Abstract
Evaluation of: Quddus MR, Sung CJ, Zhang C, Lawrence WD. Minor serous and clear cell components adversely affect prognosis in ‘mixed-type’ endometrial carcinomas: a clinicopathologic study of 36 stage-I cases. Reprod. Sci. 17(7), 673–678 (2010).
Endometrioid adenocarcinomas of the endometrium occasionally display a small proportion of serous or clear-cell adenocarcinoma, two of the high-grade histotypes. Since the adjuvant management for patients with low-grade, early-stage endometrioid adenocarcinoma is so different from the management of their counterparts with the serous or clear histotypes, this situation poses a significant conundrum. The article under evaluation compared the overall survival between patients with stage I endometrioid adenocarcinomas with a minor serous or clear-cell component, and an age- and stage-matched control group comprised of pure endometrioid, clear-cell and serous adenocarcinomas. Preliminary analyses suggest that these minor components, even in small proportions, may adversely impact the overall survival of patients with low-grade, stage I endometrioid adenocarcinoma, but a larger scale analysis that would allow for the accrual of sufficient patients to achieve statistical power is required.
Financial & competing interests disclosure
The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
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