26
Views
3
CrossRef citations to date
0
Altmetric
Drug Profile

Recombinant human FSH and recombinant human LH in a 2:1 ratio combination: a new tool for ovulation induction

Pages 491-498 | Published online: 10 Jan 2014
 

Abstract

Hypogonadotrophic hypogonadism is a dysfunction characterized by the lack of gonadotrophin production and, therefore, attenuated or stopped gonadal action, which leads to anovulation and subsequent infertility. A new fixed combination of recombinant human FSH and recombinant human LH in a 2:1 ratio has recently been developed. Pharmacological studies show bioequivalence with the parameters of the separated compounds. Phase II/III studies have demonstrated high efficiency and safety for inducing ovulation in these patients. Studies analyzing the potential role of recombinant human luteinizing hormone supplement in normovulatory patients following ovarian stimulation for IVF–embryo transfer under pituitary downregulation, suggest a benefit in patients over 35 years old and/or with low response to stimulation with recombinant human follicle-stimulating hormone administered alone. However, further studies are needed to further analyze this issue.

Financial & competing interests disclosure

The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Log in via your institution

Log in to Taylor & Francis Online

There are no offers available at the current time.

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.