Genome-wide investigation of rare structural variants identifies VIPR2 as a new candidate gene for schizophrenia

Abstract

Evaluation of: Vacic V, McCarthy S, Malhotra D et al. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature DOI: 10.1038/nature09884 (2011) (Epub ahead of print).

Research has shown that structural variation in the human genome, including rare copy number variations (CNVs), contributes to genetic susceptibility to psychiatric diseases, such as schizophrenia, a devastating complex disorder with a high genetic load. The study by Vacic et al. applied a genome-wide approach to detect novel, rare and highly penetrant CNVs. Detailed analysis of microduplications at 7q36.3 revealed that the neuropeptide receptor gene VIPR2 confers a significant risk for schizophrenia. This suggests that altered vasoactive intestinal signaling contributes to the genetic etiology of this disorder. This article recapitulates the findings of this study within the context of current knowledge of CNVs in the field of psychiatric disease.

Keywords::

• CNV
• copy number variation
• microduplication
• schizophrenia
• VIPR2

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.