Lung epithelial wound healing in health and disease

Abstract

Physiological lung epithelial wound repair is a complex, highly orchestrated process presenting numerous points where dysregulation may occur, leading to the development of several pulmonary disorders. Current studies are limited by a lack of relevant lung injury models, with much work relying on other organ models such as the skin or in vitro cultures. However, much promising investigative work is being undertaken, some of which is described in this article. This article attempts to describe the processes required to heal a severe wound to the airway epithelium, characteristic of several chronic pulmonary disorders, highlighting areas where dysregulation may occur, which in turn leads to the development or continuation of a disease state.

Keywords::

• dysregulation
• epithelial
• lung
• models
• repair
• wound

Financial & competing interests disclosure

Andrew J Fisher is supported by a research grant from the Medical Research Council UK (G0700861). Aaron Gardner is supported by a PhD studentship from the Medical Research Council UK. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.