Abstract
Age-related macular degeneration (AMD) is a multifactoral disorder occurring in individuals with the genetic predisposition. This article summarizes the AMD-susceptibility single nucleotide polymorphisms (SNPs) in different ethnicities, and the effect of SNPs on the efficiency of AMD therapies. The data show that the genes conferring risk to AMD in Caucasian population are often associated with AMD in other ethnicity groups. However, the strength of the association or particular SNPs within the gene may differ. The most global AMD alleles across ethnic groups are SNPs at the complement factor H and PLEKHA1/LOC387715/HtrA1. Individuals carrying AMD allele(s) might have an altered response to current available therapies. Alleles that alter the AMD therapy effects are not necessarily AMD-susceptibility SNPs.
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.