![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
Evaluation of: Ko MA, Zehong G, Virtanen C et al. miRNA expression profiling of esophageal cancer before and after induction chemoradiotherapy. Ann. Thorac. Surg. 94(4), 1094–1103 (2012).
Most patients undergoing surgery for esophageal cancer are treated before surgery with chemotherapy and radiotherapy. However, some tumors respond poorly to these treatments. The article under evaluation profiled miRNA levels in esophageal cancers from patients who did respond to chemoradiotherapy versus those who did not. A large number of miRNAs were differentially expressed between responders versus nonresponders, and patients with either decreased miR-135b or increased miR-145 expression in cancer tissue had improved disease-free survival. Although this study has several limitations, including a mixed cohort of patients with adenocarcinoma and squamous cell carcinoma, and the absence of a validation set of patients, the results do suggest that a miRNA profiling approach may be able to circumvent one of the primary challenges for biomarker development, molecular heterogeneity.
Keywords::
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.