77
Views
5
CrossRef citations to date
0
Altmetric
Original Research

Survival after hospital discharge for ST-segment elevation and non-ST-segment elevation acute myocardial infarction: a population-based study

, , , , , & show all
Pages 229-236 | Published online: 22 Jul 2013

Abstract

Background

Limited recent data are available describing differences in long-term survival, and factors affecting prognosis, after ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI), especially from the more generalizable perspective of a population-based investigation. The objectives of this study were to examine differences in post-discharge prognosis after hospitalization for STEMI and NSTEMI, with a particular focus on factors associated with reduced long-term survival.

Methods

We reviewed the medical records of residents of the Worcester, MA, USA metropolitan area hospitalized at eleven central Massachusetts medical centers for acute myocardial infarction (AMI) during 2001, 2003, 2005, and 2007.

Results

A total of 3762 persons were hospitalized with confirmed AMI; of these, 2539 patients (67.5%) were diagnosed with NSTEMI. The average age of study patients was 70.3 years and 42.9% were women. Patients with NSTEMI experienced higher post-discharge death rates with 3-month, 1-year, and 2-year death rates of 12.6%, 23.5%, and 33.2%, respectively, compared to 6.1%, 11.5%, and 16.4% for patients with STEMI. After multivariable adjustment, patients with NSTEMI were significantly more likely to have died after hospital discharge (adjusted hazards ratio 1.28; 95% confidence interval 1.14–1.44). Several demographic (eg, older age) and clinical (eg, history of stroke) factors were associated with reduced long-term survival in patients with NSTEMI and STEMI.

Conclusions

The results of this study in residents of central Massachusetts suggest that patients with NSTEMI are at higher risk for dying after hospital discharge, and several subgroups are at particularly increased risk.

Introduction

Approximately 1 million new and recurrent acute myocardial infarctions (AMI) occur annually in the United States.Citation1 Whereas ST-segment elevation myocardial infarction (STEMI) has long been accepted terminology in the literature and clinical setting,Citation2 the term non-STEMI (NSTEMI) became more commonly used in the mid-1990s.Citation3,Citation4 Classifying patients with AMI into STEMI and NSTEMI has clinical utility since each group is comprised of patients with unique clinical characteristics, different treatment approaches, and in-hospital and short-term survival.Citation5Citation8

Data from randomized trials have shown that hospitalized patients with NSTEMI have a lower risk of dying during the first few weeks after an AMI, but are at higher risk for adverse cardiovascular outcomes over the long-term than patients with a STEMI.Citation9,Citation10 However, data derived from clinical trials may lack generalizability since these study populations generally include younger and healthier individuals than are commonly seen in community-based investigations. Some investigations have reported no differences in 1-year mortality rates between STEMI and NSTEMI patients,Citation6 whereas others have observed higher death rates for patients with STEMI or for those with NSTEMI.Citation7,Citation8 These divergent findings may be explained in part by the different sociodemographic and clinical characteristics of AMI patients being studied as well as to sampling and methodologic approaches utilized to identify the population of interest.

We have previously described the in-hospital and 1-year death rates in patients with NSTEMI and STEMI,Citation11 but more data are needed to delineate the longer-term prognosis of patients with these two major types of AMI, particularly from a more generalizable population-based perspective. Moreover, few recent studies have examined what factors may be associated with post-discharge mortality in these patients and whether these prognostic factors differ between patients with STEMI or NSTEMI.Citation6Citation8

The objectives of this study were to describe relatively contemporary post-hospital discharge all-cause death rates, and factors associated with an increased risk of dying, in patients who were discharged after an AMI from all central Massachusetts hospitals in the 2000s, further classified according to AMI type. Data from the Worcester Heart Attack Study (WHAS), an ongoing, population-based investigation describing the clinical epidemiology of AMI in residents of central Massachusetts, were used in the present investigation.Citation11Citation13

Methods

The WHAS has been collecting data describing the clinical epidemiology of AMI in residents of the Worcester, MA, USA metropolitan area hospitalized at all eleven central Massachusetts medical centers on an approximate alternating yearly basis.Citation11Citation13 For the present study, we included data from only the most recent hospitalized patient cohorts, namely 2001, 2003, 2005, and 2007, in order to describe overall differences, and recent trends, in the epidemiology of STEMI and NSTEMI in this large central New England population. Of the 4208 patients hospitalized during the period under study, 435 died during hospitalization and eleven were lacking information on post-discharge survival. These 446 cases were excluded from the present study. This study was approved by the Committee for the Protection of Human Subjects at the University of Massachusetts Medical School.

Study population

The methodology of the WHAS has been described elsewhere in detail.Citation11Citation13 In brief, the medical records of patients at each central Massachusetts medical center who were hospitalized for possible AMI were reviewed by trained nurses and physicians and were validated according to predetermined criteria.

Patients with STEMI and NSTEMI were classified according to standardized diagnostic criteria that we have used in this study on an ongoing basis.Citation11 A diagnosis of STEMI was made when new ST-segment elevation was present at the J point in two or more contiguous leads. A diagnosis of NSTEMI was accepted when, in the absence of ST-segment elevation, ischemic ST-segment or T wave changes were present for at least 24 hours with positive cardiac enzymes and/or a typical clinical presentation. From 2003 on, in the absence of electrocardiogram (ECG) abnormalities, a diagnosis of NSTEMI was accepted when elevations in various cardiac biomarker assays, including troponin, were accompanied by typical clinical presentation.

Trained nurse and physician study personnel reviewed all baseline and serial ECGs and quality control activities were routinely conducted with respect to ECG interpretation and abstraction of data from hospital medical records. Computer systems at all greater Worcester hospitals also over-read all ECGs and were independently reviewed by trained study personnel. We excluded cases of AMI that developed in the setting of trauma, as a result of a noncardiac condition, in the perioperative period, as well as cases of AMI which occurred in patients who did not reside in the Worcester metropolitan area.

Data collection

Sociodemographic, medical history, laboratory, and clinical data were abstracted from the hospital medical records of eligible patients.Citation11Citation13 Patients were classified as having an initial AMI based on the review of information contained in hospital medical records and the absence of a history of prior coronary disease.Citation12,Citation13 Information on the development of important inpatient clinical complications was also collected based on the review of hospital medical records. These complications included atrial fibrillation, heart failure, cardiogenic shock, and stroke; uniform working definitions of each of these complications were defined in a standardized manner.Citation14Citation17

Post-discharge mortality data were collected through the review of state and Social Security death certificates as well as by reviewing medical records for subsequent readmissions. Our primary study end point was all-cause mortality.

Data analysis

We examined differences in the characteristics of patients discharged from all greater Worcester hospitals with STEMI versus NSTEMI by utilizing t-tests for continuous variables and Chi-square tests for categorical variables. We examined post-discharge survival through 2009, accounting for the varying length of time patients were followed after hospital discharge. A Cox proportional hazards regression approach was utilized to examine the independent association between selected demographic and clinical factors with post-discharge mortality over the period of follow-up. Variables were included in this regression model based on a P-value of ≤0.15 as well as on previously published associations with these factors on long-term prognosis after AMI. Variables associated with high rates of missing data, which occurred for ejection fraction, serum lipids, and body mass index, were not included in our regression models. Post-discharge sociodemographic, clinical, or medical care related variables were not included in our regression models since we did not collect further information about these prognostic factors. Hazard ratios (HRs) and accompanying 95% confidence intervals (CIs) around various point estimates, including overall differences in long-term survival between patients with STEMI and NSTEMI, were calculated in a standardized manner. Using the graphical and numerical methods for model assessment we found that the assumption of proportional hazards was violated by two clinically relevant factors.Citation18 Inasmuch, we conducted a sensitivity analysis using an accelerated failure time model to confirm the validity of the Cox model in light of the presence of nonproportional hazards among these key study covariates – prior medical history of heart failure and systolic blood pressure findings at the time of hospital admission. We added the P-values from this model to . This analysis confirmed that the violation of the proportional hazards assumption did not affect the reliability of our results. A logistic regression analysis was also carried out for purposes of examining differences in post-discharge prognosis at key long-term points (eg, 3 months, 1 year, 2 years) between patients with STEMI versus NSTEMI, with odds ratios (ORs) and accompanying 95% CIs calculated.

Table 2 Factors associated with post-discharge mortality according to type of AMI

Results

Characteristics of study population

A total of 3762 individuals with confirmed AMI were discharged from all metropolitan Worcester hospitals between 2001 and 2007. The average age of study patients was 70.3 years and 42.9% were women. Of these, 2539 patients (67.5%) were diagnosed with NSTEMI.

Patients with NSTEMI were significantly older, included a greater proportion of women, and had more comorbid cardiovascular conditions, but were less likely to have presented with an initial AMI compared to patients with STEMI (). The hospital course of patients with NSTEMI was more likely to have been complicated by the development of atrial fibrillation and heart failure (). Patients with NSTEMI had higher systolic blood pressure and serum glucose levels, and lower estimated glomerular filtration rate (GFR) findings, than patients with STEMI.

Table 1 Characteristics of patients with AMI according to type of AMI

Expectedly, patients with STEMI were more likely to have undergone a percutaneous coronary intervention (PCI), whereas coronary artery bypass graft (CABG) surgery was performed in a similar percentage of both patient groups. Patients with NSTEMI were more likely to have been discharged from the hospital on digoxin and calcium channel blockers, while patients with STEMI were more likely to have been discharged on aspirin, beta-blockers, lipid-lowering agents, and angiotensin-converting-enzyme (ACE)-inhibitors/angiotensin receptor blockers.

Post-hospital discharge prognosis

Patients discharged from greater Worcester hospitals after NSTEMI during the years under study experienced higher post-discharge all-cause death rates with 3-month, 1-year, and 2-year death rates of 12.6%, 23.5%, and 33.2%, respectively, compared with 6.1%, 11.5%, and 16.4% for patients with STEMI (). For our initial two study cohorts (2001 and 2003) in which longer-term follow-up was available, the 5-year death rates were 30.2% and 52.4%, respectively, for patients with STEMI and NSTEMI ().

Figure 1 Post-discharge survival of patients according to type of AMI for patients enrolled in the Worcester Heart Attack Study in 2001, 2003, 2005, and 2007.

Note: Worcester Heart Attack Study data from.Citation11,Citation12,Citation14
Abbreviations: AMI, acute myocardial infarction; NSTEMI, non-ST-segment elevation myocardial infarction; STEMI, ST-segment elevation myocardial infarction.
Figure 1 Post-discharge survival of patients according to type of AMI for patients enrolled in the Worcester Heart Attack Study in 2001, 2003, 2005, and 2007.

After adjusting for baseline differences in age, sex, length of stay, comorbidities, hospital clinical complications, and physiologic variables, patients with STEMI were significantly more likely to have survived at 3 months (OR 1.38; 95% CI 1.01–1.87), 1 year (OR 1.38; 95% CI 1.09–1.74), and 2 years (OR 1.53; 95% CI 1.23–1.89) (all P-values <0.05) after hospital discharge compared to patients with NSTEMI. Overall, patients with NSTEMI were significantly more likely to have died during the years under study than patients with STEMI (adjusted HR = 1.28; 95% CI 1.14–1.44) (P-value <0.05).

Since early coronary revascularization is recommended for patients with STEMI, we carried out an additional subgroup analysis in which we examined differences in post discharge death rates in patients with STEMI and NSTEMI who underwent either PCI or CABG. The results of this crude unadjusted analysis revealed death rates of 3.1% versus 3.2% at 3 months, 6.0% versus 8.4% at 1 year, and 7.9% versus 12.8% at 2 years in patients with STEMI versus NSTEMI, respectively, in patients who underwent coronary revascularization.

Factors associated with post-hospital discharge prognosis

After multivariate adjustment for the sociodemographic characteristics, comorbidities, hospital clinical complications, and admission physiologic variables included in , factors significantly associated with an adverse long-term prognosis following hospital discharge for patients with STEMI included older age, longer hospital stay, previously diagnosed heart failure, diabetes or stroke, development of atrial fibrillation during hospitalization, elevated systolic blood pressure and blood glucose findings at the time of hospital admission, and lower serum estimated GFR findings (). Among patients with NSTEMI, older individuals, men, those with a longer hospital stay, patients with a history of either stroke, heart failure, or diabetes, and those who developed stroke or heart failure during hospitalization were at greater risk for dying than respective comparison groups. Elevated systolic blood pressure and elevated blood glucose levels at the time of hospital presentation as well as lower serum estimated GFR findings were associated with decreased long-term mortality following NSTEMI ().

Discussion

The results of this community-based study demonstrate that the post-discharge death rates for patients hospitalized with NSTEMI were higher than for patients discharged after STEMI. After multivariate adjustment, increasing age was an important predictor of death for both patient groups after hospital discharge, whereas several factors were differentially associated with mortality depending on AMI type.

Similar to the results of other studies,Citation6,Citation7,Citation19 a previous publication from the WHAS showed that patients with NSTEMI were at higher risk for dying during the first year after hospital discharge.Citation11 In the multicenter registry of more than 2100 patients hospitalized with an AMI at 56 centers throughout France,Citation6 patients with NSTEMI experienced higher post-discharge death rates as well as rates of rehospitalization than patients with STEMI. Among a large cohort of patients undergoing cardiac catheterization between 1999 and 2007 at Duke University Medical Center, patients who developed NSTEMI experienced a higher risk of dying over the long-term (median follow-up = 4 years) than patients with STEMI.Citation7 Similarly, when we extended our period of follow-up even further to 5 years after hospital discharge, patients with NSTEMI continued to fare appreciably worse over the long-term.

It has been previously reported that patients with STEMI are treated more aggressively with various inpatient therapies that are not based on disease severity.Citation6 We similarly observed differences in the receipt of inpatient procedures and discharge medications according to AMI type. While these treatment practices may be accounted for by differential indications and current practice guidelines, it is possible that differences in treatment may have partially accounted for the improved long-term survival we observed in patients with STEMI. We did not, however, control for the receipt of either cardiac medications or coronary revascularization procedures in our regression models due to the significant potential for confounding by treatment indication in the context of this nonrandomized observational study. When we did, however, carry out a subgroup analysis in patients who underwent either a PCI or CABG surgery during hospitalization, patients with NSTEMI continued to experience higher all-cause death rates over our follow-up period than patients with STEMI.

The 1-year all-cause mortality rates for patients discharged from greater Worcester hospitals after STEMI (12%) and NSTEMI (24%) were slightly higher for STEMI, but considerably higher for NSTEMI, than what has been reported in prior investigations. A single-center observational study of patients with myocardial infarction undergoing PCI reported 1-year death rates of 9.5% and 14.3% for STEMI and NSTEMI, respectively.Citation7 A study of 1486 patients with AMI enrolled in the multicenter Dynamic Registry observed 1-year mortality rates of 7.3% for STEMI and 5.5% for NSTEMI,Citation20 while the 1-year death rates were 9.0% in STEMI patients and 11.6% in NSTEMI patients in the OPERA registry.Citation6 In the GUSTO-IIb trial, 1-year death rates were 9.6% for patients with STEMI and 11.1% for those with NSTEMI.Citation19

The discrepancies between these results and our findings are likely attributable to the advanced age and comorbid disease burden of patients in our community-based study as compared with those enrolled in other studies with different methodologies and more restrictive inclusion criteria,Citation19 or only patients studied at specialized medical centers.Citation7 Our findings may be more generalizable to the overall population of patients experiencing an AMI, and are important as they help to resolve the discrepancies in the results between other studies performed over a similar time period in more select patient populations.Citation7,Citation20 The present results lend further support to the notion that patients discharged from the hospital after NSTEMI constitute a high risk group in whom close surveillance and the use of evidence-based cardiac medications, where appropriate, is warranted.

Factors associated with increased mortality

In a multicenter study of patients hospitalized with AMI at 56 centers in France in the early 2000s, while advanced age, high heart rate on admission, and low levels of blood pressure at the time of hospital admission were independent, and similar, correlates of 1-year death rates in patients with STEMI or NSTEMI, differences in the predictability of several factors, or their strength of association, were observed in patients according to type of AMI.Citation6

Results of prior studies examining the association between sex and mortality after AMI have been conflicting, especially after controlling for age.Citation21,Citation22 In the present study, men were more likely to have died after hospital discharge for NSTEMI and STEMI.

Another important prognostic factor was the presence of renal dysfunction, which was associated with long-term mortality in both patient groups. Similarly, prior studies have demonstrated higher in-hospital, 30-day, and 3-year mortality rates in patients with AMI and renal impairment as compared to those with intact renal function.Citation23,Citation24 Renal impairment may increase mortality through multiple mechanisms, including a decreased likelihood of receiving appropriate therapies due to concern over an increased risk of bleeding or worsening renal function, drug toxicity, and endothelial dysfunction.Citation23,Citation24

The long-term mortality for patients with NSTEMI, in particular, has been related to the extent of their comorbid disease burden.Citation25 In the present study, patients with NSTEMI were more likely to have several comorbid diseases previously diagnosed, but patients with NSTEMI and STEMI were both found to have decreased survival if they had a history of heart failure. This is not surprising given the dismal long-term prognosis that is associated with this clinical syndrome.Citation26 Similarly, we found that a history of prior stroke was associated with decreased survival in both patient groups after hospital discharge. This finding is consistent with prior reports where AMI patients with prior stroke were treated less aggressively, and had higher rates of complications and inpatient and early post-discharge mortality, than patients without previously diagnosed stroke.Citation27

Interestingly, we found that patients with NSTEMI who presented with an elevated systolic blood pressure had reduced mortality. A registry study in Sweden also found that, among patients admitted to the intensive care unit with AMI, an elevated blood pressure was associated with reduced 1-year mortality.Citation28 Why a higher systolic blood pressure might be associated with improved outcomes for patients with AMI is unknown, but may reflect preserved myocardial function or absence of systemic hypoperfusion.

Despite similarities in some prognostic factors, there were also differences in the prognostic impact of several physiologic variables and in-hospital clinical complications between patients with STEMI and NSTEMI, with a number of these factors having a particularly adverse impact in those with NSTEMI. These findings suggest the need for greater surveillance, and intervention where appropriate, for high risk patients with NSTEMI.

Study strengths and limitations

The strengths of this study include its community-based perspective, its relatively contemporary population of patients hospitalized with AMI, and its large sample size. Our study has several limitations, however, that should be considered when interpreting the present results. The greater Worcester population is predominantly Caucasian and our findings may lack generalizability to other ethnic groups or communities of varying size. We were not able to comment on the influence that hospital and post-discharge treatment practices may have had on long-term prognosis since this was a nonrandomized observational study and we did not collect information about the receipt of different medication treatment regimens or coronary revascularization approaches after a patient’s discharge from all central Massachusetts hospitals. We were unable to further classify patients with AMI into a recently recommended schemaCitation29 and to satisfactorily assess, and by extension, analytically control for, other potentially important factors that may have influenced prognosis after AMI, such as infarct size, serum lipid or blood pressure levels, or presence of adverse lifestyle practices, such as cigarette smoking.

Conclusion

In this relatively contemporary cohort, patients with STEMI experienced a better post-discharge prognosis than those with NSTEMI. The factors associated with increased mortality for each of these patient groups were somewhat distinct, emphasizing the uniqueness of each disease category. Additional population-based surveillance efforts are needed to monitor recent trends in the natural history, functional status, and quality of life in patients further classified according to type of AMI. Studies leading to better understanding of the optimal inpatient and outpatient treatments based on AMI type and comorbid disease burden may maximize long-term outcomes for these patients.

Acknowledgments

This research was made possible by the cooperation of the cardiology and medical records departments of participating greater Worcester hospitals. Grant support was provided by the National Institute of Health (NIH) (RO1HL35434). Partial salary support for Drs Goldberg and McManus was provided for by NIH grant 1U01HL105268-01. Dr Darling was supported by NIH grant K23HL10199.

Disclosure

The authors report no conflicts of interest in this work.

References

  • Lloyd-JonesDAdamsRJBrownTMAmerican Heart Association Statistics Committee and Stroke Statistics SubcommitteeHeart disease and stroke statistics – 2010 update: a report from the American Heart AssociationCirculation20101217e46e21520019324
  • RossJJrElectorcardiographic ST-segment analysis in the characterization of myocardial ischemia and infarctionCirculation1976533 SupplI73I81767019
  • BraunwaldEAntmanEMBeasleyJWACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: executive summary and recommendations. A report of the American College of Cardiology/American Heart Association task force on practice guidelines (committee on the management of patients with unstable angina)Circulation2000102101193120910973852
  • BraunwaldEJonesRHMarkDBDiagnosing and managing unstable angina. Agency for Health Care Policy and ResearchCirculation19949016136228026048
  • AndersonJLAdamsCDAntmanEM2011 WRITING GROUP MEMBERS; ACCF/AHA TASK FORCE MEMBERS2011ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice GuidelinesCirculation201112318e426e57921444888
  • MontalescotGDallongevilleJVan BelleEOPERA InvestigatorsSTEMI and NSTEMI: are they so different? 1 year outcomes in acute myocardial infarction as defined by the ESC/ACC definition (the OPERA registry)Eur Heart J200728121409141717412730
  • ChanMYSunJLNewbyLKLong-term mortality of patients undergoing cardiac catheterization for ST-elevation and non-ST- elevation myocardial infarctionCirculation2009119243110311719506116
  • TerkelsenCJLassenJFNørgaardBLMortality rates in patients with ST-elevation vs non-ST-elevation acute myocardial infarction: observations from an unselected cohortEur Heart J2005261182615615795
  • CantorWJGoodmanSGCannonCPEarly cardiac catheterization is associated with lower mortality only among high-risk patients with ST- and non-ST-elevation acute coronary syndromes: observations from the OPUS-TIMI 16 trialAm Heart J2005149227528315846265
  • CoxDAStoneGWGrinesCLCADILLAC InvestigatorsComparative early and late outcomes after primary percutaneous coronary intervention in ST-segment elevation and non-ST-segment elevation acute myocardial infarction (from the CADILLAC trial)Am J Cardiol200698333133716860018
  • McManusDDGoreJYarzebskiJSpencerFLessardDGoldbergRJRecent trends in the incidence, treatment, and outcomes of patients with STEMI and NSTEMIAm J Med20111241404721187184
  • FloydKCYarzebskiJSpencerFAA 30-year perspective (1975–2005) into the changing landscape of patients hospitalized with initial acute myocardial infarction: Worcester Heart Attack StudyCirc Cardiovasc Qual Outcomes200922889520031820
  • GoldbergRJSpencerFAYarzebskiJA 25-year perspective into the changing landscape of patients hospitalized with acute myocardial infarction (the Worcester Heart Attack Study)Am J Cardiol200494111373137815566906
  • McManusDDChinaliMSaczynskiJS30-year trends in heart failure in patients hospitalized with acute myocardial infarctionAm J Cardiol2011107335335921256998
  • SaczynskiJSMcManusDZhouZTrends in atrial fibrillation complicating acute myocardial infarctionAm J Cardiol2009104216917419576341
  • GoldbergRJSpencerFAGoreJMLessardDYarzebskiJThirty year trends (1975–2005) in the magnitude of, management of, and hospital death rates associated with cardiogenic shock in patients with acute myocardial infarction: A population-based perspectiveCirculation200911991211121919237658
  • SaczynskiJSSpencerFAGoreJMTwenty-year trends in the incidence of stroke complicating acute myocardial infarction: The Worcester Heart Attack StudyArch Intern Med2008168192104211018955639
  • LinDWeiLJYingZChecking the Cox model with cumulative sums of martingale-based residualsBiometrika1993803557572
  • ArmstrongPWFuYChangWCAcute coronary syndromes in the GUSTO-IIb trial: prognostic insights and impact of recurrent ischemia. The GUSTO-IIb InvestigatorsCirculation19989818186018689799205
  • AbbottJDAhmedHNVlachosHASelzerFWilliamsDOComparison of outcome in patients with ST-elevation versus non-ST-elevation acute myocardial infarction treated with percutaneous coronary intervention (from the National Heart, Lung, and Blood Institute Dynamic Registry)Am J Cardiol2007100219019517631068
  • BergerJSElliottLGallupDSex differences in mortality following acute coronary syndromesJAMA2009302887488219706861
  • ChampneyKPFrederickPDBuenoHNRMI InvestigatorsThe joint contribution of sex, age and type of myocardial infarction on hospital mortality following acute myocardial infarctionHeart2009951189589919147625
  • FreemanRVMehtaRHAl BadrWCooperJVKline-RogersEEagleKAInfluence of concurrent renal dysfunction on outcomes of patients with acute coronary syndromes and implications of the use of glycoprotein IIb/IIIa inhibitorsJ Am Coll Cardiol200341571872412628712
  • AnavekarNSMcMurrayJJVelazquezEJRelation between renal dysfunction and cardiovascular outcomes after myocardial infarctionN Engl J Med2004351131285129515385655
  • AllenLAO’DonnellCJCamargoCAJrGiuglianoRPLloyd-JonesDMComparison of long-term mortality across the spectrum of acute coronary syndromesAm Heart J200615151065107116644337
  • GoldbergRJDarlingCJosephBEpidemiology of decompensated heart failure in a single community in the northeastern United StatesAm J Cardiol2009104337738219616671
  • CooperHADomanskiMJRosenbergYMagnesium in Coronaries trial investigatorsAcute ST-segment elevation myocardial infarction and prior stroke: an analysis from the Magnesium in Coronaries (MAGIC) trialAm Heart J200414861012101915632887
  • StenestrandUWijkmanMFredriksonMNystromFHAssociation between admission supine systolic blood pressure and 1-year mortality in patients admitted to the intensive care unit for acute chest painJAMA2010303121167117220332402
  • ThygesenKAlpertJSJaffeASSimoonsMLChaitmanBRWhiteHDThird universal definition of myocardial infarctionEur Heart J2012332551256722922414