Spontaneous uterine rupture in the 35th week of gestation after laparoscopic adenomyomectomy

Abstract

Uterine rupture rarely occurs during pregnancy, but it is a critical situation if so. It is already known that a history of uterine surgeries, such as cesarean section or myomectomy, is a risk factor for uterine rupture. Currently, the laparoscopic adenomyomectomy is a widely performed procedure, but associated risks have not been defined. We observed a case of spontaneous uterine rupture in a patient during the 35th week of gestation, after a laparoscopic adenomyomectomy. A 42-year-old, gravida 2, para 0 woman became pregnant after a laparoscopic adenomyomectomy and her pregnancy was conventional. At a scheduled date in the 35th week of gestation, after combined spinal epidural anesthesia and frequent uterine contractions, a weak pain suddenly ensued. After 13 minutes of uterine contractions, vaginal bleeding was evident. A cesarean section was performed, and the uterine rupture was found in the scar. After a laparoscopic adenomyomectomy, a pregnant uterus can easily rupture by rather weak and short uterine contractions, and is characterized by vaginal bleeding. When uterine bleeding is observed in pregnant women that have a history of adenomyomectomy, one should consider uterine rupture.

Keywords:

• uterine rupture
• pregnancy
• laparoscopic adenomyomectomy
• uterine contraction
• vaginal bleeding

Introduction

Uterine rupture rarely occurs during pregnancy, but it is a critical obstetric complication associated with maternal and fetal mortality and morbidity.¹ It is known that the rate of uterine rupture increases in patients with a history of uterine surgery, such as cesarean section or myomectomy. Laparoscopic adenomyomectomies are widely performed to treat infertility or palliate symptoms of menstruation. It is however, not yet known what kinds of complications this procedure can cause in pregnant women. Here we report a case of spontaneous uterine rupture in the 35th week of gestation after a laparoscopic adenomyomectomy.

Case report

A 42-year-old, gravida 2, para 0 woman was referred to our hospital at the 11th week of gestation. Before she got pregnant, she had had sterility treatment, but it hadn’t been successful. She subsequently received a laparoscopic adenomyomectomy in another hospital 14 months before referral. The findings in the operation were as follows: The lesion of adenomyosis existed at the posterior wall of the uterus and the lesion and rectum adhered to each other firmly. A vertical incision was made in the middle of the posterior wall of the uterus, and the adenomyosis lesion was enucleated as much as possible (50 g in total). Finally, the uterine wall was repaired with a three-layer suture. One year after the operation, she conceived spontaneously.

The patient’s singleton pregnancy was uneventful and she was admitted at the 30th week of gestation for the purpose of bed rest. This was done because past reports suggest that uterine rupture after laparoscopic adenomyomectomy typically occurs around the 30th week of gestation. The patient’s hospital stay was incident-free, and a cesarean section was due to be performed at the 34th week of gestation to achieve optimal trade-off between fetal lung maturation and fetal prematurity. However, the patient’s cesarean section was moved to the 35th week of gestation due to her strong request. On the scheduled date, no notable events occurred until the patient went into the operating room. The patient had undergone combined spinal epidural anesthesia, and was experiencing frequent uterine contractions when a weak pain suddenly occurred. After 13 minutes of uterine contractions, vaginal bleeding was observed while sterilizing the vagina. Cesarean section was performed immediately and a female neonate, weighing 2,283 g, was delivered 31 minutes after uterine contractions had begun. The neonate’s Apgar scores were 7 and 8 at 1 and 5 minutes, respectively. Umbilical arterial gas analysis indicated no acidosis (pH 7.267, base excess −3.4).

The rectum and omentum adhered to the posterior uterine wall, where there was a scar from the previous adenomyomectomy. Bleeding was found in the adhered tissue and therefore we peeled off those adhesions. A 1.5 cm hole was found in the uterus (Figure 1). One area did not have a muscle layer and was covered with only uterine serosa adjacent to the ruptured area. This was repaired with a three-layer suture and total sutured length was 7–8 cm. The patient’s postoperative process proceeded without complications and the patient was discharged at a postoperative date of 12 days. Informed consent was obtained from the patient orally, in order to retain the anonymity of the patient. No ethics approval was required for this study.

Figure 1 Uterine rupture with a 1.5 cm hole.

Note: One area did not have a muscle layer and was covered with only uterine serosa adjacent to the ruptured area.

Discussion

Two important clinical issues were identified: 1) after a laparoscopic adenomyomectomy, a pregnant uterus might rupture easily by rather weak and short uterine contractions; 2) uterine contractions followed by uterine bleeding might be useful for the diagnosis of uterine rupture.

First, after laparoscopic adenomyomectomy, a pregnant uterus might rupture easily by rather weak and short uterine contractions. A recent review by Morimatsu et al showed that the rate of uterine rupture after adenomyomectomy during pregnancy is 6.0%² in contrast to the entire rate of uterine rupture during pregnancy, which is 0.035%.³ This is much higher than the rate of complications after cesarean section (0.27%–0.7%)^4,5 or myomectomy (2.45%).^6,7 We determined some reasons why uterine rupture frequently occurs in pregnant women with prior laparoscopic adenomyomectomies. The boundary between the normal uterine muscle layer and the lesion is unclear. A lesion of adenomyosis tends to remain around the edges of excisions and the area to be sutured, which might lead to weak connections between sutured edges. If a lesion of adenomyosis is enucleated widely to eliminate the lesion, the uterus will be small and irregular in shape, which leads to a diminished capacity to expand.⁸ With a laparoscopic adenomyomectomy, it is particularly difficult to delineate the border of the lesion because of a lacking sense of touch and deep sensation.⁹

Only five publications have presented cases of uterine rupture during pregnancy in patients with prior histories of adenomyomectomy (laparoscopic 4, laparotomic 1) (Table 1).^2,8,10,11 According to 96 reported cases (Table 2),^2,8–16 the rate of uterine rupture during pregnancy was 6.25%; this is similar to the review reported by Morimatsu et al.² It would appear that the frequency of uterine rupture after laparoscopic adenomyomectomy is higher than that of laparotomic adenomyomectomy (Tables 1 and 2), but there is no cohort study to compare these so far.

Table 1 Characteristics in five cases of uterine rupture during pregnancy after adenomyomectomy

Author (year)	Age (years)	Operative method	Contraception period (months)	Gravida (G), para (P)	GA (weeks)	Uterine contraction or abdominal pain	Uterine bleeding	Outcome	Delivery method
Suginami (2001)^Citation10	NA	Laparoscopic	NA (>3)	NA	32	NA	NA	Live birth	Emergency cesarean section
Wada et al (2006)^Citation11	33	Laparoscopic	12	G0P0	30	+	−	Live birth	Emergency cesarean section
Morimatsu et al (2007)^Citation2	35	Laparoscopic	1	G1P1	28	+	−	Live birth	Emergency cesarean section
Onishi et al (2011)^Citation8	40	Laparotomic	NA	G3P1	31	+	−	Live birth	Emergency cesarean section
Our case (2014)	42	Laparoscopic	11	G2P0	35	+	+	Live birth	Elective cesarean section

Notes: +, present; −, absent.

Abbreviations: GA, gestational age; NA, not available.

Table 2 Pregnancy outcome in patients with prior history of adenomyomectomy

Author (year)	Number of cases	Abortion or still birth	Live birth	Uterine rupture	Operative method
suginami (2001)^Citation10	17	1	16	1	Laparoscopic
Matsuura et al (2004)^Citation12	11	4	7	0	Laparotomic
Fujishita (2006)^Citation13	5	3	2	0	Laparotomic
Wada et al (2006)^Citation11	18	1	17	2 (abortion 1, live birth 1)	Laparoscopic
takeuchi et al (2006)^Citation14	1	0	1	0	Laparoscopic
Morimatsu et al (2007)^Citation2	1	0	1	1	Laparoscopic
ota et al (2009)^Citation9	4	0	4	0	Laparoscopic
onishi et al (2011)^Citation8	1	0	1	1	Laparotomic
osada et al (2011)^Citation15	16	2	14	0	Laparotomic
saremi et al (2014)^Citation16	21	5	16	0	Laparoscopic
our case (2014)	1	0	1	1	Laparoscopic

Uterine rupture or dehiscence during pregnancy tends to occur more frequently after laparoscopic myomectomy than after laparotomic myomectomy. Specifically, the frequency of uterine dehiscence is 1.85–4.94% in laparoscopic^6,7 and 0% in laparotomic (this finding is extremely limited because it depends on only 69 cases from two reports).^6,7 We guess that uterine rupture or dehiscence is similarly more common in laparoscopic than in laparotomic adenomyomectomy cases.

Second, uterine contractions followed by uterine bleeding might be useful for the diagnosis of uterine rupture. Uterine rupture does not have any typical symptoms and is often asymptomatic.^17,18 Classical symptoms and signs are abdominal pain, external bleeding, vital signs indicating shock, disappearance of labor pain, and signs of fetal distress etc. In this case, the patient experienced both abdominal pain and external bleeding.

Conclusion

A pregnant uterus after laparoscopic adenomyomectomy might rupture easily by rather weak and short uterine contractions. Furthermore, uterine contractions followed by uterine bleeding might be useful for the diagnosis of uterine rupture. When uterine contractions are followed by uterine bleeding in pregnant women that have had a prior adenomyomectomy, this must be considered a potential sign of uterine rupture. If physicians are planning to perform surgery for treating sterility and infertility, they should carefully choose the modality of surgery and get more detailed informed consent from patients with adenomyosis. Further reports should be accumulated to develop more reliable and safe operative techniques, and to establish guidelines for pregnancy after adenomyomectomy in women of reproductive age.

Disclosure

The authors report no conflicts of interest in this work.