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Expert Review of Anticancer Therapy Volume 11, 2011 - Issue 9
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Key Paper Evaluation

Determination of cut-offs for circulating tumor cell measurement in metastatic cancer

Jimmy Jacob Dept. of Oncology, Dept. of Surgery and Cancer, 5th Floor, MRC Cyclotron Building, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK; Dept. of Oncology, Dept. of Surgery and Cancer, 5th Floor, MRC Cyclotron Building, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
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Jonathan Krell Dept. of Oncology, Dept. of Surgery and Cancer, 5th Floor, MRC Cyclotron Building, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK; Dept. of Oncology, Dept. of Surgery and Cancer, 5th Floor, MRC Cyclotron Building, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
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Leandro Castellano Dept. of Oncology, Dept. of Surgery and Cancer, 5th Floor, MRC Cyclotron Building, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK; Dept. of Oncology, Dept. of Surgery and Cancer, 5th Floor, MRC Cyclotron Building, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
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Long R Jiao HPB Surgical Unit, Dept. of Surgery and Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK; HPB Surgical Unit, Dept. of Surgery and Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK
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Justin Stebbing Dept. of Oncology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, 1st Floor, E Wing, Fulham Palace Road, London, W6 8RF, UK; Dept. of Oncology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, 1st Floor, E Wing, Fulham Palace Road, London, W6 8RF, UK
&
Adam E Frampton HPB Surgical Unit, Dept. of Surgery and Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK;[email protected]
Pages 1345-1350 | Published online: 10 Jan 2014
 
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Abstract

Evaluation of: Pierga JY, Hajage D, Bachelot T et al. High independent prognostic and predictive value of circulating tumor cells compared with serum tumor markers in a large prospective trial in first-line chemotherapy for metastatic breast cancer patients. Ann. Oncol. DOI: 10.1093/annonc/mdr263 (2011) (Epub ahead of print).

The metastatic transformation of epithelial tumors progresses through various steps leading to the generation of circulating tumor cells (CTCs). Measurement of CTCs in the peripheral blood is being increasingly recognized as a promising tool in breast oncology. Several studies have evaluated the prognostic significance of CTCs in newly diagnosed metastatic breast cancer (MBC) patients. The IC 2006-04 was a high-powered, prospective, multicenter, observational study conceived to assess CTC changes in women with MBC treated with first-line chemotherapy. Levels ≥5 CTCs/7.5 ml blood at baseline and before the second cycle of treatment were independent prognostic factors associated with shorter progression-free and overall survival. This study provides further level II evidence for the clinical and prognostic value of CTCs in MBC, confirming data from earlier small studies. It also provides proof that CTCs should be investigated in ongoing interventional trials to see if better patient outcomes can be attained by altering treatment based on CTC levels.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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