Abstract
Background
The primary aim of the present study was to verify the potential risk factors for developing a delirium after hip fracture surgery. The secondary aim of this study was to examine the related clinical outcomes after a delirium developed post-hip fracture surgery.
Patients and methods
Data were extracted from a prospective hip fracture database and completed by retrospective review of the hospital records. A total of 463 patients undergoing hip fracture (hip hemiarthroplasty) surgery in a level II trauma teaching hospital between January 2011 and May 2016 were included. Delirium was measured using the Delirium Observation Screening Scale, the confusion assessment method, and an observatory judgment by geriatric medicine specialists.
Results
The results showed that 26% of the patients (n=121) developed a delirium during hospital stay with a median duration during admission of 5 days (IQR 3–7). The multivariable model showed that the development of delirium was significantly explained by dementia (OR 2.75, P=0.001), age (OR 1.06, P=0.005), and an infection during admission (pneumonia, deep surgical site infection, or urinary tract infection) (OR 1.23, P=0.046). After 1 year of follow-up, patients who developed delirium after hip fracture surgery were significantly more discharged to (semi-independent) nursing homes (P<0.001) and had a significantly higher mortality rate (P<0.001) compared to patients without delirium after hip fracture surgery.
Conclusions
The results showed that 26% of the patients undergoing hip fracture surgery developed a delirium. The risk factors including age, dementia, and infection during admission significantly predicted the development of the delirium. No association was confirmed between delirium and time of admission or time to surgery. The development of delirium after hip fracture surgery was subsequently found to be a significant predictor of admission to a nursing home and mortality after 1 year.
Introduction
Due to the increasing life expectancy, the number of persons aged over 70 years will double within the next three decades.Citation1 Especially, this increasing elderly population is at risk of hip fractures.Citation2 Following a hip fracture, even frail patients with major comorbidities are in need for surgery, aiming for pain relief and early mobilization.Citation3,Citation4 In the frail population of hip fracture patients, complications after surgery are inevitable and high incidence rates of pneumonia (5.9%), surgical site infections (5%), and myocardial infarction (1.9%) have been reported.Citation3,Citation5 The most frequent complication during admission after hip fracture surgery is delirium with incidence rates ranging between 23% and 39%.Citation6–Citation8 Postoperative delirium is subsequently associated with higher rates of impaired functional and cognitive recovery, and a prolonged hospital stay with higher mortality rates and treatment costs.Citation6,Citation7,Citation9–Citation12 Reducing the rate of delirium after hip fracture surgery is important, and therefore multiple studies have focused on identifying risk factors for delirium or interventions.Citation13–Citation15 Risk factors that have been found in previous literature were age, cognitive impairment, type of admission (acute or elective), institutionalization, functional impairment, body mass index (BMI), level of albumin, American Society of Anesthesiologists (ASA) classification, general anesthesia, parkinsonism, polypharmacy, and vision impairment.Citation13,Citation16–Citation18 Determination of risk factors for delirium after hip fracture surgery supports clinicians to identify patients at risk and enabling preventive measures. The aim of the present study was therefore to validate earlier suggested risk factors, which helps clinicians to identify high-risk patients for delirium. Moreover, the current study aimed to examine the delirium outcomes as adverse events, length of hospital stay, and mortality rates to gain a more complete insight into the outcomes of delirium after hip fracture surgery.
Patients and methods
Patient selection
This study enrolled patients who underwent surgical treatment for proximal hip fractures at a single-center level II trauma teaching hospital in Rotterdam (the Netherlands) from January 1, 2011 to May 1, 2016. All patients treated with a hemiarthroplasty (HA) were selected for analyses (n=463) (). The baseline characteristics and clinical outcomes were retrospectively obtained from the hospital records using a prospective registry. The study protocol was approved by the local ethics committee (L2017044, TWOR, Rotterdam). Because of the high percentage of cognitive dysfunction and no change in standard practice of care, the local ethics committee decided that patients’ consent to review their medical records was not required. Patient data were stored anonymously and all the protocols were conducted in compliance with the Declaration of Helsinki. Moreover, no external funding was used for this study. All operations were performed by six orthopedic trauma surgeons in a laminar air flow theater, and the standard implant was a cemented unipolar (Palamed G, gentamicin impregnated cement; Heraeus, Hanau, Germany) prosthesis (Mathys CCA; Mathys Ltd. Bettlach, Switzerland). Standard antibiotic prophylaxis prior to surgery included 1–3 g cefazolin (Kefzol). Till January 2016, patients were hospitalized at the orthopedic department during admission. After January 2016, the patients were admitted at a geriatric trauma unit within the orthopedic department.
Figure 1 Flow chart of included patients.
Risk factors for delirium
To evaluate the risk factors for delirium after hip fracture surgery, baseline characteristics of all the included patients, including age, gender, and medication, were collected. Comorbidities were divided into the following categories: rheumatoid arthritis, liver and kidney function, Parkinson’s disease, cardio- or cerebrovascular disease, previous hip fracture surgery, oncological status, and the use of walking aids. Data on nutritional status were collected using the BMI and Short Nutritional Assessment Questionnaire for Residential Care score. Also, information about the living situation (at home or in a nursing home) prior to hospital admission was collected. In this study, patients living in a nursing home were care-dependent due to an extensive degree of either cognitive or physical impairment.
Perioperative risk factors
Since the primary objective of the current study was to examine perioperative risk factors for delirium after hip fracture surgery, we selected perioperative variables described previously in literature as risk factors for the development of delirium after HA.Citation13,Citation16–Citation18 Perioperative factors were time to surgery (hours between admission and surgery), time of operation (surgery during day [hours]), moment of the week (during the week or weekend), estimated blood loss, and reoperations. Duration and type of anesthesia and the ASA score were collected. Furthermore, we used the Nottingham hip fracture score (NHFS) as a frailty prediction score for delirium, which combines the patient’s comorbidities and general status. The NHFS is developed and validated for 30-day mortality rate prediction after hip fracture surgery, including age, sex, number of comorbidities, Mini-Mental Test Score Examination ≤6 out of 10, hemoglobin concentration on admission, residence, and the presence of a malignant disease in the past 20 years.Citation19,Citation20
Delirium
Patients were screened for delirium using the Delirium Observation Screening Scale (DOSS) scored by trained nurses during regular care. Three or more points on the DOSS were considered as highly indicative of delirium. All patients were visited on a daily basis by a physician. If delirium was present or suspected, a geriatrician was consulted and the diagnosis was confirmed based on the DSM-IV criteria.
From 2015 onward, a geriatrician was also consulted prior to surgery as standard care for each patient with a hip fracture.
Adverse events and clinical outcome
The secondary objective of this study was to examine the effect of delirium on a number of complications (medical and surgical adverse events), the length of stay in hospital, mortality (30 days, 3 months, 1 year) and the number of patients newly discharged to a nursing home.
Statistical analysis
Categorical variables are presented as frequencies and percentages. Continuous variables are presented as mean (± SD). The nature of the correlation (eg, linear and quadratic) between candidate predictors and outcome was graphically assessed by locally weighted scatterplot smoothing curves. For a nonlinear correlation, cut-off points were determined based on the observed distribution, clinical grounds, or literature. Associations between potential predictors and the primary outcome delirium were tested by univariable logistic regression. Significant associations observed in univariable analysis and significant variables reported in the literature were included in the multivariable model analyzing the association with delirium.Citation3 Subsequently, backward elimination was performed until all remaining variables reached a P-value <0.10, controlling for the NHFS score.Citation21 The mortality risk after delirium was analyzed with a multivariable model including significant variables reported in literature.Citation12,Citation22 Statistical analyses were performed using Stata version 14.0 (StataCorp, College Station, TX, USA), and all statistical tests were two-sided with a significance level of P<0.05. Mortality rates were estimated and displayed using the Kaplan–Meier estimator ().
Figure 2 Mortality rates in patients with and without delirium during admission (Kaplan–Meier curve).
Results
Baseline characteristics
shows the characteristics, including sub-stratification according to the delirium status, of all 463 patients in the present study. The mean age of the patients was 81±8 years, 67% (n=310) were female, and almost 50% (n=225) of the patients had an ASA score of ≥3. A total of 131 (30%) patients were admitted to a semi-independent or nursing home facility. According to the DOSS and CAM scores, combined with geriatric assessment, 121 patients (26%) had a delirium during hospital stay. The mean age in the delirium group was significantly higher (84 vs 80 years, P<0.001), and more patients in the delirium group (41% vs 16%) had an underlying form of dementia before admission (P<0.001). Significantly more patients were admitted to a semi-independent nursing home (n=53, P=0.003) and nursing home (n=78, P=0.018). Median duration of a delirium during admission was 5 days (IQR 3–7).
Table 1 Baseline characteristics of 463 included patients
Predictors of postoperative delirium
The results of the univariable analysis of the risk and prognostic factors are displayed in . The results suggest the risk of delirium is increased by age (OR 1.07, [95% CI 1.04–1.11], P<0.001), NHFS (OR 1.65, [95% CI 1.38–1.97], P<0.001), ASA score 3 and 4 (OR 1.61, [95% CI 1.05–2.46], P=0.028), previous dementia (OR 3.84, [95% CI 2.40–6.16], P<0.001), glomerular filtration rate (GFR) on admission (OR 0.99, [95% CI 0.98–0.99], P=0.028), semi-independent nursing home (OR 2.53, [95% CI 1.37–4.67], P=0.003) or nursing home (OR 1.92, [95% CI 1.12–3.31], P=0.018), and an infection during admission (pneumonia, deep surgical site infection, or urinary tract infection) (OR 1.91, [95% CI 1.21–3.01], P=0.005). No significant higher risk for delirium was found for gender, BMI, blood loss, type of anesthesia, reoperation rate, time to surgery, and surgery performed around daily working hours.
Table 2 Univariable analyses of risk and prognostic factorsTable Footnotea
Significant associations observed in univariable analysis were included in a multivariable model, correcting for the NHFS (). The multivariable model showed that dementia (OR 2.75, [95% CI 1.51–5.02], P=0.001), age (OR 1.05, [95% CI 1.02–1.09], P=0.005), and an infection during admission (pneumonia, deep surgical site infection, or urinary tract infection) (OR 1.23, [95% CI 1.00–1.50], P=0.046) were significant independent prognostic factors for the development of a delirium, with the largest effect for dementia.
Table 3 Multivariate analyses of risk factors in delirium
Clinical outcome
Clinical outcomes after delirium are shown in . The median length of the primary in-hospital stay in the non-dementia group with a delirium was 11 days, which was not significant compared with 7 days in the non-delirium dementia group (P=0.128). Moreover, patients with a delirium during admission were significantly more often discharged to nursing home (OR 7.06, [95% CI 2.13–23.41], P=0.001) or semi-independent nursing home (OR 11.4, [95% CI 3.4–38.1], P<0.001) facilities. The overall survival rate of the population is shown in (Kaplan–Meier analysis). The 30-day all-cause mortality was 7% (n=33) (delirium-positive 10% vs delirium-negative 6%). After 1 year of follow-up, the all-cause mortality was 24% (n=113) in all patients. In the delirium-positive group, 39% (n=47) died within 1 year after surgery (OR 2.65, [95% CI 1.68–4.18], P<0.001) compared with 19% (n=66) in the non-delirium group. After correction for other confounding factors, delirium remained a significant predictor for 1-year mortality (). A total of 152 patients were followed up at the outpatient clinics for post-discharge control. The other patients were followed up by a nursing home physician at their residence or by a general practitioner at home.
Table 4 Clinical outcomes after delirium
Table 5 Multivariate analyses of risk factors for mortality
Discussion
Surgery in elderly patients has a high impact, especially in the frail population with a hip fracture. Efficient and multidisciplinary perioperative management with early treatment of complications is important to reduce postoperative mortality. The most frequent complication during admission after hip fracture surgery is delirium with incidence rates between 23% and 39%.Citation6–Citation8 In line with previous literature, the incidence rate of delirium in our population was 26% (n=121).Citation6–Citation8,Citation23 The results of the multivariable analysis identified the following independent potential risk factors causing delirium: predisposing dementia, age and an infection during admission (pneumonia, deep surgical site infection, or urinary tract infection). GFR and the NHFS became insignificant factors after multivariate analysis.
Perioperative risk factors
In previous literature, cognitive impairment or dementia is one of the most important risk factors for delirium.Citation16 Voyer et al reported the severity of dementia is a significant indicator for delirium severity, and higher morbidity and mortality rates have been described with delirium superimposed on dementia.Citation24–Citation26 The incidence of delirium in patients with dementia ranges between 57% and 62% during admission in previous literature.Citation9,Citation27 In this study, among patients who underwent hip fracture surgery, 41% (n=49) with dementia developed a delirium during admission, and indeed dementia was a significant factor for developing a delirium. Delirium could thus be a marker of the vulnerable brain with diminished reserve capacity as is present in patient with dementia. Accumulating evidence, however, suggests that delirium itself might lead to permanent cognitive decline and dementia in some patients.Citation28
Age was a significant predictor for delirium, with a median age of 84 years in the delirium group and 80 years in the non-delirium group. This result is in line with reported previous literature among hip fracture patients, including Kalisvaart et al (603 hip surgery patients) and Lee et al (425 hip surgery patients) who found that age was an independent predictive factor for delirium.Citation16,Citation29 During admission, patients with delirium developed significantly more often an infection (pneumonia, urinary tract infection, or wound infection) compared to patients without a delirium (35% vs 22%). Since the diagnosis of an infection was not done in all patients before the occurrence of a delirium, we cannot conclude that an infection is an independent prognostic factor for delirium. However, our study results suggest infections during admission are associated with the occurrence of a delirium during admission.
In accordance with previous literature on hip fracture surgery, our findings showed no significant correlation with time to surgery and the development of a delirium. Moreover, surgery during the weekend or around normal working hours did not show a significant difference. General anesthesia during surgery was performed in 25% of the patients, and there was no difference in delirium prevalence compared to spinal anesthesia as reported earlier.Citation27,Citation30 The correlation between a prolonged length of surgery and delirium has not been previously described, and in accordance we did not find a significant correlation between length of surgery and delirium.Citation27
Clinical outcomes
In line with the literature, the overall survival rate in the delirium-positive group (39%) was significantly lower after 1 year of follow-up than in the non-delirium group (19%), even after correcting for other confounding risk factors as suggested by Dolan et al.Citation12 After correction, also the NHFS and a reoperation after initial surgery remained a significant predictor for 1-year mortality.
The most effective method in delirium care is prevention of its occurrence. Several studies demonstrated that delirium is preventable in one-third of the cases by performing multi-component interventions during admission.Citation28 When high-risk patients are identified earlier, appropriate preventive arrangements can be implemented and most likely will result in a lower delirium rate. As a result, related clinical outcomes as hospital stay and mortality rates may improve significantly. In case of planned, major elective surgery in elderly, early identification of high-risk patients is most effective. Outpatient consultation of a multidisciplinary coordinated team of health care professionals can screen patients on frailty and risk for delirium. Instantly, the modifiable risk factors could be optimized. However, in hip fracture patients, surgery is never planned and by definition semi-acute. The options for preoperative optimization are therefore limited. Still, preoperative cognitive assessment may be one of the most useful methods of identifying those who are at high risk for postoperative delirium and is of major importance to optimize delirium care.
Strengths and limitations
Baseline characteristics and clinical data had to be completed retrospectively, leading to a potential absence of data on confounding factors. Yet, the prospective hip fracture database prevents selection bias and absence of data regarding most variables. Cognitive impairment or dementia was evaluated using medical notes and no distinction was made between the severities of cognitive impairment. In addition, dementia often presents itself during admission, which might result in an underestimation of the number of patients with cognitive disorders in this study.
Conclusion
Our findings showed that, of all potential risk factors suggested in previous literature, only dementia, age, and an infection during admission were significantly associated with an increased risk of delirium after hip fracture surgery. In turn, delirium was found to result in increased admission to nursing homes and a higher risk of mortality after 1 year.
Disclosure
The authors report no conflicts of interest in this work.
References
- LeonDATrends in European life expectancy: A salutary viewInt J Epidemiol201140227127721415000
- KanisJAOdénAMccloskeyEVA systematic review of hip fracture incidence and probability of fracture worldwideOsteoporos Int20122392239225622419370
- JamesonSSKhanSKBakerPA national analysis of complications following hemiarthroplasty for hip fracture in older patientsQJM2012105545546022294648
- NicholsCIVoseJGNunleyRMClinical outcomes and 90-day costs following Hemiarthroplasty or total hip arthroplasty for hip fractureJ Arthroplasty2017329SS128S13428214255
- de JongLKlemTKuijperTMRoukemaGRFactors affecting the rate of surgical site infection in patients after hemiarthroplasty of the hip following a fracture of the neck of the femurBone Joint J201799-B81088109428768787
- KrogsethMWyllerTBEngedalKJuliebøVDelirium is a risk factor for institutionalization and functional decline in older hip fracture patientsJ Psychosom Res2014761687424360144
- GleasonLJSchmittEMKosarCMEffect of delirium and other major complications on outcomes after elective surgery in older adultsJAMA Surg2015150121134114026352694
- YangYZhaoXDongTYangZZhangQZhangYRisk factors for postoperative delirium following hip fracture repair in elderly patients: a systematic review and meta-analysisAging Clin Exp Res2017292115126
- WitloxJEurelingsLSde JongheJFKalisvaartKJEikelenboomPvan GoolWADelirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysisJAMA2010304444345120664045
- KrogsethMWatneLOJuliebøVDelirium is a risk factor for further cognitive decline in cognitively impaired hip fracture patientsArch Gerontol Geriatr201664384426952375
- BellelliGMazzolaPMorandiADuration of postoperative delirium is an independent predictor of 6-month mortality in older adults after hip fractureJ Am Geriatr Soc20146271335134024890941
- DolanMMHawkesWGZimmermanSIDelirium on hospital admission in aged hip fracture patients: prediction of mortality and 2-year functional outcomesJ Gerontol A Biol Sci Med Sci2000559M527M53410995051
- MarcantonioERFlackerJMWrightRJResnickNMReducing delirium after hip fracture: a randomized trialJ Am Geriatr Soc200149551652211380742
- ZhangYShanGJZhangYXPropofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adultsBr J Anaesth2018121359560430115258
- SuXMengZTWuXHDexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trialLancet2016388100541893190227542303
- KalisvaartKJVreeswijkRde JongheJFvan der PloegTvan GoolWAEikelenboomPRisk factors and prediction of postoperative delirium in elderly hip-surgery patients: implementation and validation of a medical risk factor modelJ Am Geriatr Soc200654581782216696749
- OhESLiMFafoworaTMPreoperative risk factors for postoperative delirium following hip fracture repair: a systematic reviewInt J Geriatr Psychiatry201530990091025503071
- ChoiYHKimDHKimTYLimTWKimSWYooJHEarly postoperative delirium after hemiarthroplasty in elderly patients aged over 70 years with displaced femoral neck fractureClin Interv Aging2017121835184229138544
- MaxwellMJMoranCGMoppettIKDevelopment and validation of a preoperative scoring system to predict 30 day mortality in patients undergoing hip fracture surgeryBr J Anaesth2008101451151718723517
- MoppettIKParkerMGriffithsRBowersTWhiteSMMoranCGNottingham hip fracture score: longitudinal and multi-assessmentBr J Anaesth2012109454655022728204
- WhiteIRRoystonPWoodAMMultiple imputation using chained equations: issues and guidance for practiceStat Med201130437739921225900
- KatMGde JongheJFVreeswijkRMortality associated with delirium after hip-surgery: a 2-year follow-up studyAge Ageing201140331231821414946
- FickDMSteisMRWallerJLInouyeSKDelirium superimposed on dementia is associated with prolonged length of stay and poor outcomes in hospitalized older adultsJ Hosp Med20138950050523955965
- VoyerPMccuskerJColeMGSt-JacquesSKhomenkoLFactors associated with delirium severity among older patientsJ Clin Nurs200716581983117462033
- FickDForemanMConsequences of not recognizing delirium superimposed on dementia in hospitalized elderly individualsJ Gerontol Nurs20002613040
- BellelliGFrisoniGBTurcoRLucchiEMagnificoFTrabucchiMDelirium superimposed on dementia predicts 12-month survival in elderly patients discharged from a postacute rehabilitation facilityJ Gerontol A Biol Sci Med Sci200762111306130918000153
- MoskCAMusMVroemenJPDementia and delirium, the outcomes in elderly hip fracture patientsClin Interv Aging20171242143028331300
- InouyeSKWestendorpRGSaczynskiJSDelirium in elderly peopleLancet2014383992091192223992774
- LeeHBMearsSCRosenbergPBLeoutsakosJMGottschalkASieberFEPredisposing factors for postoperative delirium after hip fracture repair in individuals with and without dementiaJ Am Geriatr Soc201159122306231322188077
- IlangoSPulleRCBellJKuysSSGeneral versus spinal anaesthesia and postoperative delirium in an orthogeriatric populationAustralas J Ageing2016351424726364948