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Case Report

Acetazolamide-induced cilio-choroidal effusion after cataract surgery: unusual posterior involvement

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Pages 33-36 | Published online: 23 Jan 2013

Abstract

Idiosyncratic reactions to a large number of drugs have been reported to cause choroidal detachment and secondary angle-closure glaucoma (ACG). We report a case of bilateral acute ACG and peculiar choroidal effusion following administration of oral acetazolamide immediately after cataract surgery. Few cases of acute secondary ACG with choroidal effusion and anterior shift of the lens-iris diaphragm have been associated with acetazolamide compared with other sulfonamides. As far as we are aware, posterior involvement with retinal folds and papillary edema due to acetazolamide has not been described before.

Introduction

Acetazolamide, a sulfonamide-derived medication, is frequently used in patients after cataract surgery.Citation1

It is a member of the class of antihypertensive drugs and is specifically indicated in the treatment of glaucoma, epilepsy, benign intracranial hypertension (pseudotumor cerebri), altitude sickness, cystinuria, and ectasia.Citation2Citation4 Acetazolamide acts as an inhibitor of the enzyme carbonic anhydrase and is therefore applied in ophthalmology to control primary or postsurgical secondary ocular hypertension.Citation5

This medication and other sulfa drugs have been documented to cause, very rarely, idiosyncratic reactions characterized by transient myopia, ciliary body edema, uveal effusions, and anterior rotation of the lens-iris diaphragm, which causes secondary angle-closure glaucoma (ACG).Citation6 Unfortunately, the angle closure occurs without pupillary block, so that topical miotics and peripheral iridectomy are not helpful.Citation7 In contrast, stopping the offending agent and controlling the intraocular pressure (IOP) with the administration of drugs allows rapid resolution of signs and symptoms. This reaction has been frequently documented after topiramate administration, an antiepileptic agent also used to treat migraine,Citation8,Citation9 while only rarely after acetazolamide.Citation10Citation12

Here, we report a case of ciliary body edema after administration of acetazolamide causing bilateral ACG, as already described in the literature.Citation11,Citation12 However, in our case we found a massive choroidal effusion with posterior retinal folds and papillary edema. The existent literature reporting ciliary body edema after administration of acetazolamide do not describe these features at the posterior pole.Citation6Citation13

Case report

A 71-year-old white male had routine cataract surgery and intraocular lens implantation under local anesthetic in his right eye (RE) in the late afternoon. He was prescribed a single oral dose of acetazolamide (250 mg) before sleeping to prevent rise of IOP. The patient took the acetazolamide pill at 11 pm (4 hours after cataract surgery). About 3 hours later, he woke up because of severe pain and found he had reduced vision in both eyes, so was referred to our first-aid hospital.

Upon examination, the patient’s best-corrected visual acuity was 3/50 in the RE and 2/50 in left eye (LE), with corrections of −4.50 D in the RE and −1.25 D in the LE. Both eyes showed congestion and edema of the inferior bulbar conjunctiva, heavy cloudy cornea, and a very shallow anterior chamber (). The intraocular lens was shifted forward. IOP was 52 mmHg in the RE and 60 mmHg in the LE. Gonioscopy revealed 360-degree appositional angle closure with a convex iris configuration in both eyes. Fundus examination was impossible due to opaque media. A diagnosis of ACG was made and the patient was admitted to the hospital. He was immediately administered mannitol 2 mg/kg intravenously and acetazolamide orally, together with topical steroids and β-blockers.

Figure 1 Anterior segment of the left and right eye (which underwent cataract surgery) showing the absence of the anterior chamber, observed during slit lamp examination, and choroidal congestion.

Abbreviations: OD, oculus dexter; OS, oculus sinister.
Figure 1 Anterior segment of the left and right eye (which underwent cataract surgery) showing the absence of the anterior chamber, observed during slit lamp examination, and choroidal congestion.

Later in the morning, his IOP was 32 mmHg in the RE and 36 mm Hg in the LE. Nd:YAG laser iridotomy was performed in the LE, but had a poor effect on anterior chamber depth and ocular hypertension.

B-scan ultrasonography () showed bilateral choroidal effusion with forward displacement of the anterior segment. Fundus examination was characterized by bilateral peripheral choroidal detachment () and papillary swelling. Posterior optical coherence tomography scans confirmed papillary edema () together with retinal folds and nerve fiber layer thickening.

Figure 2 B-scan ultrasonography showing choroidal effusion and chorioretinal detachment.

Figure 2 B-scan ultrasonography showing choroidal effusion and chorioretinal detachment.

Figure 3 Choroidal detachment observed during fundus examination using indirect Schepens ophthalmoscopy.

Abbreviations: OD, oculus dexter; OS, oculus sinister.
Figure 3 Choroidal detachment observed during fundus examination using indirect Schepens ophthalmoscopy.

Figure 4 Papillary edema and nerve fiber layer thickening observed during optical coherence tomography examination (right eye).

Figure 4 Papillary edema and nerve fiber layer thickening observed during optical coherence tomography examination (right eye).

Acetazolamide was suspected as the cause of the bilateral angle closure, thus was discontinued. The clinical manifestations gradually improved and, 3 days later, the patient’s IOP was 14 mmHg in the RE and 16 mmHg in the LE, his best-corrected visual acuity was 10/10 in the RE and 7/10 in the LE (because of pre-existing lens opacities), and the myopic shift had receded.

A month later, the patient underwent cataract surgery of the LE without the use of any sulfonamide medication and, as evidenced by optical coherence tomography scans, had no complications.

Discussion

Few cases of acute secondary ACG with choroidal effusion and anterior shift of the lens-iris diaphragm have been associated with acetazolamide compared with other sulfonamidesCitation6,Citation10Citation12 and there have been only a few reports of posterior retinal-fold involvement due to topiramate and hydrochlorothiazide.Citation13,Citation14 As far as the authors are aware, papillary edema has never been reported associated with sulfa drugs and posterior involvement with retinal folds and papillary edema due to acetazolamide has not been described.

The retinal folds in our patient were caused by the action of the retinal pigment epithelium inhibiting further progression of fluid from the choroidal space into the retina and inextensible scleral coat. His papillary edema was caused by the absence of any barrier in the prelaminar region that could inhibit the diffusion of fluid from the choroid into the papilla and peripapillary region. This fluid diffusion was also responsible for the nerve fiber layer thickening.

Acetazolamide can cause a paradoxical adverse reaction, provoking cilio-choroidal effusion and massive involvement of the anterior and posterior segment.Citation6Citation14

Although topical formulations of carbonic anhydrase enzyme inhibitors, such as dorzolamide, have been developed,Citation15 we chose to administer oral acetazolamide because of its well-known ability to reduce acute elevated IOP. As acute elevated IOP is sight threatening, this justified the administration of the acetazolamide, with its associated risk of rare ocular and systemic side effects. Indeed, topical dorzolamide acts only on the carbonic anhydrase enzymes present in ciliary processes of the eye, reducing aqueous flow by 17% and IOP by up to 23% as monotherapy.Citation16Citation19 In contrast, acetazolamide alone reduces these parameters by 30%Citation16Citation19 thanks to its diuretic properties and indirect osmotic effect that leads to vitreous dehydration together with hyperosmotic agents. Furthermore, it has been shown to act on the outward permeability of the blood–retina barrier.Citation20

In prescribing acetazolamide, all specialists and general practitioners should be aware of this side effect of the drug and refer patients to ophthalmologists. At the same time, ophthalmologists should be able, by obtaining an accurate case history, to make a correct differential diagnosis between primary acute ACG and this rare secondary pharmacological adverse reaction.

Disclosure

The authors declare no conflicts of interest in this work.

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