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Abstract
Evaluation of: Lubezky N, Loewenstein S, Ben-Haim M et al. MicroRNA expression signatures in intraductal papillary mucinous neoplasm of the pancreas. Surgery doi:10.1016/j.surg.2012.11.016 (2013) (Epub ahead of print).
Pancreatic cysts are now being detected more frequently owing to increased recognition and the liberal use of cross-sectional imaging. There is a spectrum of pancreatic cystic lesions ranging from the completely benign inflammatory to the highly malignant. Pancreatic cystic tumors, especially those with a mucinous epithelial lining such as the intraductal papillary mucinous neoplasms (IPMNs), have the potential to become malignant. The evaluated paper provides further evidence for miRNAs as diagnostic biomarkers for detecting dysplastic and malignant change in IPMNs, which may be useful for future clinical decision making. IPMNs of varying degrees of dysplasia, as well as IPMN with carcinoma, pancreatic ductal adenocarcinoma and normal pancreas samples were examined by microarray. Upregulation of miR-21, miR-155 and miR-708 was found to occur during IPMN malignant transformation. Here, the authors evaluate the published miRNA profiles of premalignant pancreatic lesions in order to consolidate these data.
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.