Treatment challenges in the management of moderate-to-severe plaque psoriasis – role of secukinumab

Abstract

Psoriasis is a chronic inflammatory skin disease that has a negative impact on psychosocial well-being and cardiometabolic health. Treatment options for moderate-to-severe psoriasis have expanded with the development of interleukin-17 (IL-17) inhibitors, the first of which is now available – secukinumab. Secukinumab is a fully human monoclonal immunoglobulin G1 κ antibody that selectively inhibits the ligand IL-17A. In head-to-head studies, it is more effective than etanercept and ustekinumab, particularly in achieving Psoriasis Area and Severity Index (PASI) 90/100 and achieving PASI 50/75 as early as week 4. No head-to-head trials are available for comparison of adalimumab to secukinumab. Significant improvement in health care-related quality of life was also observed using the dermatology quality index in clinical studies. Safety data for secukinumab is comparable to available biologics. Specific safety concerns for the use of secukinumab include its use in patients with inflammatory bowel disease, reversible transient neutropenia, in those with a latex allergy, and the occurrence of mild to moderate oral or genital candidiasis. Secukinumab is an effective and safe treatment option that achieves high clearance rates up to PASI 90 and 100 as monotherapy in cases of moderate-to-severe psoriasis. It may be particularly helpful in patients with psoriasis who have formed antidrug antibodies or failed other biologic agents and in patients with psoriatic arthritis or ankylosing spondylitis.

Keywords:

• psoriasis
• biologics
• secukinumab
• inflammation
• quality of life

Introduction

Psoriasis is a common chronic inflammatory skin disease that occurs in ~3% of the US general population.¹ The impact of psoriasis on patients’ lives can be devastating, as patients suffer from social stigmatization, low self-esteem, high medical costs in the setting of reduced work productivity, and ultimately a decreased quality of life (QOL).^2,3 Moderate-to-severe psoriasis has also been associated with multiple comorbidities including psoriatic arthritis, and cardiometabolic diseases such as obesity, hypertension, dyslipidemia, and diabetes mellitus.^4,5

The treatment of moderate-to-severe psoriasis, or skin involving more than 10% body surface area (1% body surface area is equivalent to one whole hand), requires systemic agents.⁶ Previously, these patients were restricted to oral agents such as cyclosporine, methotrexate, and acitretin; the use of these agents is limited by generalized immune suppression and kidney and liver toxicity.⁶ Although phototherapy remains an efficacious treatment option, its use has been limited by cost, access, and inconvenience; the use of home ultraviolet therapy decreases these obstacles, yet remains underutilized. The treatment options for moderate-to-severe psoriasis have expanded the production of biologic agents designed to inhibit specific immune cell targets thought to play a role in the pathophysiology of psoriasis.

Initially thought to be a T-helper subset 1 (Th1)-mediated disease, tumor necrosis factor-alpha (TNFα) neutralization/blockade by biologic agents etanercept, infliximab, and adalimumab was pursued for the treatment of psoriasis and psoriatic arthritis.^7,8 Ustekinumab, which blocks interleukin-12 (IL-12) and IL-23 by the common p40 subunit, provided an important link between IL-23 and the discovery of the downstream T-helper subset 17 (Th17) and IL-17 pathway.^9–11 IL-23 acts to maintain and promote the growth of Th17 cells responsible for the release of IL-17A, a potent member of the IL-17 family of cytokines that plays a significant role in the pathogenesis of psoriasis.¹¹ This discovery has led to the production of targeted biologic agents that directly inhibit these downstream products more proximal to the keratinocyte. The first US Food and Drug Administration (FDA) approved anti-IL-17 biologic is secukinumab. Other IL-17 inhibitors, such as brodalumab and ixekizumab, are undergoing further Phase III clinical trials.^12,13 This review will discuss the role and utility of secukinumab in clinical practice.

Methods

We reviewed the results of published Phase II and Phase III clinical trials for secukinumab. For additional resources, we conducted an English literature search with search terms “secukinumab” and “psoriasis” using PubMed to locate additional research articles reviewing secukinumab in other disease states as well as psoriasis. We also reviewed in-text citations within these resources to identify other additional articles. Articles were screened for relevance by reviewing the title and abstract.

Review of pharmacology, mode of action, and pharmacokinetics of secukinumab

Secukinumab (Cosentyx^™; Novartis Pharma AG, Basel, Switzerland) is a fully human monoclonal immunoglobulin G1 κ antibody that selectively inhibits the ligand IL-17A and its downstream effects by preventing it from binding to the IL-17 receptor.¹⁴ This inhibition prevents the activation of keratinocyte proliferation, release of further inflammatory cytokines, neutrophil activation, and angiogenesis.¹¹

The bioavailability of secukinumab was ~77%, with peak concentrations being achieved 5–6 days after a single subcutaneous dose (150 or 300 mg). With monthly dosing as recommended, steady state is achieved within 20 weeks. The volume of distribution is 7.1–8.6 L for a single intravenous dose, representing the limited distribution to peripheral compartments. Microperfusion studies of the dermis illustrated the distribution of secukinumab to dermal interstitial fluid.¹⁵ Similar to the metabolism of endogenous immunoglobulins, secukinumab is metabolized intracellularly into small peptides and amino acids with a half-life elimination of ~27 days. Due to intracellular catabolism, the potential for drug interactions with secukinumab is low.

No dose adjustments for geriatric populations or those with renal or hepatic impairment are recommended.¹⁶ Patients are still able to mount a protective antibody response to inactivated or nonlive vaccinations while actively undergoing therapy with secukinumab.¹⁷

Typically, total serum IL-17A level (free IL-17A plus IL-17A complexed with secukinumab) rises after administration of secukinumab and declines near the end of the treatment period due to slow clearance of the IL-17A/secukinumab complex. The clinical improvement of psoriatic lesions was paired with immunohistochemical studies of lesional biopsies. At baseline, lesional biopsies from psoriatic plaques showed higher levels of IL-17A compared to lesional biopsies from healthy volunteers. After treatment and improvement in the Psoriasis Area and Severity Index (PASI), lesional biopsies from psoriatic plaques showed decreased keratinocyte parakeratosis and thickness as well as decreased numbers of innate immune cells and CD3+ T-cells.

Secukinumab dosing and efficacy

To establish the dosing, efficacy, and safety of secukinumab, four Phase II and six Phase III trials were completed. Relevant Phase III trial results are given in Table 1.

Table 1 Secukinumab Phase III trials efficacy and safety

Trial	Design	PASI 75 at week 12	PASI 90 at week 12	PASI 100 at week 12	Conclusion
FIXTURE (2011–2013), Langley et al,^Citation26 52 weeks, N=1,306	Arms: secukinumab 300 mg (S300) or secukinumab 150 mg (S150) S300 vs S150 (weekly injections then monthly) vs etanercept (E) (50 mg 2×/wk for 12 weeks then 1×/wk until week 48) vs PL MC, DB, PG, PC, R	S300 – 77.1% S150 – 67% E – 44% PL – 4.9% P<0.0001	S300 – 54.2% S150 – 41.9% E – 20.7% PL – 1.5% P<0.0001	S300 – 24.1% S150 – 14.4% E – 4.3% PL – 0% P<0.0001	Secukinumab was superior to etanercept and placebo up through week 52
	AEs:
	Common: nasopharyngitis, headache, URI, diarrhea
	Any AEs rates similar in induction phase between all groups
	Any AEs, maintenance phase, per 100 patient-years: 252 in S300, 236.4 in S150, 243.3 in E, and 329.7 in PL
	Similar AE rates between secukinumab and etanercept: no apparent differences in types of SAEs
	Serious infections per 100 patient-years: 1.1 in S300, 0.6 in S150, 1.2 in E, and 0.3 in PL
	Malignancy per 100 patient-years: 0.6 in S300, 0.4 in S150, 0.6 in E, and 0.3 in PL
	3 MACE events: 1 CVA and 1 MI (same subject) in S150 group and 1 MI in PL group
	Less injection site reactions than etanercept
	Candida infections: S300 4.7% (mild to moderate), S150 2.3% (mild to moderate), E 1.2% (two had severe infections)
	Grades 1 and 2 neutropenia. Grade 3 neutropenia in one patient (also while on PL)
	1 unrelated death due to suicide during the screening process
	ADA were found in 4 of 980 patients, none were neutralizing
ERASURE (2011–2013), Langley et al,^Citation26 52 weeks, N=738	Arms: S300 vs S150 vs PL Weekly for 1 month then monthly injections until week 48 MC, DB, PG, PC, R	S300 – 81.6% S150 – 71.6% PL – 4.5% P<0.0001	S300 – 59.2% S150 – 39.1% PL – 1.2% P<0.0001	S300 – 28.6% S150 – 12.8% PL – 0.8% P<0.0001	Secukinumab 300 mg dose is superior to the secukinumab 150 mg dose Both were superior to placebo
	AEs:
	Any AEs, incidence rate per 100 subject-years: 245 in S300, 269 in S150, and 323 in PL
	SAE incidence low, comparable among all groups:
	Increased incidence of mild to moderate infections/infestations in secukinumab groups. Only dose related in candida infections
	Serious infections per 100 patient-years: 1 for S300, 0.7 for S150, and 1.5 for PL
	4 MACE events: 2 CVAs and 2 MIs in the secukinumab groups
	Malignancy incidence per 100 subject-years: 0.3 for S300, 2 for S150, and 1.5 for PL
	11 candida infections (oral, genital, mild to moderate): S300: 7, S150: 3, PL: 1
	Grades 1 and 2 neutropenia. 1 subject with Grade 3 neutropenia which first occurred while on PL
	No deaths
	Two of 703 developed ADA, none were neutralizing
ERASURE (2011–2013) subanalysis, Ohtsuki et al,^Citation38 Japanese population, 52 weeks, N=87	Arms: S300 vs S150 vs PL Injections at weeks 1, 2, 3, 4 then monthly until week 48 MC, DB, PG, PC, R	S300 – 82.8% S150 – 86.2% PL – 6.9% P<0.0001 for both doses	S300 – 62.1% S150 – 55.2% PL – 0% P<0.0001 for both doses	S300 – 27.6% S150 – 10.3% PL – 0% P<0.01 for 300 mg dose	Maximum reduction in PASI was seen at week 16 Efficacy of secukinumab was sustained to week 52 Over time, secukinumab 300 mg showed superior efficacy over 150 mg dose especially with higher thresholds PASI 90/100
	AE:
	Patients with AE (number of patients/number of arm) induction: 14/29 in S300, 16/29 in S150, and 12/29 in PL
	Patients with AE, maintenance, per 100 patient-years: 199.7 for S300, 290.7 for S150, 223.1 for PL
	SAEs: pulmonary edema and heart failure (S150), DM2 (S150), pneumonia (S300), and aortic thrombosis/aneurysm (S150)
	No deaths
	No ADAs in the Japanese population
JUNCTURE (2012–2013), Paul et al,^Citation23 12 weeks, N=182	Self-injection with autoinjector/pen: S300 vs S150 vs PL MC, DB, PG, R	S300 – 86.7% S150 – 71.7% PL – 3.3%P<0.0001	S300 – 55% S150 – 40% PL – 0% P<0.0001	S300 – 26.7% S150 – 16.7% PL – 0% P<0.0006	The autoinjector makes it easy for patients to safely and confidently self inject. The autoinjector needle is hidden and is activated by simply placing the cap against the skin
	AE:
	Any AE, number of patients/number of arm: 42/60 in S300, 39/61 in S150, and 33/61 in PL
	SAE: 1 in S300, 2 in S150, and 1 in PL
	A case of serious pneumonia and malignant melanoma in situ reported unrelated to study drug
	No MACE
	1 vulvovaginal and 1 oral candidiasis, mild infections
	Neutropenia in 5% of S300, 8.2% of S150, and 3.3% in PL, Grade 1 or 2
	No deaths
	No ADA antibodies
SCULPTURE (2011–2013), Mrowietz et al,^Citation20 52 weeks, N=966, multicenter, double-blinded parallel group	S300 and S150 Fixed regimen (every 4 weeks, FR) vs retreat as needed (RN) (received treatment to week 12 followed by PL until loss of 20% of maximum PASI score or loss of PASI 75 response) MC, DB, PG, R	PASI 75 at week 12: S300–90.1% S150–84.4% Maintenance of PASI 75 at Week 40/52: S300 RN – 67.7%; S150 RN – 52.4% S300 FR – 78.2%; S150 FR – 62.1% Mantel–Haenszel risk difference with 98.75 confidence used to determine noninferiority analysis			Regular 4 weeks dosing of secukinumab or the fixed regimen is more efficacious for maintenance therapy
	AE rates were similar between all treatment arms (no placebo arm in this trial)
	Most common AEs: nasopharygnitis, headache, URI
	SAE rates were similar in induction phase
	SAE rates in maintenance phase: 14 S300 RN, 18 S300 FR, 13 S150 RN, 12 S150 FR
	Two MACE events – acute MI and fatal cerebral hemorrhagic stroke (study investigator: unrelated)
	One death due to CVA
	Six total neoplasms
	13 candida infections, all mild to moderate oral or genital candidiasis
	Grade 3 neutropenia in 7 patients, transient no serious infections association
	About four of 966 patients had ADAs. Two were neutralizing but not associated with decreased efficacy or pharmacokinetic abnormalities
FEATURE (2012–2013), Blauvelt et al,^Citation24 12 weeks, N=177, multicenter, double-blinded parallel group	Evaluation of self-injection with prefilled syringes (PFS) S300 vs S150 vs PL PFS MC, DB, PG, PC, R	S300 – 75.9% S150 – 69.5% PL – 0% P<0.0001%	S300 – 60.3% S150 – 52.5% PL – 0% P<0.0001	S300 – 43.1% (P<0.0001) S150 – 8.5% (P<0.057) PL – 0%	Good tolerability of self-injections with PFS. The PFS has a spring that reveals then needle once the injector is pressed down
	AEs:
	Any AE, similar among groups (number of patients/number of arm): 30/59 in S300, 34/59 in S150, and 28/59 in PL
	SAEs: 3 in S300, 0 in S150, and 1 in PL, sciatica and exfoliative dermatitis + 2 MACE
	Severe infections: 3 cases, 1:1:1 in S300, S150, and PL
	Two MACE events: CVA and MI in patients with multiple cardiac risk factors prior to starting the study
	No deaths
	Three cases of mild to moderate vulvovaginal candidiasis in S300 and S150
	Grade 1 neutropenia in 5%–9% of patients, 1 patient with Grade 2 neutropenia. None of these patients had serious infections
CLEAR (2014), Thaci et al,^Citation25 52 weeks, N=676	S300 mg vs ustekinumab (dosing per protocol) MC, DB, PG, PC, R	Week 12: S300 – 91 Ustekinumab – 79.1 P=0.0003 Week 16: S300 – 93.1 Ustekinumab – 82.1 P=0.0001%	Week 12: S300 – 72.8 Ustekinumab – 53.4 P<0.0001% Week 16: S300 – 79 Ustekinumab – 57.6 P<0.0001%	Week 12: S300 – 38.9 Ustekinumab – 25.7 P<0.0001% Week 16: S300 – 44.3 Ustekinumab – 28.4 P<0.0001%	Secukinumab is superior to ustekinumab in efficacy and comparable in safety
	AEs:
	Any AE, similar between S300 (62%) vs ustekinumab (58%) (no placebo arm)
	Mild to moderate infections were most common 29% S300 and 25% ustekinumab.
	SAEs 10 in S300 and 10 in ustekinumab groups
	Three MACE: 1 unstable angina, 1 MI, and 1 embolic stroke (dosing groups/drug not listed)
	One malignancy: lung adenocarcinoma
	One injection site reaction – nausea/vomiting
	Two hepatic: transaminitis while on INH
	Three serious infections: appendicitis, diverticulitis, and scrotal abscess
	No deaths
	Candida infections: twelve cases mild, oral, or genital mucocutaneous infections, localized
	Ten cases of oral herpes
	No neutropenia, IBD, or tuberculosis

Abbreviations: MC, multicenter; R, randomized; DB, double-blinded; PG, parallel grouped; PC, placebo-controlled; AE, adverse events; PL, placebo; SAE, serious adverse events; MACE, major adverse cardiac events; CVA, cerebrovascular accident; MI, myocardial infarction; INH, isoniazid; IBD, inflammatory bowel disease; ADAs, antidrug antibodies; URI, upper respiratory tract infection; wk, week; PASI, Psoriasis Area and Severity Index.

Based on the dose-ranging, regimen-finding studies and the Phase III trials, the recommended dosing of secukinumab is 300 mg subcutaneous injections (two 150 mg injections) given at weeks 0, 1, 2, 3, and 4 followed by monthly maintenance dosing. A Phase II trial established the ability of secukinumab to achieve PASI 75 at week 12 in 57% of patients receiving 75 mg and 82% of patient receiving150 mg compared to 9% of patients in the placebo group (P<0.0001 and P<0.0002, respectively).¹⁸ The 150 mg dose was most efficacious if loaded with weekly dosing for the first month followed by monthly maintenance dosing.^18,19 The Phase III trials that followed tested loading doses of 150 and 300 mg for the first month and established that maintenance of PASI with fixed monthly maintenance dosing was greater than retreating patients upon clinical relapse in the Sculpture trial.²⁰

Generally, patients who weigh <90 kg had better PASI 75 response rates than those weighing >90 kg.²¹ The 300 mg dose was rapidly acting and had the highest efficacy, especially in achieving PASI 90/100 among all subgroups including in those over 90 kg, with the greatest maintenance in PASI 75 over time. A recent meta-analysis reviewing clinical trial data found that the 300 mg dose of secukinumab had greater efficacy than the 150 mg dose for both PASI 75 and PASI 90 at week 12, although both were more efficacious than placebo.²² Post hoc subgroup analyses suggest that patients with lower body weight and less severe disease may achieve a reasonable response with the 150 mg dose.¹⁶ A pen and a prefilled syringe are available, both of which are efficacious and easy to use for self-administration in the JUNCTURE²³ and FEATURE trials.²⁴ A lyophilisate powder requiring reconstitution with sterile water (done by health care professionals) is also available as an injection.

To compare the efficacy of secukinumab with available biologics etanercept and ustekinumab, two Phase III comparator studies were completed.^24,25 The FIXTURE trial was a 52-week trial that randomly assigned patients to receive either secukinumab 300 mg, 150 mg, placebo, or etanercept per standard dosing with the ability of nonresponders in the placebo group to get rerandomized to the secukinumab dosing groups at week 12.²⁶ This study illustrated the superiority of secukinumab (77.1% in the 300 mg and 67% in 150 mg dosing group) to placebo (4.9%) and etanercept (44%) in PASI 75 at week 12 as well as the maintenance of PASI 75 from week 12 to week 52 (P<0.0001 for all doses and comparator arm etanercept).²⁶ In this study, a higher rate of PASI 90 and 100 was observed with secukinumab 300 mg (54.2%*+, 24.1%*) and secukinumab 150 mg (41.9%*+, 14.4%*) compared to etanercept (20.7%, 4.3%) and placebo (1.5%, 0%) at week 12 (*P<0.001 for comparison with etanercept, +P<0.001 for comparison with placebo; no PASI 100 responses were observed in the placebo group for comparison).²⁶

The CLEAR trial was a 1-year head-to-head study with 676 subjects who received 300 mg secukinumab or ustekinumab per standard dosing with the primary end point being PASI 90 at week 16.²⁵ Previous studies had illustrated a peak PASI at week 16 with PASI 90 being higher with secukinumab^25,26 compared to PASI 90 responses in Phase III studies for etanercept,^27,28 adalimumab,^29,30 and ustekinumab,^18,31 though these were not head-to-head comparisons. In the CLEAR trial, 79% of patients in the secukinumab 300 mg group achieved PASI 90 compared to 57.6% of patients in the ustekinumab group at week 16 (P<0.0001). A secondary outcome of this study was PASI 75 at 4 weeks, which was 50% in the secukinumab 300 mg group compared to 20.6% in the ustekinumab group (P<0.0001).

Safety

For patients with moderate-to-severe psoriasis, secukinumab is generally well-tolerated (Table 1). The most common adverse events of secukinumab, occurring in more than 1% of patients from pooled analysis of four clinical trials in the first 12 weeks, were nasopharyngitis/upper respiratory tract infections, diarrhea, rhinitis, oral herpes, pharyngitis, and urticaria. The incidence of nasopharyngitis, diarrhea, and upper respiratory infections were similar between the 300 mg and 150 mg secukinumab groups and the etanercept groups with a higher incidence than in placebo groups in the initial 12 weeks. These data when exposure adjusted show an incidence lower or comparable to placebo and etanercept over 52 weeks. There is a boxed warning for infections with the use of secukinumab.¹⁶

IL-17 plays an important role in mucocutaneous immunity; impaired IL-17 immunity has been associated with Candida infections.³² This association is seen with chronic mucocutaneous disease in humans that results in the persistence or recurrence of Candida infections with genetic mutations of IL-17-related genes.³³ IL-17 is also relevant to neutrophil recruitment, thus its blockade may cause neutropenia.^34,35 Given these theoretical concerns, adverse events including candidal infections and neutropenia were of special interest. All Candida infections that occurred in the secukinumab study groups were localized, usually to oral or genital candidiasis with severity rated as mild to moderate.^23–26 These infections were dose dependent among the 300 mg and 150 mg secukinumab groups. One case of severe gastrointestinal candidiasis was reported in the FIXTURE trial; however, it occurred in the etanercept group.²⁴ No cases of chronic mucocutaneous candidiasis were reported in data that was available.

There were 132 patients with either history of tuberculosis or latent tuberculosis enrolled in Phase III trials. There were no cases of reactivation reported; however, a boxed warning recommends screening patients for tuberculosis prior to starting treatment.¹⁶ There are no published recommendations on when to initiate secukinumab therapy in patients who are found to have latent tuberculosis and who are started on prophylactic therapy. The rates of malignancy were reported to be similar between secukinumab and placebo, with exposure-adjusted indices illustrating a higher rate of malignancies in the placebo group. Caution is advised in patients with hypersensitivity reactions, both the auto-injector pen and prefilled syringe have removable latex caps that should be avoided in those with a latex allergy.¹⁶ The incidence of antidrug antibodies was <1%, with very few being neutralizing antibodies. None of these antibodies were associated with loss of clinical efficacy.^23–26

A final boxed warning regarding the use of secukinumab is in patients with inflammatory bowel disease (IBD). A small (N=59), double-blinded, randomized, multicentere study in Europe was terminated early due to therapeutic inefficacy of intravenous secukinumab in patients with severe Crohn’s disease when compared to placebo.³⁶ Additionally, more adverse events were reported for patients in the study receiving secukinumab, including reports of worsening Crohn’s flares and infection.³⁶ Among the study population in secukinumab Phase III trials, three cases of Crohn’s were reported, two flares in patients with existing Crohn’s disease, and one new diagnosis of Crohn’s disease in a patient with signs and symptoms prior to starting the study trial. There were also two ulcerative colitis flares reported during trial studies and two new diagnoses of ulcerative colitis.¹⁶ A causal relationship between secukinumab and IBD has not been established.

There were a total of six major adverse cardiac events (MACE) in the secukinumab 300 mg group, five MACE events in the secukinumab 150 mg group, 1 MACE event in the placebo and etanercept group in the data available from the FDA.^20,24–26 These patients all had cardiovascular risk factors, and these events were deemed unsuspected/unrelated to secukinumab by study investigators. There were seven total deaths reported due to various causes: alcohol intoxication, cerebrovascular accident, intestinal ischemia/hyperkalemia and renal failure, disseminated aspergillosis after liver transplant, myocardial infarction, suicide, and an unknown cause of death in a patient with alcoholic liver disease who died ~3 months after having been discontinued from the study and receiving his last secukinumab injection.^20,24–26 None of these deaths were thought to be related to the study medication.

QOL measures

QOL measures were also evaluated in Phase III clinical trials for secukinumab. The Dermatology Life Quality Index (DLQI) was used to assess impact on QOL, with higher scores signifying greater negative impact on health-related QOL.³⁷ The ERASURE trial showed an improvement in DLQI to 0 or 1 as early as week 4 in 46% of patients in the secukinumab 300 mg group compared to 25% in the secukinumab 150 mg group and 13.8% in placebo group (P<0.01).³⁸ Similarly, the FIXTURE trial showed a statistically significant decrease in DLQI by week 12 in a higher proportion of secukinumab patients compared to etanercept and placebo groups (P<0.001).²⁶ The CLEAR trial demonstrated an improved DLQI in a greater proportion of patients at all time points up to week 16 in the secukinumab 300 mg group compared to the ustekinumab group.²⁵ In addition, the CLEAR trial also used a subjective symptom assessment to evaluate pain, itching, and scaling on an eleven-point scale with a higher score signifying worsening symptoms. The secukinumab group achieved lower scores in pain, itching, and scaling when compared to the ustekinumab group.²⁵

Conclusion and place in therapy

Based on clinical trial data, secukinumab is currently the most efficacious biologic available for the treatment of moderate-to-severe psoriasis with a comparable safety profile to existing biologics. Head-to-head studies illustrated the superiority of secukinumab 300 mg to both etanercept and ustekinumab. Although no head-to-head trial exists comparing the efficacy of adalimumab to secukinumab, a network meta-analysis of randomized controlled data comparing multiple biologics estimates the PASI 75 response rate for adalimumab 40 mg standard dosing protocol to be ~66%, and comparable to the ustekinumab 45 mg dose.³⁹ Given the clinical efficacy data presented in this article and the superiority of secukinumab to ustekinumab in the CLEAR trial, it is reasonable to expect that secukinumab is clinically more effective than adalimumab.

Overall, the safety of secukinumab is comparable to other available biologics. Additionally, the analysis of Phase II data has shown very similar safety data among the IL-17 inhibitors secukinumab, brodalumab, and ixekizumab.⁴⁰ The pooled data from the secukinumab trials is close to 4,000 patients. The safety data available will increase with the completion and publications of the Phase III trial data for the other IL-17 inhibitors, brodalumab and ixekizumab. The increased rate of nonserious infections such as nasopharyngitis and upper respiratory infections is also observed with TNF-α blockers. Certain specific safety concerns with the use of secukinumab include possible worsening of IBD such as Crohn’s disease, neutropenia, and the occurrence of mild to moderate oral or genital candidiasis.

As more biologics become available, the challenge to practitioners will be how to tailor selection of biologic therapy for patients. Considering certain factors may be helpful in therapeutic decision-making: the presence of psoriatic arthritis, IBD, likelihood of patient adherence, and patient preference regarding more frequent injections, body weight, the formation of antidrug antibodies, or therapeutic failure to a previous biologic.⁴¹ In patients with psoriatic arthritis or ankylosing spondylitis, secukinumab is an effective treatment choice with recent approval of both indications by the FDA.^42,43 In patients with IBD, a TNF-α inhibitor such as infliximab and adalimumab is preferred to secukinumab, since these medications provide therapeutic effect and do not carry the risk of potentially worsening IBD. Postmarketing analysis and safety data on other IL-17 inhibitors may be helpful in elucidating the risk of IL-17 inhibition in patients with IBD further.

Considering patient adherence, secukinumab achieves a higher rate of PASI 90 and PASI 100 compared to other available biologics. Thus, secukinumab may be less likely to require combination therapy. Patient preference regarding the frequency of medication administration should also be considered. Initially, the dosing of secukinumab is more frequent during the induction phase with five weekly injections with two syringes followed by monthly injections with two syringes (150 mg each). About 150 mg (one syringe) of secukinumab may be considered for use in patients with less severe disease and in those <90 kg, though this dose is unlikely to be superior to adalimumab or ustekinumab. The 150 mg dose of secukinumab in a meta-analysis evaluating long-term treatment options showed a small significant difference (relative risk [RR] 0.80 with 95% confidence interval [CI] 0.72, 0.89) relative to etanercept 50 mg dosing per protocol (RR 0.67 with 95% CI 0.57, 0.79).⁴⁴ Compared to other available biologics, the maintenance dosing of the secukinumab is less frequent than both etanercept and adalimumab, but more frequent than ustekinumab.

Providers could consider using secukinumab if patients have failed TNF-α agents, because secukinumab targets an alternative immune pathway. The use of secukinumab in the ustekinumab nonresponders is less clear, because its mechanism is more proximal and related to the IL-17 pathway. There are no published studies evaluating the efficacy of secukinumab in patients who have failed prior biologics. In patients who have formed antidrug antibodies to other biologics, treatment with secukinumab could be considered. Secukinumab has a low rate of antidrug antibody formation, none of which were associated with loss of clinical efficacy in clinical trials.^{20,24–26,45}

Moderate-to-severe psoriasis has a tremendous negative impact on QOL and work productivity, especially when associated with comorbidities, such as psoriatic arthritis.⁴⁶ Still, undertreatment and dissatisfaction with treatment remain high among patients either due to inefficacy, cost, or difficulty with access.⁴⁷ Finally, the identification of new immune pathways involved in psoriasis and the advent of new biologics such as secukinumab allow providers to achieve higher clearance rates for patients than ever before. Secukinumab specifically achieves quick clearance (PASI 50/75) within 4 weeks and maintenance of PASI 75 in ~70%–80% of patients, PASI 90 in ~50%–60%, and PASI 100 in 20%–40% of patients based on clinical studies (Table 1).^23–26 Postmarketing data and further studies using secukinumab in combination therapy, in patients who have failed other biologics, and in patients with TNF-α-induced psoriasis are of great interest.

Disclosure

The authors report no conflicts of interest in this work.