Pulmonary hypertension in women

Abstract

Female predominance in pulmonary arterial hypertension (PAH) has been known for several decades and recent interest in the effects of sex hormones on the development of disease has substantially increased our understanding of this epidemiologic observation. Basic science data suggest a beneficial effect of estrogens in the pulmonary vasculature both acutely and chronically, which seems to contradict the known predilection in women. Recent human and rodent data have suggested that altered levels of estrogen, differential signaling and altered metabolism of estrogens in PAH may underlie the gender difference in this disease. Studies of the effects of sex hormones on the right ventricle in animal and human disease will further aid in understanding gender differences in PAH. This article focuses on the effects of sex hormones on the pulmonary vasculature and right ventricle on both a basic science and translational level.

Keywords::

• estrogen
• gender
• pulmonary arterial hypertension
• pulmonary hypertension
• pulmonary vasculature
• sex hormones

Financial & competing interests disclosure

Anna R Hemnes has received grant support from Actelion and the NIH (1 K08 HL093363). She has served on the advisory boards and speakers bureaus for Actelion and Gilead. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Notes

PAH: Pulmonary arterial hypertension.

Modified from [1].