Application of the Care Bundle in Perioperative Nursing Care of the Type A Aortic Dissection

Abstract

Background

To investigate the effect of the care bundle in the nursing care of the type A aortic dissection (TAAD).

Methods

A total of 161 patients with TAAD were included in the study. They were divided into control group (n=79) and care bundle group (n=82). The patients in the control group received routine nursing, while the patients in the care bundle group received routine nursing and care bundle. IL-2, IL-6 and IL-10 levels in the three periods of T0 (before anesthesia), T1 (before anesthesia to 6 h after surgery) and T2 (6–24 h after surgery), intraoperative blood loss, postoperative recovery, ICU stay time, intraoperative pressure ulcer rate, postoperative delirium rate, bloodstream infection rate and doctor satisfaction.

Results

The postoperative T and pH levels in two groups were all in the normal range. The levels of IL-2, IL-6 and IL-10 in the care bundle group at different periods were also significantly different. The levels of IL-2 and IL-10 showed an increased trend, while that of IL-6 showed a downward trend. The intraoperative blood loss, postoperative recovery and ICU stay time, intraoperative pressure sore rate, postoperative delirium rate, and bloodstream infection rate were lower, whereas doctor satisfaction was all significantly higher in care bundle group.

Conclusion

Care bundle increased the safety of the operation, and it was beneficial to the postoperative rehabilitation for TAAD patients.

Relevance to Clinical Practice

Patients with TAAD who underwent operation need higher quality care during the entire operation. Cluster nursing is the kind of the nursing model that can better meet the requirements of the intraoperative nursing quality. The intervention methods in this study include 5 core nursing measures. These measures are implemented together in a synergistic manner to effectively improve the quality of nursing care in operating room and the health outcomes of patients with TAAD. Care bundle is worthy of clinical application.

Keywords:

• care bundle
• nursing care
• type A aortic dissection

Plain Language Summary

What is the contribution of this study to the wider global clinical community?

1. Care bundle is beneficial to nursing care of TAAD treatment.

2. Care bundle can effectively promote the recovery of patients.

3. Care bundle is worthy of clinical application.

Introduction

Acute aortic dissection (AAD) is a pathological change with a double-lumen dissection (true and false lumen). AAD can be divided into type A and type B according to the Stanford classification.¹ Type A aortic dissection (TAAD) involves the ascending aorta with rapid progress.² Epidemiology studies show a statistical incidence in Europe of approximately 2–16 cases/100,000 inhabitants/year.³ The 48-h mortality is about 50%, and the 2-week mortality is about 75%.⁴ TAAD has a wide range of lesions involving many important organs. Currently, surgery is still the recommended treatment for TAAD. However, it is difficult to operate, and has a relatively high incidence of postoperative complications.⁵ The most common predisposing factor for AAD patients is hypertension, and nearly 80% of AD patients suffer from hypertension.⁶ During the perioperative period, it is necessary to stabilize the patients’ blood pressure to reduce the sheer force of the blood flow on the aortic wall. In the Guidelines for Diagnosis and Treatment of Aortic Diseases issued by the European Society of Cardiology in 2014⁷ it has pointed out that in early phase of AAD, if systolic blood pressure (SBP) is controlled at 100–120 mmHg and heart rate (HR) is controlled at 60–70 beats/min, it can prevent further expansion of interlayer tears and reduce mortality. Moreover, inflammatory response also plays an important role in the formation of AAD.^8–10 IL-2, IL-6 and IL-10 are important indicators to evaluate the immune status of the body. IL-2 has anti-tumor and anti-infection effects through participating in the activation and proliferation of B lymphocytes and the proliferation of cytotoxic T cells.¹¹ During the pathogenesis of TAAD, IL-6 infiltrates the aortic wall and eventually lead to a systemic inflammatory response.¹² IL-10 is a multi-potent anti-inflammatory cytokine secreted, which can inhibit tumor necrosis factor C and other cytokines secreted by Th1 subtype cells.¹³

The key to successful surgery depends not only on the surgeon’s skill, but also on the quality of care. Therefore, the operating room nursing team faces certain challenges. The intraoperative pressure ulcers are more likely to occur due to the relatively unstable circulation status of patients with AD during surgery and the long operation time.¹⁴ Implementing skin protection measures for AD patients is an important nursing measure to prevent postoperative infections and promote postoperative recovery.

The concept of the care bundle was firstly proposed by the Institute for Healthcare Improvement (IHI, USA) in 2001.¹⁵ It points out that the care bundle includes 3–5 evidence-based, interrelated, simple and operable practice measures. At present, care bundle has been applied to prevent ventilator-associated pneumonia and central line-associated blood-stream infection, and has achieved significant effects.^16,17 Huang et al¹⁸ applied the care bundle to the preoperative care of AAD patients and found that it significantly reduced the incidence of AD rupture. However, the effect of care bundle in the nursing care of TAAD in entire surgical treatment process is still unclear. Therefore, the purpose of this study was to investigate the effect of care bundle in the nursing care of TAAD.

Methods

Subjects

The study was conducted in accordance with the Declaration of Helsinki and reviewed and approved by the Ethics Committee of the Xinjiang Medical University. Written informed consent was obtained from every patient. A total of 161 patients with TAAD who underwent surgery in the Xinjiang Medical University from January 2018 to December 2019 were included in the study. According to the time we performed different nursing care, 79 patients who underwent surgery from January 2018 to December 2018 were considered as control group, and 82 patients who underwent surgery from January 2019 and December 2019 were considered as care bundle group. They underwent total arch replacement and ascending aortic replacement. The patients in the control group received routine nursing, while the patients in the care bundle group received routine nursing and care bundle. Inclusion criteria: 1) patients who met the diagnostic criteria of acute TAAD;¹⁹ (2) patients who received surgical treatment; (3) patients with acute TAAD caused by hypertension. Patients combined with other diseases were excluded.

Routine Care

Briefly, one specialist nurse was arranged to cardiac operating room. The patient’s SBP was reduced to 110–120 mmHg before surgery, and no time limit was set. The heating blanket was adjusted to 36°C for rewarming until the anal temperature was ≥36°C. A foam dressing was applied for skin protection according to the condition of the patient and the operation time.

Care Bundle

Multidisciplinary Collaboration

The treatment group consisted of cardiac surgeons, anesthesiologists, CBP technicians, specialist nurses, material specialists and ICU nurses.²⁰ Combined with the admission process of AD patients and the supply of surgical materials, the reasons for the failure rate of operation were summarized based on brainstorming method. After literature search and screening and multiple revisions, a feasible care bundle plan was made.

Emergency Initiation

The green emergency channel was activated for AD patients. The surgeon informed the operating room and the anesthesiology department to coordinate the operating room and prepare the surgical materials 1 h in advance, and then the specialist nursing team members were responsible. They had completed the constantly updated learning plan as scheduled with multimedia, video, MOC and other learning channels.

Blood Pressure Control

A quiet and comfortable environment was provided. With the goal of “quiet, painless, SBP of 110 to 120 mmHg, HR below 70 beats/min”, AD patients were required to lower their blood pressure to the target value within 5 to 10 min.²¹ In the perioperative period, the blood pressure management model of the integration of surgeon, nurse and patients²² was implemented. During the transfer process of AD patients, medical staff should cooperate with each other to reduce waiting time, closely observe the condition, shorten the transfer path, and handle it carefully.

Body Temperature Modulation

Multiple pre-warming measures were used to adjust the patients’ body temperature, including opening the 100-level operation room 30 min before the operation and adjusting the temperature to 22~24°C.²³ The medical electric blanket or water circulation heating blanket was placed on the operating bed. The inflatable insulation blanket was placed under the patient’s lower limbs. When the CBP began, the room temperature was adjusted to 18–20°C and an ice cap was used. When the CBP stopped, the room temperature was adjusted to 24–26°C. After the temperature of the anal canal raised to 32°C, the ice cap was removed and the electric blanket or heating water blanket and inflatable insulation blanket were turned on. The set temperature of the blanket should be 5°C lower than the patient’s rectal temperature to avoid low-temperature burns. Heated wet dressing was used if necessary. Meanwhile, the infusion warmer was adjusted to 36–37°C to heat input fluid until the temperature of the anus or the nasopharynx was ≥36°C.

Skin Protection

The special skin care included evaluation of pressure ulcers, laying cotton pads, applying colloids, adhering dressings, moderate lifting, dynamic inspection and handover inspection and restoring normal body temperature. Foam dressings were applied to the head, shoulders, sacral tail and heels that are prone to pressure sores.²⁴ If possible, patients were gently lifted for 10 min at an interval of about 1 h.

General Indicators

The values of HR, SBP, diastolic blood pressure (DBP), core temperature (T) and pH were recorded before and after operation. Blood pressure was measured by puncturing the left and right radial artery and dorsal plantar artery. HR was read by pulse oxygen. T indicated nasopharyngeal temperature or anal temperature. pH value was measured using the blood gas analyzer. Intraoperative blood loss was calculated based on the blood container and dressing blood storage. Intraoperative pressure ulcers were assessed according to pressure ulcer classification criteria.²⁵

Enzyme Linked Immunosorbent Assay (ELISA)

Peripheral venous blood (3 mL) was collected at three time points of T0 (before anesthesia), T1 (before anesthesia-6h after operation) and T2 (6–24 h after operation). Plasma was obtained after centrifugation. Quantitative determination of the levels of IL-2, IL-6 and IL-10 in plasma was performed by ELISA.

Surgical Prognostic Indexes

Postoperative recovery time referred to the time from the end of operation to the recovery of patients’ consciousness. ICU stay time was the period from the end of operation to transfer-out from ICU. Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) was used to determine the incidence of delirium in postoperative patients.²⁶ According to the postoperative axillary temperature >37.5°C and abnormal blood items, the postoperative blood flow infection was determined according to the postoperative axillary temperature of >37.5°C and the abnormal results of blood routine examination.

Doctor Satisfaction Survey

The questionnaire for doctor satisfaction developed by Du et al²⁷ was used. The reliability and validity of the questionnaire were both greater than 0.7. It contained 5 items, including material supply, professional technology, work efficiency, emergency handling, and communication and collaboration. The Cronbach's coefficient was 0.802. Satisfaction was divided into very satisfied, satisfied and dissatisfied. Totally, 29 questionnaires were issued and 29 were returned, with a recovery rate of 100%.

Statistical Analysis

Statistical analysis was performed using SPSS 25.0 statistical software package. The measurement data with normal distribution were expressed as means ± standard deviation (SD) and analyzed using paired independent sample t-test or ANOVA. The counting data were described as frequency and analyzed using χ² test or Fisher’s exact test. A P value less than 0.05 was considered as statistically significant.

Results

Comparison of the Indicators Before and After Operation

There were 130 males and 31 females. They were aged 42–68 (51.36±7.12) years old. There were no significant differences in the clinical data between the two groups (Table 1). Moreover, there was no significant difference in HR between the two groups (P>0.05). The levels of SBP and DBP before and after operation were statistically different between within-groups and between the two groups (P<0.05). There were no statistical differences in T and pH between within-groups (P>0.05). However, the differences in postoperative SBP, DBP, T and pH between the two groups were statistically significant (P<0.05) (Table 2). These results indicated that the care bundle intervention was conducive to stabilizing the basic indexes.

Table 1 Comparison of the General Information of the Two Groups

Clinical Information	Care Bundle Group	Control Group	t/χ^2	P
Age (years old)	53.75±6.03	51.30±4.57	0.760	0.389
Sex
Male	68	62	0.551	0.303
Female	14	17
Body mass index (kg/m^2)	26.16 ± 4.49	25.4 2± 2.65	0.627	0.433
History of hypertension	71 (86.6)	67 (84.8)	0.824	0.461
History of diabetes	2 (2.4)	3 (3.8)	0.678	0.482
History of cardiovascular surgery	1 (1.2)	1 (1.3)	1.000	0.742
Preoperative APACHE II score	14.30±1.45	14.85±1.53	0.005	0.942

Abbreviation: APACHE, acute physiology and chronic health evaluation.

Table 2 Comparison of Indexes Between Within-Groups or Between Two Groups Before and After Operation

Group	Time	HR/min	SBP/mmHg	DBP/mmHg	T/°C	pH
Care bundle group	Before operation	73.85±3.73	161.55±4.58	91.25±5.79	36.81±0.53	7.40±0.04
	After operation	74.40±5.79	110.34±5.97*	72.05±3.62*	36.87±0.46**	7.39±0.03*
t		9.089	38.001	18.412	−1.924	−0.909
P		0.076	<0.01	<0.01	0.06	0.373
Control group	Before operation	73.03±4.22	160.47±5.98	90.93±4.56	36.78±0.54	7.38±0.08
	After operation	74.28±5.12	111.62±4.96	72.84±5.57	36.77±0.41	7.37±0.01
t		7.382	36.012	11.371	6.773	−0.112
P		0.231	0.016	<0.01	0.12	0.912

Notes: Comparison of the postoperative indexes between the two groups, *P < 0.05 and **P < 0.01.

Abbreviations: HR, heart rate; SBP, systolic pressure; DBP, diastolic pressure; T, core temperature.

Comparison of Interleukin Levels Between the Two Groups

To explore the inflammatory response, serum interleukin levels were measured by ELISA. At T1, the levels of IL-2 and IL-10 in the care bundle group were higher than those in the control group, while IL-6 level was lower than the control group (P<0.05). The levels of IL-2, IL-6 and IL-10 at T0, T1 and T2 in the care bundle group were statistically different (P<0.05). The levels of IL-2 and IL-10 showed increasing trends, and IL-6 level showed a downward trend. There were no significant differences in the levels of IL-2 and IL-10 between T1 and T2 (P>0.05). There were no significant differences in the levels of IL-2 and IL-6 in the control group among the periods of T0, T1 and T2. However, IL-10 level was significantly different, showing a trend of first increasing and then decreasing (Table 3).

Table 3 Comparison of the Interleukin Levels Between the Two Groups

Items	Time	Care Bundle Group	Control Group	t	P
IL-2 (ng/L)	T0	149.38±33.23	125.98±36.81	0.030	0.863
	T1	160.63±38.93	145.33±31.68	5.801	0.017
	T2	164.15±32.91	147.48±36.73	1.829	0.167
	F	6.163	1.897
	P	0.002	0.152
IL-6 (ng/L)	T0	51.10±15.21	49.02±16.61	1.829	0.178
	T1	43.15±14.62	47.75±15.66	7.676	0.006
	T2	45.64±12.26	45.04±14.10	2.396	0.124
	F	6.449	0.895
	P	0.002	0.41
IL-10 (ng/L)	T0	134.93±39.51	127.05±20.94	0.525	0.471
	T1	156.19±48.18	143.19±32.14	10.312	0.002
	T2	162.23±46.36	127.24±33.95	0.111	0.740
	F	11.291	15.395
	P	<0.01	<0.01

Comparison of the Intraoperative Blood Loss, Recovery Time and ICU Stay Time Between the Two Groups

To explore the changes of the prognostic indexes of operation, the monitoring of relevant indicators was performed. The intraoperative blood loss, postoperative recovery time and ICU stay time in the care bundle group were significantly lower than control group (P<0.05) (Table 4). These results indicated that the care bundle intervention may improve the prognosis.

Table 4 Comparison of the Intraoperative Blood Loss, Recovery Time and ICU Stay Time Between the Two Groups

Item	Care Bundle Group	Control Group	t	P
Intraoperative blood loss (mL)	1761.22±516.09	2310.76±641.37	18.138	<0.01
Postoperative recovery time (h)	16.98±1.63	22.70±1.99	6.256	0.013
ICU stay time (d)	6.24±1.44	12.83±1.64	4.182	0.042

Comparison of Complications Between the Two Groups

The postoperative complications were also evaluated. The intraoperative pressure ulcers, postoperative delirium and postoperative bloodstream infections in the care bundle group were significantly lower than control group (P<0.05) (Table 5). These results indicated that the care bundle intervention may decrease the incidences of postoperative complications.

Table 5 Comparison of the Complications Between the Two Groups

Groups	Number	Intraoperative Pressure Ulcer (n, %)		Postoperative Delirium (n, %)		Postoperative Bloodstream Infection (n, %)
		Yes	No	Yes	No	Yes	No
Care bundle group	82	4 (4.9)	78 (95.1)	12 (14.6)	70 (85.4)	2 (2.4)	80 (97.6)
Control group	79	13 (16.5)	66 (83.5)	21 (26.6)	58 (73.4)	9 (11.4)	70 (88.6)
χ^2		5.711		6.464		5.067
P		0.015		0.011		0.024

Comparison of Doctor Satisfaction Between the Two Groups

To investigate the satisfaction of doctor with the nursing work, the questionnaire investigation of doctor satisfaction was performed. The ratios of “very satisfied” in the care bundle group and the control group were 75.9% and 42.4%, respectively (χ2=7.132, P=0.028) (Table 6). These results indicated that the care bundle intervention method could improve the satisfaction of doctors.

Table 6 Comparison of the Doctor Satisfaction Between the Two Groups

Groups	Number	Satisfaction (n,%)
		Very Satisfied	Satisfied	Dissatisfied
Care bundle group	29	22 (75.9)	6 (20.7)	1 (3.44)
Control group	29	12 (42.4)	15 (51.7)	2 (6.9)
χ^2		7.132
P		0.028

Discussion

Our results showed that there was no statistically significant difference in HR before and after surgery between the two groups, indicating that the care bundle intervention had no significant effect on the HR in AD patients. The postoperative SBP and DBP levels in the two groups were lower than the preoperative values, and the postoperative SBP and DBP levels in the care bundle group were lower than control group (P<0.05). It indicated that the perioperative blood pressure in the two groups was controlled to a certain extent and reached or approached to normal ranges. The blood pressure control in the care bundle group was more effective than the control group.

The care bundle for the nursing care of AD patients involves not only the aspects of medical technology, monitoring skills and nursing practice, but also the perspective of humanistic care. According to the onset characteristics of AD patients, emotional support and a quiet and comfortable medical environment are used to reduce blood pressure rise caused by pain and anxiety.²⁸ The target goal of blood pressure control was set, and an infusion micro-pump was used to inject vasoactive drugs to control blood pressure. A three-in-one integrated blood pressure management model,²⁹ including the doctors, nurses and patients, was implemented during the perioperative period. They will work together to keep the patient’s blood pressure at a stable level, which is the primary guarantee for successful surgery. It has been reported that the appliance this model has significantly improved the blood pressure control and the satisfaction of the medical staff with the work flow.³⁰ This conclusion is consistent with the results of this study, indicating that the blood pressure control strategy in our study has good effect.

AD surgery needs to be performed with the support of CPB. When establishing CPB, it is necessary to reduce the patient’s body temperature to moderate hypothermia, which provides effective brain protection and does not increase the complications of spinal cord and abdominal organs.³¹ When the blood vessel replacement is completed, the circulation is opened, and the heart needs to be warmed up to the normal body temperature range for the re-beating. Although this can be achieved by an extracorporeal circulation machine, comprehensive rewarming measures must be taken before the rectal temperature and nasopharyngeal temperature ≥36°C to fully ensure the timeliness of adjustment and prevent various complications caused by intraoperative hypothermia.³² Our results showed that the postoperative T and the pH value were different between the two groups, indicating that the integrated rewarming method in the care bundle can effectively maintain the T and PH value of AD patients during and after operation. Local aortic intima tearing and bleeding form intermural hematoma, which is prone to secondary damage to the patient due to secondary systemic pathophysiological changes, including secondary bleeding, low temperature, acidosis, and a vicious circle.³³ Therefore, it is essential to actively prevent hypothermia. The comprehensive rewarming method has played a positive role in the control of T and PH in AD patients. The results of this study showed that the intraoperative bleeding volume in the care bundle group was lower than control group. This indicated that blood pressure control and intraoperative rewarming strategies cooperate with each other to reduce the blood vessel pressure caused by hypertension, thus reducing bleeding. Moreover, the normal body temperature maintained by rewarming can maintain the activity of various coagulation factors, prothrombin and platelets to effectively reduce the amount of bleeding. It is consistent with the conclusion of Wavra et al.³⁴ Emergency surgery for ATAAD is associated with high risk for PTSD because of high blood pressure and pre-existing diseases of the aorta, which seems to negatively affect physical and mental well-being.³⁵

During AD surgery, the application of CPB, deep hypothermia circulatory arrest and large amounts of blood product infusion will lead to further aggravation of inflammation and coagulation disorders. Cytokines of IL-2, IL-6 and IL-10 are important indicators to evaluate the immune status of the body.³⁶ Comprehensive rewarming can cause benign changes in cytokine levels, to a certain extent, inhibit the perioperative inflammatory response in AD patients, thereby reducing the incidence of infection and the risk of organ dysfunction.³⁷ Our results showed that the levels of IL-2 and IL-10 were higher while IL-6 level was lower in the care bundle group than control group. The levels of IL-2 and IL-10 showed an increasing trend, while IL-6 showed a downward trend in the care bundle group in T0, T1 and T2. In the control group, there were no significant differences in IL-2 and IL-6 levels in the three periods, while IL-10 levels showed an increasing trend at first and then decreasing. Thus, the comprehensive rewarming in care bundle intervention can promote the secretion of IL-2 and IL-10 and reduce the secretion of IL-6. IL-10 can inhibit the infiltration of lymphocytes and neutrophils, which is essential for the balance of the body’s inflammatory response.¹³ IL-6 can infiltrate the aortic wall and eventually lead to systemic inflammatory response.¹² Therefore, the increased IL-2 and IL-10 levels and decreased IL-6 level have a certain inhibitory effect on the inflammation induced by the pathological characteristics of AD and the hypothermic cycle. The levels of IL-2, IL-6 and IL-10 in T1 period showed significant differences between the two groups. T1 is the most critical perioperative period of AD.³⁸ Due to the large surgical trauma, heavy blood loss and low-temperature perfusion, it is easy to destroy the normal functional metabolism.^39,40 Within 6 h after the operation, the body needs to adjust the immune system to prevent the inflammatory reaction to reach the balance of the internal environment, which is closely related to postoperative recovery.³⁷

The results of the present study also showed that in the care bundle group, the bloodstream infection rate, the incidences of postoperative delirium and the postoperative recovery time were all significantly lower than control group. By maintaining body temperature, the normal circulation functions of important organs are guaranteed, which facilitates the metabolism of anesthetic drugs, effectively shortens the postoperative recovery time, and reduces the incidence of postoperative delirium.^41,42 The ICU stay time in the care bundle group was shorter than that in the control group, which was closely related to the improvement of nursing team’s overall professional ability.

Due to the establishment of CBP and hemodynamic changes,¹⁴ hypothermia treatment and subsequent rewarming process induced ischemia-reperfusion injury⁴³ and ischemia and hypoxia caused by circulatory-arrest-induced poor tissue perfusion⁴⁴ that are two high-risk factors for the occurrence of pressure ulcers in cardiovascular surgery. The incidence of stress injury in patients undergoing cardiovascular surgery reaches 24.8%.⁴⁵ Stress injury may increase the physical and mental pain, prolong the recovery time, increase the workload of medical care, and result in additional costs.⁴⁶ The specialist nursing team in this study implemented a special model for the prevention of pressure ulcers, containing 7 elements. Consistent with previous studies,^47–49 we showed that the intraoperative pressure ulcer rate in the care bundle group was significantly lower than control group, indicating that this skin protection model was effective in preventing AD operative pressure ulcers and could significantly reduce the incidence of pressure ulcers, thereby reducing postoperative complications. Furthermore, doctor satisfaction in the care bundle group was higher than control group, which was consistent with previous researches.^15,50,51 They believed that it was very important to strengthen the training of nurses’ comprehensive quality, such as theoretical knowledge, operation technology, risk awareness and emergency ability.

There are also some limitations in this study. First, the sample size is small. Second, only TAAD patients were included. The data may not be generalized to patients with other types of AS. Further studies with larger sample sizes are needed.

Conclusions

In the care bundle group, the HR value was stable before and after the operation, the SBP and DBP levels were decreased significantly, and the core temperature and pH value remained stable. In the care bundle group, the levels of IL-2 and IL-10 were increased, IL-6 level was decreased, and the intraoperative blood loss, incidence of pressure ulcers, postoperative delirium, bloodstream infection, recovery time and ICU stay time were all decreased. However, the doctor satisfaction was increased in the care bundle group. Therefore, care bundle is beneficial to nursing care of AD surgical treatment and can effectively promote recovery of AD patients.

Relevance to Clinical Practice

Cluster nursing has been applied in Aortic dissection surgery. It can effectively ensure the stability of intraoperative life indications and reduce the postoperative complications. Meanwhile, it can promote collaboration between doctors and nurses to give full play to team effectiveness. The rescue time of patients with TAAD is effectively shortened. The patient’s blood pressure is more stable. The patients’ temperature can be properly controlled according to the course of surgery. The skin is protected. In conclusion, the safety of patients is fully guaranteed.

Abbreviations

TAAD, type A aortic dissection; HR, heart rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; T, temperature; AD, aortic dissection; SBP, systolic blood pressure; IHI, Institute for Healthcare Improvement; ELISA, Enzyme linked immunosorbent assay; CAM-ICU, Confusion Assessment Method for the Intensive Care Unit; SD, standard deviation.

Ethics Approval and Consent to Participate

The study was reviewed and approved by the Ethics Committee of the Xinjiang Medical University. Written informed consent was obtained from every patient. A total of 161 patients with TAAD who underwent surgery in the Xinjiang Medical University from January 2018 to December 2019 were included in the study.

Author Contributions

LL is responsible for the guarantor of integrity of the entire study, study concepts and design, definition of intellectual content, literature research, clinical studies, experimental studies, data analysis, statistical analysis, manuscript preparation and editing and review; JQZ is responsible for the literature research, clinical studies, experimental studies, data acquisition; LKL and XQC are responsible for the data acquisition; YLL is responsible for the guarantor of integrity of the entire study, data analysis, statistical analysis, manuscript review. All authors contributed to data analysis, drafting or revising the article, gave final approval of the version to be published, agreed to the submitted journal, and agree to be accountable for all aspects of the work.

Disclosure

There are no potential conflicts of interest to disclose.

Additional information

Funding

This study was funded by the Natural Science Foundation of Xinjiang Uygur Autonomous Region (Grant No. 2016D01C259).