Trends in Hospital Admission Due to Diseases of the Eye and Adnexa in the Past Two Decades in England and Wales: An Ecological Study

Abstract

Purpose

To investigate the trends of hospital admissions concerning diseases of the eye and adnexa in the United Kingdom in the past 20 years.

Materials and Methods

An ecological study was conducted using hospital admission data taken from the Hospital Episode Statistics database in England and the Patient Episode Database for Wales. Hospital admissions data for diseases of the eye and adnexa were extracted for the period between April 1999 and March 2019. The trend in hospital admissions was assessed using a Poisson model.

Results

Hospital admission rate for diseases of the eye and adnexa increased by 73.8% [from 7.48 (95% CI 7.45–7.50) in 1999 to 13.00 (95% CI 12.97–13.02) in 2019 per 1000 persons, trend test, p < 0.001]. The most common cause of hospitalisation for diseases of the eye and adnexa was disorders of the lens (62.3%), followed by disorders of the choroid and retina (14.2%), followed by disorders of the eyelid, lacrimal system and orbit (11.5%). Hospital admission rate among males increased by 91.2% [from 6.19 (95% CI 6.16–6.22) in 1999 to 11.83 (95% CI 11.80–11.87) in 2019 per 1000 persons]. Hospital admission rate among females increased less sharply by 63.2% [from 8.71 (95% CI 8.68–8.75) in 1999 to 14.22 (95% CI 14.18–14.26) in 2019 per 1000 persons].

Conclusion

There are clear gender and age trends in the epidemiology of hospital admissions related to eye and adnexa disorders. Further observational studies are warranted to identify other risk factors for these important causes of hospitalisation and understanding of differential trends.

Keywords:

• admission rate
• adnexa
• ecological study
• England
• eye
• hospitalisation
• United Kingdom
• Wales

Introduction

Untreated eye diseases, particularly cataracts,¹ are considered the principal cause of blindness worldwide. The majority of people with visual impairment are elderly and fall in the age group 50 years and above. More than 80% of people in this age group suffer from eye diseases.² The United Kingdom (UK) ranked number four after Russia, Turkey, and Germany in Europe and number 21 worldwide in the list of countries by population, with an estimated population of 67,886,011 people (about 0.87% of the total world population) in 2020, according to the United Nations (UN) data. The UK population in mid-2019 was 66,796,807, of which 59,439,840 (89.0%) were living in England and Wales. Between 1999 and 2020, the UK population increased by 9,170,157 (the estimated number was 58,715,854 in 1999).^3,4 In the UK, in 2000, the median age was 37.6 years, reaching 40.5 in 2020 with a dramatic increase by 0.73 years every five years. Similarly, the life expectancy increased from 80.6 and 76.1 years in 2000 to 83.3 and 80.2 years in 2020 for females and males, respectively (the average increase was 0.68 and 1.03 years every five years for females and males, respectively).⁴ Both the large population and high life expectancy increase the demands on health services as older people are more prone to develop chronic illnesses with multiple morbidities, including age-related eye diseases and associated visual impairment.^5,6

Ocular adnexa is a term given to the accessory structures attached to, close to, or surrounding the eye. They include eyelids, eyelashes, conjunctiva, extraocular muscles, lacrimal apparatus, and orbit.^7,8 The eyes and adnexa are subject to several conditions due to congenital, developmental, structural, metabolic, autoimmune, infectious, inflammatory, traumatic, degenerative, and neoplastic disorders. Diseases that affect the globe and its surrounding tissues may present diagnostic and therapeutic challenges to health-care providers, especially ophthalmologists and dermatologists.⁹ Careful observation and extensive knowledge of the most frequent diseases of the eye and adnexa, which lead to early detection, diagnosis, and management of ocular diseases, are crucial for establishing the desired outcomes.

Nowadays, the advancement in treating eye conditions has decreased the incidence of ocular complications, such as complications related to diabetic retinopathy.^6,10,11 Early diagnosis and treatment of eye diseases is essential to prevent visual impairment and improve quality of life.⁶ One way to monitor the quality of healthcare management for patients suffering from eye diseases is to explore the associated rate of hospital admissions. Hospital admission rates are important measures for health-care monitoring and assessment of interventions.¹² Admission rates are mainly influenced by the number of new cases of disease, and it is an important measure of healthcare quality.^12,13 Thus, this study aims to investigate the trends of hospital admissions concerning diseases of the eye and adnexa in the UK in the last two decades.

Materials and Methods

Study Sources and the Population

This is an ecological study using publicly available data taken from the two main medical databases in England and Wales: the Hospital Episode Statistics (HES) database in England¹⁴ and the Patient Episode Database for Wales (PEDW).¹⁵ These two medical databases have been used previously to explore the trends of different health outcomes and the associated hospital admissions.^16–21

Hospital admission data were collected for the period between April 1999 and March 2019.^14,15 The HES and PEDW databases contain hospital admission data for all diseases of the eye and adnexa for patients from all age categories, reported as follows: below 15 years, 15–59 years, 60–74 years, and 75 years and above. We identified hospital admissions related to diseases of the eye and adnexa using the tenth version of the International Statistical Classification of Diseases (ICD-10) system. All diagnostic codes for diseases of the eye and adnexa (H00 – H59) were used to identify all hospital admissions related to various types of diseases of the eye and adnexa in England and Wales. The World Health Organization (WHO) developed a medical classification for diseases of the eye and adnexa known as the International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) Code range (H00-H59). It includes ICD-10 codes for eyelid, orbit, and lacrimal systems disorders (H00-H05), conjunctival disorders (H10-H11), corneal, scleral, ciliary body, and iris disorders (H15-H22), lenticular disorders (H25-H28), retinal and choroid disorders (H30-H36), glaucoma (H40-H42), vitreous body and globe disorders (H43-H44), optic nerve and visual pathway disorders (H46-H47), ocular muscles, binocular movement, refraction, and accommodation disorders (H49-H52), blindness and visual disturbances (H53-H54), other eye and adnexal disorders (H55-H57), and intra- and postoperative complications (H59-H59).²²

HES and PEDW databases record all hospital admissions, outpatients and accident and emergency (A&E) activities performed at all National Health Service (NHS) trusts and any independent sector funded by NHS trusts. Data for hospital admissions in England and Wales are available from the years 1999/2000 onwards. Available data include patient demographics, clinical diagnoses, procedures, and duration of stay. HES and PEDW data are checked regularly to ensure their validity and accuracy.^14,23 To calculate the annual hospital admission rate for diseases of the eye and adnexa, we collected mid-year population data for the period between 1999 and 2019 from the Office for National Statistics (ONS).³

Ethical Approval

Hospital admissions, mortality, and population data are publicly available as anonymised data. Therefore, there was no need to obtain ethical approval for the study.

Statistical Analysis

Annual hospital admission rates related to diseases of the eye and adnexa with 95% confidence intervals (CIs) were calculated using the number of hospital admissions related to each type of disease of the eye and adnexa for each age group divided by the mid-year population of the same age group of the same year. The trend in hospital admissions was assessed using a Poisson model. All analyses were performed using SPSS version 27 (IBM Corp, Armonk, NY, USA).

Results

A total of 11,691,873 hospital admission episodes related to diseases of the eye and adnexa were reported in England and Wales during the study period between 1999 and 2019. Females contributed to 56.9% of the total number of hospital admissions, accounting for 6,663,566 hospital admission episodes with an average of 333,178 admissions per year. Hospital admission rate among males increased by 91.2% [from 6.19 (95% CI 6.16–6.22) in 1999 to 11.83 (95% CI 11.80–11.87) in 2019 per 1000 persons]. Hospital admission rate among females increased less sharply by 63.2% [from 8.71 (95% CI 8.68–8.75) in 1999 to 14.22 (95% CI 14.18–14.26) in 2019 per 1000 persons].

The total annual number of hospital admissions for diseases of the eye and adnexa for various reasons rose from 389,889 in 1999 to 772,452 in 2019, representing an increase in hospital admission rate of 73.8% [from 7.48 (95% CI 7.45–7.50) in 1999 to 13.00 (95% CI 12.97–13.02 in 2019 per 1000 persons, trend test, p < 0.01).

The most common cause of hospitalisations for diseases of the eye and adnexa were disorders of the lens (62.3%), followed by disorders of the choroid and retina (14.2%), followed by disorders of the eyelid, lacrimal system and orbit (11.5%) (Table 1).

Table 1 Percentage of Hospital Admissions from Total Number of Admissions per ICD Code During the Study Period

ICD Code	Description	Percentage from Total Number of Admissions
H00–H05	Disorders of eyelid, lacrimal system and orbit	11.5%
H10–H11	Disorders of conjunctiva	1.0%
H15–H22	Disorders of sclera, cornea, iris and ciliary body	1.9%
H25–H28	Disorders of the lens	62.3%
H30–H36	Disorders of choroid and retina	14.2%
H40–H42	Glaucoma	3.3%
H43–H44	Disorders of vitreous body and globe	1.0%
H46–H47	Disorders of optic nerve and visual pathways	0.4%
H49–H52	Disorders of ocular muscles, binocular movement, accommodation and refraction	2.7%
H53–H54	Visual disturbances and blindness	1.2%
H55–H57	Other disorders of eye and adnexa	0.4%
H59–H59	Intraoperative and post procedural complications and disorders of eye and adnexa, not elsewhere classified	0.3%

During the past two decades, the highest increase in rate of hospital admissions was observed in disorders of the choroid and retina, followed by disorders of the optic nerve and visual pathways, followed by visual disturbances and blindness at 3.6-fold, 1.9-fold, and 1.2-fold, respectively. On the other hand, the rate of hospital admissions due to disorders of the eyelid, lacrimal system and orbit, and disorders of ocular muscles, binocular movement, accommodation and refraction decreased by 7.7% and 4.1%, respectively (Figure 1), Table 2.

Table 2 Percentage Change in the Hospital Admission Rates for Diseases of the Eye and Adnexa

Diseases	Rate of Diseases in 1999 per 100,000 Persons (95% CI)	Rate of Diseases in 2019 per 100,000 Persons (95% CI)	Percentage Change from 1999–2019
Disorders of eyelid, lacrimal system and orbit	112.29 (111.38–113.19)	103.69 (102.88–104.51)	−7.7%
Disorders of conjunctiva	8.75 (8.50–9.01)	10.74 (10.47–11.00)	22.7%
Disorders of sclera, cornea, iris and ciliary body	17.36 (17.01–17.72)	26.84 (26.42–27.26)	54.6%
Disorders of lens	471.22 (469.37–473.08)	813.25 (810.97–815.53)	72.6%
Disorders of choroid and retina	49.23 (48.63–49.83)	228.82 (227.61–230.04)	364.8%
Glaucoma	33.15 (32.66–33.65)	43.25 (42.72–43.77)	30.4%
Disorders of vitreous body and globe	8.34 (8.09–8.59)	11.80 (11.53–12.08)	41.5%
Disorders of optic nerve and visual pathways	2.32 (2.19–2.45)	6.71 (6.50–6.92)	189.2%
Disorders of ocular muscles, binocular movement, accommodation and refraction	28.98 (28.52–29.45)	27.80 (27.38–28.22)	−4.1%
Visual disturbances and blindness	7.38 (7.15–7.61)	16.58 (16.25–16.91)	124.7%
Other disorders of eye and adnexa	3.76 (3.59–3.93)	5.39 (5.21–5.58)	43.5%
Intraoperative and postprocedural complications and disorders of eye and adnexa, not elsewhere classified	4.98 (4.79–5.17)	4.68 (4.50–4.85)	−6.1%

Figure 1 Hospital admission rates in England and Wales stratified by type between 1999 and 2019.

Considering age group variations in diseases of the eye and adnexa-related hospital admissions, the age group 75 years and above accounted for 49.0% of the total number of hospital admissions related to diseases of the eye and adnexa, followed by the age group 60–74 years with 31.4%, then the age group 15–59 years with 16.2%. The highest increase in rate of hospital admissions related to diseases of the eye and adnexa was for the age group 60–74 years, which increased by 69.7% [from 16.52 (95% CI 16.43–16.62) in 1999 to 28.03 (95% CI 27.92–28.13) in 2019 per 1000 persons]. Hospital admission rate among patients aged 75 years and above increased by 57.0% [from 47.10 (95% CI 46.89–47.31) in 1999 to 73.96 (95% CI 73.73–74.19) in 2019 per 1000 persons]. Hospital admission rate among patients aged 15–59 years increased by 48.4% [from 2.29 (95% CI 2.27–2.31) in 1999 to 3.40 (95% CI 3.38–3.42) in 2019 per 1000 persons]. Hospital admission rate among patients below 15 years increased by 1.4% [from 1.92 (95% CI 1.90–1.95) in 1999 to 1.95 (95% CI 1.92–1.98) in 2019 per 1000 persons] (Figure 2).

Figure 2 Overall rates of hospital admission stratified by age group.

Hospital Admission Rate by Gender

Overall, diseases of the eye and adnexa-related hospital admission rates were higher among females compared to males (Figure 3). The majority of hospital admissions were more common among females, except for disorders of the conjunctiva, disorders of the sclera, cornea, iris and ciliary body, and disorders of the vitreous body and globe, which were more common among males (Figure 4).

Figure 3 Overall rates of hospital admission stratified by gender.

Figure 4 Rates of hospital admission stratified by type and gender.

Hospital Admission Rate by Age Group

The majority of hospital admissions were found to be higher in older age groups, except for disorders of the optic nerve and visual pathways, and disorders of ocular muscles, binocular movement, accommodation and refraction, which were more prevalent among the younger age groups (Figure 5).

Figure 5 Rates of hospital admission stratified by type and age.

Hospital Admission Stratified by Type of Admission

Around half the reported number of admissions for diseases of the eye and adnexa was “regular admission that involved inpatients treatment” (Figure 6). The total annual rate for diseases of the eye and adnexa admission, emergency admission, waiting list, and day case increased by 72.4%, 16.0%, 63.0%, and 1.23-fold, respectively (Figure 7). The total annual number for diseases of the eye and adnexa admission, emergency admission, waiting list, and day case increased by 96.5%, 32.3%, 85.8%, and 1.55-fold, respectively (Table 3).

Table 3 Hospital Admission Numbers for Diseases of the Eye and Adnexa Stratified by Type of Admission

	Total Number of Reported Admissions			Type of Admission									Day Case (Elective Inpatients Who Have Been Admitted for Treatment Just for the Day)
				Admission (Involving Inpatient Treatment)			Emergency Admission			Waiting List (Indicating Elective Admission Method)
	England and Wales	England	Wales	England and Wales	England	Wales	England and Wales	England	Wales	England and Wales	England	Wales	England and Wales	England	Wales
1999/2000	757,707	713,664	44,043	388,141	362,378	25,763	25,368	23,926	1442	344,198	327,360	16,838	282,060	265,475	16,585
2000/2001	805,055	751,233	53,822	417,696	386,577	31,119	23,836	22,489	1347	363,523	342,167	21,356	321,195	298,274	22,921
2001/2002	815,994	759,332	56,662	427,600	394,655	32,945	23,609	22,310	1299	364,785	342,367	22,418	340,695	315,219	25,476
2002/2003	845,524	795,743	49,781	444,484	416,937	27,547	23,298	21,972	1326	377,742	356,834	20,908	364,654	342,721	21,933
2003/2004	895,586	847,601	47,985	472,925	446,070	26,855	24,599	23,321	1278	398,062	378,210	19,852	396,153	373,873	22,280
2004/2005	901,470	854,670	46,800	478,250	452,414	25,836	26,510	25,269	1241	396,710	376,987	19,723	405,661	383,933	21,728
2005/2006	899,285	847,703	51,582	477,780	450,149	27,631	28,447	27,158	1289	393,058	370,396	22,662	406,214	382,160	24,054
2006/2007	905,075	850,899	54,176	482,534	453,417	29,117	25,449	24,160	1289	397,092	373,322	23,770	418,544	392,757	25,787
2007/2008	988,620	932,838	55,782	532,128	501,582	30,546	26,060	24,698	1362	430,432	406,558	23,874	471,524	444,229	27,295
2008/2009	1,102,204	1,037,140	65,064	582,706	549,528	33,178	27,294	25,926	1368	492,204	461,686	30,518	524,000	493,910	30,090
2009/2010	1,159,512	1,095,902	63,610	609,185	576,661	32,524	27,041	25,661	1380	523,286	493,580	29,706	553,335	523,831	29,504
2010/2011	1,178,099	1,115,268	62,831	619,816	587,598	32,218	26,705	25,236	1469	531,578	502,434	29,144	568,465	539,187	29,278
2011/2012	1,169,583	1,105,866	63,717	615,278	583,131	32,147	25,000	23,642	1358	529,305	499,093	30,212	568,519	538,972	29,547
2012/2013	1,216,695	1,154,261	62,434	638,663	607,134	31,529	26,612	25,133	1479	551,420	521,994	29,426	592,246	563,464	28,782
2013/2014	1,302,132	1,234,849	67,283	682,536	648,510	34,026	27,091	25,515	1576	592,505	560,824	31,681	630,597	599,604	30,993
2014/2015	1,406,062	1,338,079	67,983	739,216	704,913	34,303	28,481	26,732	1749	638,365	606,434	31,931	687,430	656,244	31,186
2015/2016	1,411,300	1,340,125	71,175	749,221	713,287	35,934	29,327	27,534	1793	632,752	599,304	33,448	703,666	670,871	32,795
2016/2017	1,426,645	1,351,746	74,899	749,659	711,723	37,936	30,551	28,689	1862	646,435	611,334	35,101	701,324	666,676	34,648
2017/2018	1,383,807	1,307,710	76,097	726,697	688,212	38,485	31,797	30,061	1736	625,313	589,437	35,876	682,692	647,403	35,289
2018/2019	1,435,924	1,353,430	82,494	762,707	720,870	41,837	33,556	31,628	1928	639,661	600,932	38,729	718,249	679,937	38,312
% Change	89.5%	89.6%	87.3%	96.5%	98.9%	62.4%	32.3%	32.2%	33.7%	85.8%	83.6%	130.0%	154.6%	156.1%	131.0%

Figure 6 Percentage of each admission type for diseases of the eye and adnexa from total number of reported admissions per year.

Figure 7 Hospital admission rates due to diseases of the eye and adnexa in stratified by admission type between 1999 and 2019.

Discussion

To the best of our knowledge, this is the first study that has investigated the trends of hospital admissions concerning the diseases of the eye and adnexa in the UK in the last two decades. The current study found a significant increase in the rate of hospital admissions related to diseases of the eye and adnexa in England and Wales; an increase in hospital admission rate by 73.8%, with an average increase of 3.7% per year during the past two decades. This significant increase in hospital admission rate can be attributed to the increased population resulting from improved life expectancy in both sexes and high average annual migration rates (approximately 0.67% per year from 2005 to 2020).²⁴ In addition, the increasing awareness among the UK population of eye health problems, the availability of advanced diagnostic methods, and the existence of screening programmes play an important role in increasing the rate of hospital admissions.^25–27

For example, the number of all hospital admissions in England was 16.2 million between 2015 and 2016, increasing by 30% from 12.7 million ten years before. The Hospital Admitted Patient Care Activity, 2015–16 report revealed that the largest number of hospital admissions (around 1.3 million admissions between 2015 and 2016) was observed in people aged 65 to 69. The average age of hospitalised patients has also been rising steadily over the last years. The number of admissions increased slightly from 5.8 million to 6.3 million from 2005 to 2016, less than 9%, in patients aged 44 and under, while it increased significantly from 6.9 million to 9.9 million by nearly 44% in patients aged 45 and above. Over the same period, the population grew by 8%, at a much lower rate than the hospital admission rate (30%). Hospital admissions that needed interventions increased by 56%, from 6.8 million to 10.6 million between 2005 and 2016.²⁸

In the UK, the number of females has been greater than the number of males over the last 70 years (in 2020, the estimated population by gender was approximately 34 million females and 33 million males). Life expectancy was also higher in females than males between 1981 and 2019 with low levels of improvement in life expectancy in males at limited periods. For example, from 2017 to 2019, life expectancy at birth was 79.4 and 83.1 years for males and females, respectively. At age 65 years, life expectancy was 18.8 and 21.1 years for males and females, respectively. The larger female population and the higher life expectancy in females put women at greater risk for age-related diseases than males.²⁴ These demographic statistics explain the higher percentage (56.9%) of total number of hospital admissions among females over the last two decades in England and Wales.

Our study revealed a 91.2% and 63.2% increase in the hospital admission rate among males and females in England and Wales in the last two decades, respectively. The higher increase in hospital admission rate among males can be attributed to the increased male to female ratio (the number of male births per one female birth) from 92.61 to 97.67 males per 100 females from 1950 to 2020, with an average annual increase of 0.38%.³ Increased life expectancy among males has also contributed to this high rate.

The most common causes of hospital admissions for diseases of the eye and adnexa were lens disorders (62.3%), followed by choroid and retina disorders (14.2%), and eyelid, lacrimal system, and orbit disorders (11.5%). This is related to the increasing number of people who have developed these diseases over the last decade in the UK. According to the Royal National Institute of Blind People (RNIB), in the UK, about 33,462,473, 25,332,332, and 54,876,508 people were at risk of having cataract, age-related macular degeneration (AMD) (early AMD, intermediate AMD, dry AMD, and wet AMD), and diabetic retinopathy (DRP) (background DRP, non-proliferative DRP, proliferative DRP, and diabetic maculopathy) in 2020, respectively. The estimated number of people who will experience partial sight loss and blindness due to cataracts is expected to reach 248,504 and 32,750 in 2020, respectively. The yearly cataract surgery load is expected to reach 473,944 in 2020.²⁹ The estimated number of people who will have wet AMD is expected to reach 515,509 in 2020, up from 414,561 in 2010.²⁹ In England and Wales, where AMD is the leading cause of visual impairment,³⁰ the estimated number of people who will have wet AMD is expected to reach 458,617, representing 89% of the total number of expected cases in the UK.²⁹

By 2020 in the UK, it is expected that there will be more people who have background DRP (from 748,209 people in 2010 to 938,448 by 2020 (833,410 in England and Wales)) and diabetic maculopathy (from 187,842 in 2010 to 235,602 by 2020 (209,232 in England and Wales)) than previously.²⁹ Disorders of the eyelid, lacrimal system and orbit are common in the UK population. This can be attributed to the aging population, who are more susceptible to senile ptosis, lacrimal, and orbital disorders. Thyroid eye disease (TED), which is the most common cause of proptosis and orbital inflammation in adults worldwide,³¹ also occurs frequently in the UK (about 300,000 people in the UK have TED).³²

In this study, we found that the highest increase in hospital admission rate was due to disorders of the choroid and retina. This can be correlated to the increased number of admissions due to surgically treated retinal diseases such as retinal detachment. In 2018, Madi and Keller found that the hospital admission frequency due to retinal detachment was increased significantly between 2000 and 2018, particularly for rhegmatogenous retinal detachment. They attributed this to the increased rates of cataract surgeries, myopia, recurrent retinal detachment, and increased longevity, which increased disease incidence among the UK population.³³ The high incidence of DRP and wet AMD in the UK might affect the hospital admission rate in our study. Vitreoretinal surgeries for managing the complications of DRP, such as vitreous hemorrhage and tractional retinal detachment, could contribute significantly to this increase. Patients with DRP, wet AMD, or other retinal vascular diseases treated with intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) drugs receive their therapy mainly at outpatient clinics (clean rooms) or, sometimes, at operating rooms. Thus, this might not realistically reflect the participation of these conditions in increasing the hospital admission rate despite the significant increase in the number of injections used in the last decade. Bevacizumab, ranibizumab, and aflibercept are anti-VGEF drugs used for DRP and wet AMD treatment. In some patients, laser and photodynamic therapies can be used with anti-VGEF treatment.^34–36 A study carried out at Moorfields Eye Hospital, a large tertiary referral centre in the UK, found that the number of intravitreal injections had increased about 11-fold between 2009 and 2019. A total of 44,924 injections were given in 2019, of which 87% were Aflibercept. The majority of injections were delivered for wet AMD treatment.³⁷ The second-highest rate was observed in disorders of the optic nerve and visual pathways, which can be linked to the aging population in the UK, who are more prone to stroke and optic nerve diseases, such as anterior ischemic optic neuropathy and giant cell arteritis.^38–40

Gender and age were significant factors that contributed to the increased hospital admission rate due to specific types of diseases of the eye and adnexa. Marked fluctuations in females’ hormones during menstruation, pregnancy, and menopause can protect, induce, or exaggerate many ocular conditions. This hormonal effect is related to the presence of sex hormone receptors in the eyes. For example, uveitis symptoms were found to be exacerbated by menstruation and stabilised during pregnancy, and oestrogen was found to expose women to a higher risk for progression of diabetic retinopathy.⁴¹ Androgens in males also affect the eye and may be the cause of increasing prevalence of some ocular disorders in men.⁴²

We found that the admission rate for some disorders was higher among females, including lens disorders, choroidal and retinal disorders, optic nerve and visual pathways disorders, eyelid, orbit, and lacrimal systems disorders, and visual disturbance and blindness. Female gender is considered a risk factor for many ocular diseases, such as cataracts, glaucoma, wet AMD, DRP, optic neuritis, thyroid eye disease, and autoimmune diseases.^1,41–43 In both developed and developing countries, two out of three blind people are women.⁴² Concerning age, we found that the rate of admissions for disorders of ocular muscles, binocular movement, accommodation and refraction was significantly higher among people aged below 15 (children and teenagers) since these disorders are more frequent among this age group.

All types of admissions increased during the past two decades for diseases of the eye and adnexa whether regular admissions, emergency admissions or waiting list admissions. This indicates a better health-care system and early detection and diagnosis of diseases in the clinical practice. However, the rise in emergency admission is also related to the progression of the disease, and may reflect the severity of the disease which require frequent hospitalisation and diagnostic or therapeutic interventions.

To the best of our knowledge, this is the first study to explore trends in the rates of hospital admission due to diseases of the eye and adnexa worldwide and in England and Wales specifically without restricting the study to specific inclusion/exclusion criteria. The study was a population study at the national level. Our study provided detailed hospital admission rate for all diseases of the eye and adnexa stratified by age and gender giving a clear imagination about the hospitalisation profile for this group of patients for a period of 20 years. This study has some limitations. First, for each ICD-10 code range, we were unable to specifically identify which eye problems had the greatest impact on the hospital admission rate. Second, due to the nature of data provided by these databases we were unable to access data on the patient level to identify other risk factors associated with eye problems, such as the presence of comorbidities (such as diabetes mellitus) or other factors associated with eye problems. The reported hospital admission data in this study include emergency and elective admission, therefore, findings should be interpreted carefully as this might have led to overestimation of the presented admission rate. Another limitation is the impact of time-trend analysis on the study findings, as with the changing in indication for hospital admission (such as increasing trend of one day surgery), the proportion of some ocular disorders might not reflect the real intervention that had been performed.

Conclusion

Hospital admissions related to eye and adnexa disorders are common in the UK. There are clear gender and age roles in the epidemiology of hospital admissions related to eye and adnexa disorders. Further observational studies are warranted to identify other risk factors for these important causes of hospitalisation.

Data Sharing Statement

Publicly available datasets were analyzed in this study. This data can be found here: http://http//content.digital.nhs.uk/hes, http://www.infoandstats.wales.nhs.uk/page.cfm?pid=41010&orgid=869.

Ethics Approval and Informed Consent

The research ethics committee of the Faculty of Pharmacy at Isra University approved the study protocol (SREC/21/11/014). Hospital admissions, mortality, and population data are publicly available as de-identified data. Therefore, it was considered an exempt category.

Disclosure

The authors declare no conflicts of interest in this work.