jan 2014
 

Abstract

Lixisenatide is a human glucagon-like peptide-1 receptor agonist for the once-daily treatment of Type 2 diabetes mellitus (T2DM). Lixisenatide is based on the structure of exendin-4 (1-39) with C-terminal modification. Clinical trials involving patients with T2DM have provided evidence for improved glucose tolerance, weight loss and lowered hemoglobin A1c (HbA1c) causing a significantly higher percentage of patients to achieve target HbA1c compared with placebo. This article reviews the clinical pharmacology of lixisenatide as well as the GetGoal clinical trial program that aims to make lixisenatide available for the treatment of patients with T2DM.

Financial & competing interests disclosure

Filip K Knop has served as a consultant for AstraZeneca and Eli Lilly. Tina Vilsbøll has served as a consultant for Novo Nordisk, Merck Sharp Dome and Eli Lilly. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 99.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 608.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.