Role of proteomic technologies in understanding risk of arterial thrombosis

Abstract

Arterial thrombosis is a pivotal event in the development of cardiovascular diseases. Plasma and cellular proteins have the potential to influence thrombus morphology and function. This review summarizes the latest studies to use proteomic technologies to characterize the cellular and plasma components involved in arterial thrombosis, with a view to understanding the pathogenesis and treatment of acute cardiovascular diseases. Proteomic approaches have been extensively used to profile the proteome of endothelial cells, leukocytes, vascular smooth muscle cells, platelets and plasma in the search for risk factors for cardiovascular disease; however, further work is required to validate the direct contribution of these proteins to arterial thrombosis.

Keywords::

• arterial thrombosis
• cardiovascular disease
• endothelial cell
• fibrin
• leukocyte
• plasma
• platelet
• proteomics
• vascular smooth muscle cell

Financial & competing interests disclosure

Victoria R Polkinghorne is funded by a Medical Research Council DTA PhD studentship (UK). Verena Schroeder is funded by a fellowship from the Swiss Foundation for Grants in Biology and Medicine and the Swiss National Science Foundation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.