Abstract
Evaluation of: Nagy E, Andersson DC, Caidahl K et al. Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts. Circulation DOI: 10.1161/CIRCULATIONAHA.110.966846 (2011) (Epub ahead of print).
Understanding the exact pathophysiological mechanism of degenerative aortic stenosis is important in order to develop new treatment modalities and prevent progression of the disease. Recently, most of the inflammatory markers in association with aortic stenosis have been described. The authors of the paper under evaluation investigate the effects of the 5-lipoxygenase pathway on aortic valve stenosis and correlation with severity of stenosis. In this article, we suggest that the 5-lipoxygenase pathway is one of the possible factors in the development of aortic stenosis.
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.