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Original Research

A multicomponent frailty intervention for socioeconomically vulnerable older adults: a designed-delay study

, , , , , , , & show all
Pages 1799-1814 | Published online: 19 Sep 2018

Abstract

Purpose

The primary aim of this study was to evaluate the effectiveness of a 6-month multicomponent intervention on physical function in socioeconomically vulnerable older adults in rural communities. As secondary aims, we evaluated the effectiveness of the intervention on frailty and other geriatric syndromes, sustained benefit at 12 months, and baseline characteristics associated with poor response.

Patients and methods

This designed-delay study was conducted in 187 adults (mean age: 77 years; 75% women) who were living alone or on a low income in three rural regions of Korea. A 24-week multicomponent program that consisted of group exercise, nutritional supplementation, depression management, deprescribing medications, and home hazard reduction was implemented with a planned 6-month interval from August 2015 through January 2017. The primary outcome was physical function, measured using the Short Physical Performance Battery (SPPB) score (range: 0–12; minimum clinically important difference ≥1) at 6 months. Secondary outcomes included frailty phenotype, sarcopenia, Mini Nutritional Assessment-Short Form score (range: 0–14), Center for Epidemiologic Studies-Depression Scale score (range: 0–60), and falls.

Results

At 6 months, the SPPB score increased by 3.18 points (95% CI: 2.89, 3.48) from baseline. The program improved frailty (odds ratio: 0.06; 95% CI: 0.02, 0.16), sarcopenia (odds ratio: 0.32; 95% CI: 0.15, 0.68), Mini Nutritional Assessment-Short Form score by 1.67 points (95% CI: 1.28, 2.06), and Center for Epidemiologic Studies-Depression Scale score by −3.83 points (95% CI: −5.26, −2.39), except for fall (rate ratio: 0.99; 95% CI: 0.69, 1.43). These beneficial effects were sustained at 12 months. Body mass index ≥27 kg/m2 and instrumental activities of daily living disability at baseline were associated with poor improvement in the SPPB score.

Conclusion

This 24-week multicomponent program had sustained beneficial effects up to 1 year on physical function, frailty, sarcopenia, depressive symptoms, and nutritional status in socioeconomically vulnerable older adults in rural communities. (ClinicalTrials.gov, NCT 02554994)

Introduction

The prevalence of frailty is disproportionately high in older adults who have limited social support or who live in rural areas.Citation1,Citation2 Due to limited access to health care facilities and resources in rural area, these older adults may be at greater risk for functional decline. A community-based public health intervention may be needed to reduce the risk of frailty and its consequences.

Several randomized controlled trials have tested the effect of interventions targeting major risk factors for functional decline, such as physical inactivity, nutritional status, depression, or falls, in older adults. Some studies showed that exercise and nutritional supplementation improved physical function and frailty,Citation3Citation6 whereas others found limited benefits.Citation7Citation9 This heterogeneity is possibly due to differences in the intervention (exercise alone vs multicomponent, individual vs group, or center-based intervention vs home-based intervention), adherence, loss to follow-up, or target populations. In particular, the effectiveness and feasibility of these interventions in a resource-limited rural setting have not been well studied. Because designing a public health intervention with sustained benefit is a high priority for rural communities, it is useful to learn how long the benefit can be maintained once the intervention is completed. In addition, identifying the characteristics of people who are unlikely to improve from this intervention is important as they may need personalized case management, instead of a group intervention.

In this paper, we report the results of a designed-delay intervention study to evaluate the effectiveness of a 6-month multicomponent program that comprises group exercise training, nutritional supplementation, depression management, deprescribing medications, and home hazard reduction in older adults who live alone or are on low income in rural communities in Korea. The primary aim was to test the hypothesis that our multicomponent program would improve physical performance in 6 months. As secondary aims, we evaluated the effectiveness of the intervention on frailty and other geriatric syndromes, sustained benefit at 12 months, and baseline characteristics associated with poor response to our program.

Patients and methods

Study design

We conducted a designed-delay study wherein the intervention was rolled out sequentially in three geographic regions with a planned 6-month interval (see ). This pragmatic design was chosen after consulting regional and local public health workers and town representatives, who expressed concerns about the limited resources at the public health centers to conduct a randomized controlled trial and unfamiliarity of public health workers and town residents with random treatment assignment. A designed-delay study allowed efficient use of the existing infrastructure and limited resources by implementing the program in one region at a time, while residents in all three regions received the intervention after a prespecified delay during the study period. The effectiveness of an intervention can be evaluated by comparing the outcome with a historical (pre-intervention period) comparison group as well as a concurrent (non-intervention region) comparison group. Based on these results from the three regions, the public health center can decide whether or not to adopt this intervention for the entire county. The study protocol was approved by the Institutional Review Board of the Asan Medical Center (Research Protocol 2015-0706) and was registered with ClinicalTrials.gov (NCT 02554994).

Figure 1 Study design and population of the Aging Study of Pyeongchang Rural Area, an intervention study.

Notes: Participants for this study were selected from the Aging Study of Pyeongchang Rural Area, a population-based, prospective cohort study of aging in 1,267 adults aged 65 years or older who live in three regions of Pyeongchang County, Gangwon Province, Korea. The 24-week intervention was delivered in one geographic region at a time. Enrolled individuals in region A participated in the multicomponent intervention program from August 2015 through January 2016; those in region B did so from February 2016 through July 2016; and those in region C participated from August 2016 through January 2017. All participants were assessed every 6 months for physical function.
Abbreviation: ASPRA, Aging Study of Pyeongchang Rural Area.
Figure 1 Study design and population of the Aging Study of Pyeongchang Rural Area, an intervention study.

Study population

This study was conducted between August 2015 and January 2017 in Pyeongchang County, a rural area located 180 km east of Seoul. The study population was recruited from the Aging Study of Pyeongchang Rural Area (ASPRA), a population-based, prospective cohort study of 1,267 adults aged ≥65 years who lived in Pyeongchang County.Citation10 The cohort included over 90% of older adults living in the study area. Individuals were included if they 1) were currently living in the three regions; 2) were aged 65 years or older; 3) were living alone or receiving medical aid services; and 4) signed informed consent. The exclusion criteria were as follows: 1) unable to walk 100 m; 2) institutionalized in the past 6 months; 3) diagnosed with end-stage heart failure, end-stage renal disease, or metastatic cancer; 4) cognitively impaired (Mini-Mental State Examination score ≤18); and 5) planning to move out of the study area in the next 6 months. All participants provided written informed consent.

A multicomponent program

A 24-week multicomponent program was implemented in one geographic region at a time: region A in August 2015–January 2016, region B in February 2016–July 2016, and region C in August 2016–January 2017. During the pre-intervention period, participants received usual care from the local public health centers. Usual care consists of ambulatory visit every month or as needed for medical management of chronic conditions from local public health centers without receiving any component of the intervention (described later). During the intervention period, they received group exercise training, nutritional supplements, depression management, deprescription of medications, and home hazard reduction (). Our intervention team comprised two part-time exercise trainers (equivalent to 15% of weekly working hours), three part-time physicians (5% of weekly working hours), and two nurses or social workers (30% of weekly working hours). A 60-minute group exercise session was held twice weekly by licensed exercise trainers at a local town hall. Each session focused on resistance, balance, and aerobic capacity for ~20 minutes each. Participants were given a written guide for exercises and were encouraged to exercise for 60 minutes daily on their own. In addition, all participants received two 125 mL nutritional supplement packs (ready to drink) per day. The nutritional supplement was provided free of charge by Maeil Dairies Co., Ltd (Seoul, Korea). Individuals with high depressive symptoms were evaluated monthly by a geriatrician or a psychiatrist and received pharmacologic management or supportive psychotherapy as indicated. Individuals taking ≥5 prescription drugs were evaluated monthly by a geriatrician for the discontinuation or reduction of potentially inappropriate medications according to the 2012 Beers criteria.Citation11 Visiting nurses and social workers made home visits to identify and fix anything that could lead to home hazards using the Home Fall Prevention Checklist by Centers for Disease Control and Prevention.Citation12

Table 1 Description of multicomponent intervention program

Outcome assessment

Our primary outcome was change in physical function over 6 months, measured using the Short Physical Performance Battery (SPPB) that comprised repeated chair stands, standing balance, and gait speed.Citation13 The minimal clinically important change in SPPB was a change of 1 point.Citation14 Secondary outcomes were 1) frailty phenotype,Citation15 2) sarcopenia,Citation16,Citation17 3) nutritional risk,Citation18 4) depressive mood,Citation19 5) number of falls, and 6) number of emergency room visits and hospitalizations (see Table S1). Assessments of SPPB, frailty, sarcopenia, nutritional risk, and depressive symptoms were performed every 6 months by a team of seven to eight trained nurses who were not aware of the participation status in the intervention study. Self-reported falls and health care utilization were assessed on a monthly basis during the intervention period to ensure the safety of participants; they were assessed every 3 months during the non-intervention period.Citation20

Other measurements

Trained nurses collected sociodemographic information and assessed multimorbidity, polypharmacy, activities of daily living (ADL), and instrumental activities of daily living (IADL), as shown in Table S1. During the intervention period, we calculated the attendance to the group exercise sessions and the number of nutritional supplements consumed on a weekly basis; in addition, we assessed the attendance to monthly evaluation and management for depression and polypharmacy in those who were eligible for the respective intervention at the beginning of the intervention (baseline). The adherence rate was calculated by the number of sessions attended divided by the total number of sessions for each intervention component (or the number of nutritional supplement packs consumed divided by the total packs distributed) during the intervention period. A standardized questionnaire was used to assess severe adverse events requiring emergency room visit or hospitalization.

Statistical analysis

We estimated that at least 78 participants would be needed to detect a 1-point change in the SPPB score over 6 months, assuming the SD of the change score to be 2.1 points and 10% loss to follow-up.Citation4,Citation14 There were no planned interim analyses or stopping rules. Using two-sample t-test and chi-squared test, we examined how the characteristics of participants in the intervention study differed from those who declined to participate.

To assess the effectiveness of our multicomponent intervention program, we assessed the change in the mean SPPB score before and after the intervention for each geographic region. For continuous outcome measures, including SPPB, Center for Epidemiologic Studies Depression Scale (CES-D), and Mini Nutritional Assessment-Short Form scores, we used linear mixed-effects models that included a random intercept term for each participant and fixed-effect terms for time indicators (using the beginning of the intervention as baseline) and indicators for geographic regions. We used logistic mixed-effects models for frailty and sarcopenia with the same random- and fixed-effect terms and negative binomial mixed-effects model for the number of falls with log follow-up time as an offset. From these models, we estimated the program’s immediate and sustained effects on the outcomes and its 95% CIs. As a post hoc secondary analysis, we included time indicators-by-subgroup interaction terms in the mixed-effects model to evaluate effect modification by baseline characteristics. In addition, we applied random forestsCitation21 to identify baseline characteristics that predict good responders to the program. Good response was defined as an increase in the SPPB score >1 point or the total SPPB score >10 (out of 12 points) by the end of the intervention. Important baseline variables were selected by inspecting the mean decrease in accuracy due to exclusion of each variable in the “out-of-bag” sample which was not used to develop the decision rule.Citation21 We calculated the proportion of good vs poor responders according to these characteristics. All analyses were performed using R software version 3.3.3,Citation22 and a two-sided P-value <0.05 was considered statistically significant.

Results

Study population

Of the 1,267 ASPRA cohort participants, 393 (31.0%) were eligible (). After excluding 206 who declined the intervention (n=196) or met the exclusion criteria (n=10), we enrolled 187 individuals. Compared with the excluded individuals, the included individuals were older (mean age, 77.4 vs 76.0 years) and had a poorer health status, as evidenced by higher prevalence of multimorbidity (61.0% vs 42.2%), polypharmacy (53.5% vs 22.8%), ADL disability (24.6% vs 16.0%), sarcopenia (49.2% vs 35.9%), undernutrition (78.1% vs 41.3%), and fall history (26.7% vs 14.1%), as shown in Table S2. Although the prevalence of geriatric conditions varied across the three regions, multimorbidity, polypharmacy, sarcopenia, and undernutrition were common (). The mean SPPB score ranged from 7.0 to 7.8 points; 25.8%–43.2% met the frailty phenotype criteria and 33.3%–46.5% had gait speed <0.6 m/s.

Table 2 Characteristics of the participants in Aging Study of Pyeongchang Rural Area, an intervention study

Adherence and follow-up

On average, participants attended 83.7% of the group exercise sessions during the 24-week period and consumed 87.8% of nutrition packs provided during the intervention period (). Those with greater depressive symptoms (n=33) and polypharmacy (n=100) attended 88% of evaluations which were conducted by a geriatrician or a psychiatrist. Home hazards were reduced in 91% of individuals who were identified as having a greater risk for home hazards at baseline. During the intervention period, six serious adverse events were reported: one distal radius fracture, one heart failure exacerbation, one coronary artery revascularization, one peptic ulcer, one metastatic lung cancer, and one fatal hemorrhagic stroke. Seven participants in region B (five refused due to health-related reasons and two moved out of the area) and one participant in region C (refused follow-up due to health-related reasons) were lost to follow-up.

Table 3 Adherence to multicomponent intervention program

Effectiveness of a multicomponent program

The multicomponent program had a sustained positive effect on physical function (). Since we repeated outcome assessment 6 months after the conclusion of intervention in regions A and B, we were able to assess the sustained effectiveness of our intervention at 12 months. The SPPB score did not change before the intervention; however, it increased with the intervention and changed minimally after the intervention. Compared with the baseline score, the SPPB score increased by 3.18 points (95% CI: 2.89, 3.48) at 6 months and by 3.24 points (95% CI: 2.88, 3.60) at 12 months (). The program substantially reduced frailty (odds ratio: 0.08 at 6 months and 0.06 at 12 months) and sarcopenia (odds ratio: 0.21 at 6 months and 0.32 at 12 months). The Mini Nutritional Assessment-Short Form score improved by 1.67 points at 12 months (95% CI: 1.28, 2.06); the CES-D score improved at 6 months (−3.36 points; 95% CI: −4.55, −2.17) and at 12 months (−3.83 points; 95% CI: −5.26, −2.39). However, the rate of falls did not significantly reduce (rate ratio: 0.99 at 6 months and 1.18 at 12 months).

Figure 2 Physical function before and after multicomponent intervention program.

Table 4 Effects of multicomponent program on physical function, frailty, and other geriatric conditions

Notes: The mean (node) and SD (vertical bar) of the SPPB score are presented for participants in the three geographic regions before and after the multicomponent intervention program. The intervention period is denoted in red. The table below the graph presents the mean±SD for each region.
Abbreviation: SPPB, Short Physical Performance Battery.
Figure 2 Physical function before and after multicomponent intervention program. Table 4 Effects of multicomponent program on physical function, frailty, and other geriatric conditionsDownload CSVDisplay Table

Post hoc analysis

Female gender, multimorbidity, gait speed <0.6 m/s, frailty, CES-D score >20 points, and ADL disability at baseline were associated with greater improvements in the SPPB score after the program (P-value for interaction <0.05), as shown in Figure S1. When we examined the baseline variables for predicting >1-point SPPB improvement or >10 points at the end of the intervention, we found body mass index and IADL disability as the two most important baseline characteristics (). Body mass index <27 kg/m2 and the absence of IADL disability at baseline were associated with good response to the intervention; the proportion of good responders decreased from 92% (84 of 91) to 53% (10 of 19) when patients with body mass index ≥27 kg/m2 and IADL disability were considered.

Figure 3 Prediction of response to multicomponent intervention program.

Notes: Good responders were defined as either those having an increase of >1 point in the SPPB score over the 24-week intervention period compared with the baseline score, or those with a total SPPB score increase of >10 points (range: 0–12 points; higher score indicates better physical function) at 6 months. Numbers on the top of the graph represent the number of poor responders/number of participants in each category.
Abbreviations: BMI, body mass index; IADL, instrumental activities of daily living; SPPB, Short Physical Performance Battery.
Figure 3 Prediction of response to multicomponent intervention program.

Discussion

This designed-delay intervention study found that our 24-week intervention program resulted in a clinically meaningful improvement in terms of physical function, frailty, sarcopenia, nutritional risk, and depression symptoms in older adults who were living alone or had low income in the rural community. Except for falls, the benefit was sustained for most outcomes at 6 months after the intervention. As such, a consistent level of improvement across the three different regions and three different periods provides strong evidence for the effectiveness of our intervention. In addition, the design and protocol of our study demonstrate that the effectiveness of a public health program can be evaluated in a resource-limited setting without randomization.

The results of our trial are consistent with the benefit of exercise alone or multicomponent interventions on objective measures of physical function reported in the literature (). Four studies showed a modest improvement in physical functionCitation3,Citation7,Citation8,Citation23 (eg, SPPB score 0.6Citation23–1.0 pointCitation8) with exercise alone. Five studies of multicomponent interventions that included exercise, nutritional supplementation, and other interventions (eg, mental health provider referral,Citation4 cognitive trainingCitation5) showed a moderate improvement in physical functionCitation4,Citation6,Citation24 (eg, SPPB score 1.4Citation4–2.0 pointsCitation6) and frailty phenotype.Citation4Citation6,Citation9 These are possibly due to lower adherence, difference in the intervention (targeting fewer components), nutritional supplementation only in selected individuals, and choice of young and less frail target populations in other studies. The Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT) trial will confirm the long-term benefits of a multicomponent intervention in preventing mobility impairment in 1,500 older adults with frailty and sarcopenia in nine European countries.Citation25

Table 5 Randomized controlled trials of exercise intervention in community-dwelling older adults at risk for functional decline

Our main objective was to evaluate the effectiveness of the intervention within the existing infrastructure of the regional public health center rather than establishing a clinical trial center. Therefore, our study design was influenced by the input from regional and local public health workers and town representatives. We enrolled residents who were living alone or on low income, because they had been identified by the local public health centers as high-priority individuals for various public health interventions. We previously found high burden of frailty and geriatric syndromes in these residents.Citation10 Another advantage of targeting this population was that we were able to achieve efficient enrollment, high adherence, high retention, and more complete outcome assessment.

Although a randomized controlled trial is considered the gold standard to test the efficacy of an intervention, barriers to conducting a randomized controlled trial in rural areas have been well described.Citation26Citation29 Previous research showed that older adults with low educational attainment or in rural communities might be unfamiliar with randomization.Citation26Citation29 Public health officials are more interested in pragmatic implementation and evaluation of a program than scientific rigor; typically, the program evaluation is based on pre- vs post-intervention comparison. Such a design is subject to bias due to concurrent changes in clinical and public health practice that can result in an improvement in the outcome, unrelated to the intervention itself. Since most participants in our study received medical and preventive care through the local public health centers, we are certain that there were no major changes in usual care during the study period. Moreover, stable SPPB score in the pre-intervention period excludes the possibility of a practice effect or a spontaneous improvement. In summary, our study demonstrates that a designed-delay study can be an economically favorable alternative for testing the effectiveness of new therapies, programs, or policy changes in the routine care setting.Citation30,Citation31

This study has several limitations that deserve mention. First, our results derived from socioeconomically vulnerable older Koreans living in rural areas may not be generalizable to other populations. However, we believe that the physiologic effects of our program would be similar across populations. Second, the adherence to individual components of the intervention was less than perfect. We were unable to distinguish the effect of individual components. Our exercise and nutritional interventions were not individualized according to the nutritional status or muscle condition of each individual, mainly for practical reasons. Nonetheless, our intervention was highly effective in improving the physical function, as shown in other multicomponent interventions for geriatric syndromes (eg, fallsCitation32 and deliriumCitation33). Third, in a designed-delay study where the intervention was rolled out sequentially to different regions, any concurrent interventions outside our study may have affected the SPPB score. Given the nature of our intervention (eg, group exercise session, nutritional supplements, physician evaluation, and home safety evaluation) and the distance between the regions of intervention, we think that the chance of contamination across different regions is low. Fourth, we were unable to examine long-term clinical outcomes, such as mortality or institutionalization, because all participants received the intervention at some point. Fifth, in assessing falls and health care utilization, we interviewed participants on a monthly basis during the intervention period for safety monitoring and every 3 months during the non-intervention period. Higher surveillance frequency during the intervention period may have resulted in larger numbers of these outcomes at 6 months, which may have caused underestimation of the beneficial effect. Finally, further validation is needed to confirm whether obesity and IADL disability are predictors of poor response.

Conclusion

Our study shows that a 24-week multicomponent intervention program can effectively improve physical function, frailty, sarcopenia, depressive symptoms, and nutritional status in community-dwelling older populations. Most benefits seem to last at least 6 months after the intervention. A widespread adoption of our program as a public health intervention can potentially promote relatively healthy aging in older people.

Author contributions

All authors participated in designing the study concept, performed statistical analysis, data analysis, and interpretation, and drafted the manuscript. The agreement is to be accountable for all aspects of the work in ensuring that the accuracy or integrity of any part of the work is appropriately investigated and resolved. All authors read and revised this manuscript. This manuscript is the final approval of version from all authors. All authors have reviewed and agreed to be responsible for the process, accuracy, and integrity of all parts of this manuscript.

Acknowledgments

We are indebted to the public health professionals and nurses of the Pyeongchang County Hospital, Public Health Center, and Community Health Posts for their administrative support and efforts in enrollment, retention, and measurements. We are also grateful to the representatives of each town who provided advice on the location, time, and duration of exercise intervention to maximize participant adherence.

The ASPRA, an intervention study, was funded by the Pyeongchang County Hospital, Pyeongchang County, Gangwon Province, Korea. This work was also supported, in part, by the Harvard Catalyst/The Harvard Clinical and Translational Science Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health Award UL1 TR001102) as well as by financial contributions from the Harvard University and its affiliated academic health care centers. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Harvard Catalyst, the Harvard University and its affiliated academic health care centers, or the National Institutes of Health.

Dr Dae Hyun Kim is supported by the Paul B Beeson Clinical Scientist Development Award in Aging (K08AG051187) from the National Institute on Aging, American Federation for Aging Research, The John A Hartford Foundation, and The Atlantic Philanthropies. He is also supported by the Boston Claude D Pepper Older Americans Independence Center/Pilot and Exploratory Studies Core Award (P30AG031679) and the Boston Roybal Center Pilot Award (P30AG048785).

The abstract of this paper was presented at the American Geriatrics Society 2018 Annual Scientific Meeting as a poster presentation with interim findings. The poster’s abstract was published in “Abstract Supplement” in Journal of the American Geriatrics Society: Currently available at https://meeting.americangeriatrics.org/sites/default/files/inline-files/2018-Journal_of_the_American_Geriatrics_Society.pdf. Sponsor’s role: Public health professionals and nurses of Pyeo-ngchang County Hospital were involved in data collection, but they did not have any role in the study design, analysis or interpretation of data, writing of the paper, or the decision to submit the paper for publication. Paul Park and Maeil Dairies Co., Ltd did not have any role in the study design, collection, analysis or interpretation of data, writing of the paper, or decision to submit the paper for publication.

Disclosure

Dr Dae Hyun Kim is a consultant to Alosa Health, a nonprofit educational organization with no relationship to any drug or device manufacturer. The other authors declare that there is no potential conflict of interests regarding the publication of this article.

Supplementary materials

Figure S1 Effect of multicomponent program by subgroups defined by baseline characteristics.

Note: Female gender, multimorbidity, gait speed <0.6 m/s, frailty, CES-D score >20 points, and ADL disability at baseline were associated with greater improvements in the SPPB score after the program (P-value for interaction <0.05).

Abbreviations: ADL, activities of daily living; CES-D, Center for Epidemiologic Studies Depression Scale; IADL, instrumental activities of daily living; MNA-SF, Mini Nutritional Assessment-Short Form; SPPB, Short Physical Performance Battery.

Figure S1 Effect of multicomponent program by subgroups defined by baseline characteristics.Note: Female gender, multimorbidity, gait speed <0.6 m/s, frailty, CES-D score >20 points, and ADL disability at baseline were associated with greater improvements in the SPPB score after the program (P-value for interaction <0.05).Abbreviations: ADL, activities of daily living; CES-D, Center for Epidemiologic Studies Depression Scale; IADL, instrumental activities of daily living; MNA-SF, Mini Nutritional Assessment-Short Form; SPPB, Short Physical Performance Battery.
Figure S1 Effect of multicomponent program by subgroups defined by baseline characteristics.Note: Female gender, multimorbidity, gait speed <0.6 m/s, frailty, CES-D score >20 points, and ADL disability at baseline were associated with greater improvements in the SPPB score after the program (P-value for interaction <0.05).Abbreviations: ADL, activities of daily living; CES-D, Center for Epidemiologic Studies Depression Scale; IADL, instrumental activities of daily living; MNA-SF, Mini Nutritional Assessment-Short Form; SPPB, Short Physical Performance Battery.

Table S1 Details of outcome assessments and other measurements

Table S2 Characteristics of individuals who were included or excluded from the Aging Study of Pyeongchang Rural Area, an intervention study

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