Abstract
As the maternal age increases, and with the emergence of more effective therapies, clinicians are seeing more women with rheumatoid arthritis (RA) contemplating pregnancy. Newer evidence shows that RA remains active in pregnancy; active RA correlates well with adverse obstetric outcomes. Preeclampsia is common, as are operative and preterm deliveries in women with RA. Women with active RA are also more likely to have babies of lower birthweight. This article discusses the latest findings on population-based studies of women with RA and the various drugs used to manage RA. Controversies regarding biological agents are addressed, and guidance on prepregnancy counseling, antenatal care, delivery and breastfeeding based on our experience are detailed here. With appropriate prepregnancy counseling and planning, most women with RA can safely fall pregnant and continue to enjoy good disease control in pregnancy and the postpartum interval.
Financial & competing interests disclosure
MC Soh was supported by the Rose-Hellaby Medical Scholarship from New Zealand. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.