A randomized controlled trial of preprocedure administration of parecoxib for therapeutic endoscopic retrograde cholangiopancreatography

Abstract

Introduction

Parecoxib is occasionally used for analgesia in postprocedural patients. The clinical efficacy of parecoxib used for endoscopic retrograde cholangiopancreatography (ERCP) is controversial. The aim of the study was to determine the clinical efficacy of preprocedure administration of parecoxib for therapeutic ERCP patients.

Methods

Eighty-five patients who underwent therapeutic ERCP in a single year were randomly assigned to normal saline group (C, n = 43) and parecoxib group (P, n = 42). Patients in group C received normal saline and those in group P received 40 mg of parecoxib intravenously in equivalent volume. Patients in both groups received the saline or parecoxib 60 seconds before administration of the sedative agents. All patients were monitored for the depth of sedation by using the Narcotrend^TM monitor, maintaining stage D0–E0 during ERCP. All patients were oxygenated with 100% O₂ via nasal cannula and sedated with 0.03 mg/kg of intravenous midazolam and 1 μg/kg of intravenous fentanyl as well as the titration of intravenous propofol. After the ERCP procedure, pethidine in an intramuscular dose of 0.5–1.0 mg/kg was used as rescue medication. The pain scores (visual analog scale [VAS], 0–10) at 2, 12, and 24 hours post-ERCP, the total number of doses of pethidine used, the dose volume of pethidine used, patient satisfaction, endoscopist satisfaction, and complications were recorded.

Results

There were no significant differences in sedative and analgesic agents used during the procedure, pain at 24 hours post-ERCP, endoscopist satisfaction, and complications in both groups. The total number of doses of pethidine used post-ERCP in group C was significantly higher than in group P. Additionally, the mean pain score at 2 and 12 hours post-ERCP in group C was significantly greater than in group P. Patient satisfaction in group P was higher than in group C.

Conclusion

Preprocedure administration of parecoxib for therapeutic ERCP patients was clinically effective. The analgesic efficacy of a standard dose of parecoxib was clearly demonstrated during the first 12 hours postprocedure. Additionally, patient satisfaction in the parecoxib group was also higher than in the control group.

Keywords:

• parecoxib
• endoscopic retrograde cholangiopancreatography
• clinical efficacy
• preprocedure

Introduction

Postprocedural pain is predictable and prevention of this pain is a better management strategy than treating the pain once it has occurred.¹ Endoscopic retrograde cholangiopancreatography (ERCP) is an invasive procedure and produces moderate-to-severe pain.² It is commonly used for diagnosis and treatment of pancreatobiliary abnormalities.^3,4 Postoperative pain may affect recovery including hospital stay, feeding, and delay in starting work. Therefore, the administration of pain medication would be necessary.

Opioids, local anesthetics, and nonsteroidal anti-inflammatory drugs (NSAID) can be used to manage moderate-to-severe acute pain.⁵ Conventional NSAIDs inhibit the cyclooxygenase (COX) enzymes and, therefore, produce an anti-inflammatory and analgesic effect. The COX-1 isoenzyme plays a key role in the physiological prostaglandin synthesis in the gastric mucosa, platelets, and kidney.⁶ Cox-2 induction has been shown to be associated with pathophysiological stimuli, specifically injury and inflammation. Coxibs are the newer NSAIDs, which specifically inhibit the COX-2 isoenzyme to provide the anti-inflammatory and analgesic effects.⁷ Parecoxib is an injectable prodrug of valdecoxib, which is a potent and selective inhibitor of COX-2.⁸ The analgesic efficacy of parecoxib has been demonstrated after third molar extraction,⁸ gynecological,^8,9 and orthopedic surgeries.^8,10

Currently there have been no reports on the efficacy of parecoxib after the ERCP procedure. This is the first study evaluating the postprocedure analgesic efficacy of a single dose of parecoxib administered prior to the ERCP procedure. The aim of this study was to determine the clinical efficacy of preprocedure administration of parecoxib for therapeutic ERCP patients. The study was designed to test the null hypothesis that procedural pain after the therapeutic ERCP procedure in the parecoxib group would be lower than the placebo group.

Methods

Patients

A total of 85 consecutive patients from a tertiary care teaching hospital in Thailand were recruited for the study. These patients were 18–90 years of age and underwent therapeutic ERCP procedures. Exclusion criteria included any clinical evidence of severe liver diseases according to the American Society of Anesthesiologists (ASA) physical status of classes IV or V. The study was approved by the Institutional Review Board of the Faculty of Medicine, Siriraj Hospital. All the enrolled patients provided written informed consent to undergo the procedures and to participate in the study.

Study design

The study was a single-dose, randomized, blind, and placebo-controlled clinical trial. Eighty-five patients who underwent therapeutic ERCP in a single year, were randomly assigned to either the parecoxib group (P; n = 42) or the normal saline group (C; n = 43). In group P, a 40 mg dose of parecoxib (Dynastat; Pfizer Inc, New York, NY) was given intravenously 60 seconds before sedative agents were administered. In group C, an equivalent volume of normal saline was given intravenously 60 seconds before sedative agents were administered. The primary outcome variable of the study was the post-procedural pain after the therapeutic ERCP procedure. The secondary outcome variables were the total number of doses of pethidine used post-ERCP, the dose volume of pethidine used post-ERCP, patient satisfaction, endoscopist satisfaction, and complications during and immediately after procedure. Procedural pain was compared by using a visual analog scale score (VAS; 0–10).

Sedation procedure

All patients were oxygenated with 100% O₂ via nasal cannula and sedated with 0.03 mg/kg of intravenous midazolam and 1 μg/kg of intravenous fentanyl as well as the titration of intravenous propofol. No other medications were administered before the procedure. All sedated patients were sedated to a deep sedation level, in accordance with guidelines of the American Society of Anesthesiologists.¹¹ Each patient’s level of sedation was assessed by the Narcotrend^TM monitor and maintained at D0–E0, which indicates a deep level. If the depth of sedation was too light, a bolus dose of propofol (10–20 mg) was administered until the desired stage of the Narcotrend^TM monitor was reached. After the ERCP procedure, pethidine in an intramuscular dose of 0.5–1.0 mg/kg was used as rescue medication. Sedation was administered by the residents in anesthesiology and the nurse anesthetists under the supervision of a certified anesthesiologist. The anesthetic personnel were blinded to the randomization procedure. Each patient was monitored with noninvasive blood pressure, heart rate, electrocardiogram, oxygen saturation, and Narcotrend^TM monitoring.¹² Patients’ vital signs were monitored and recorded by the blinded nurse anesthetist or anesthesiology resident.

ERCP procedure

The ERCP procedure was done by using an Olympus video duodenoscope (TJF 160 R; Olympus Corporation, Tokyo, Japan). The endoscopists were three staff endoscopists who had experience of more than ten years. The procedure was performed with the patient in either the prone or left lateral position.

Pain assessment

Before administration of any sedative and analgesic drugs, patients rated their pre-procedure pain on a 0–10 mm VAS, where 0 mm is no pain and 10 mm is the worst imaginable pain. After the procedure, patients were moved to the recovery room, where they were monitored for the next 2 hours. The anesthetic personnel that were blinded to the procedure interviewed the patient with a questionnaire evaluating the procedural pain and the patient’s satisfaction at 24 hours postprocedure. The procedural pain at 2, 12, and 24 hours post-ERCP was evaluated by the VAS. Patient satisfaction was categorized as: 1, very satisfied; 2, satisfied; 3, neutral; and 4, unsatisfied.

The complications during and immediately after the procedure were recorded. Changes in hemodynamic variables such as hypertension or hypotension (increase or decrease in blood pressure by 20% from baseline), tachycardia or bradycardia (increase or decrease in heart rate by 20% from baseline), and oxygen desaturation (SpO₂ < 90%) were recorded. In addition, upper airway obstruction and nausea or vomiting was also recorded as a complication.

Endoscopist assessment

The endoscopist carrying out the procedure was blinded to the randomization method. Immediately after the procedure, the endoscopist was asked to rank his/her satisfaction of the procedure. The endoscopist’s satisfaction for the procedure was ranked as follows: 1, very satisfied; 2, satisfied; 3, neutral; and 4, unsatisfied.

Statistical analysis

To detect a difference in the procedural pain after therapeutic ERCP between the two groups, the estimated sample size was 40 patients per arm. The power of the test was 0.8. Additionally, α was set to 0.05 for all comparisons. Results were expressed as mean ± standard deviation (SD) or percentage (%), when appropriate. Comparisons between the two groups were compared by using χ² tests (for categorical variables), χ² tests for trend (for ordinal variables), and two-sample independent t-tests (for continuous variables). The statistical software package SPSS (v 11; SPSS Inc, Chicago, IL) was used to analyze the data. A significance level of 5% was used throughout the study.

Results

Table 1 summarizes the clinical characteristics of all the patients (43 patients in group C and 42 patients in group P). The mean age in group C was 59.3 ± 13.0 years and the mean age in group P was 59.8 ± 16.6 years. There were no significant differences between the two treatment groups with respect to patient age, sex, weight, height, ASA physical status, duration of procedure, indication, and intervention of procedure. All procedures were completed successfully by using the intravenous sedation technique.

Table 1 Characteristics of patients, duration, indications, and interventions of procedure (mean, SD, and percentage)

	Group Ca (n = 43)	Group Pb (n = 42)	P value
Age (years) (mean, SD)	59.3 (13.0)	59.8 (16.6)	0.099
Sex (%)
Male	18 (41.9)	21 (50.0)	0.451
Female	25 (58.1)	21 (50.0)
Weight (kg) (mean, SD)	55.7 (11.5)	56.4 (12.8)	0.296
Height (cm) (mean, SD)	158.0 (8.2)	157.3 (7.7)	0.690
American Society of Anesthesiologists physical status (%)
I	11 (25.6)	12 (28.6)	0.228
II	28 (65.1)	21 (50.0)
III	4 (9.3)	9 (21.4)
Duration of procedure (minutes) (mean, SD)	36.2 (12.3)	29.2 (11.5)	0.089
Indication (%)			0.629
Cholelithiasis	17 (39.5)	21 (50.0)
Hepatobiliary stricture
Malignancy	18 (41.9)	12 (28.6)
Benign	4 (9.3)	3 (7.1)
Others	4 (9.3)	6 (14.3)
Intervention (%)			0.302
Stone removal	11 (25.6)	17 (40.5)
Stent insertion and/or removal	19 (44.2)	14 (33.3)
Explore common bile duct	4 (9.3)	4 (9.5)
Others	9 (20.9)	7 (16.7)

Notes:

a Group C: normal saline;

b group P: parecoxib.

Abbreviation: SD, standard deviation.

Table 2 shows the mean dose of sedative and analgesic drugs used during the procedure and post-procedure in the two groups. The mean total dose and dose/kg body weight of propofol, midazolam, and fentanyl in both groups were not significantly different. However, the total number of doses of pethidine used during postprocedural period in the parecoxib group was significantly lower than in the control group (P = 0.001).

Table 2 Sedative drugs used during procedure (mean, SD, range) and analgesic drug used post-procedure (n (%) and mean, SD, range)

	Group Ca (n = 43)	Group Pb (n = 42)	P value
During procedure
Mean dose of propofol			0.251
Dose/body weight	3.87 (2.12)	3.73 (1.44)
(mg/kg)	0.65–8.33	2.03–9.05
Mean dose of midazolam			0.325
Dose/body weight	0.03 (0.01)	0.03 (0.01)
(mg/kg)	0.01–0.05	0.01–0.06
Mean dose of fentanyl			0.234
Dose/body weight	0.001 (0.000)	0.001 (0.000)
(mg/kg)	0.000–0.002	0.001–0.002
Postprocedure
Pethidine used
Total number of patients (%)	24 (55.8)	9 (21.4)	0.001*
Mean dose of pethidine			0.119
Dose/body weight	1.07 (0.70)	0.96 (0.28)
(mg/kg)	0.35–3.13	0.67–1.53

Notes:

a Group C: normal saline;

b group P: parecoxib;

* considered to be of statistical significance.

Abbreviation: SD, standard deviation.

Table 3 demonstrates the pre- and postprocedural VAS score, patient satisfaction, and endoscopist satisfaction in both groups. There were not significant differences in pre-procedural VAS score, pain at 24 hours post-ERCP, or endoscopist satisfaction between the two groups. However, VAS score at 2 and 12 hours post-ERCP in group C was significantly greater than in group P (P = 0.005 and 0.002, respectively). In addition, patient satisfaction in group P was significantly higher than in group C (P = 0.002).

Table 3 Pre-and postprocedural pain (mean, SD) and patient and endoscopist satisfaction (n, %)

	Group Ca (n = 43)	Group Pb (n = 42)	P value
Preprocedural pain (VAS)	0.79 (0.99)	0.60 (0.89)	0.592
Postprocedural pain (VAS)
2 hours	3.09 (2.68)	0.81 (1.55)	0.005*
12 hours	1.81 (1.72)	0.74 (1.34)	0.002*
24 hours	1.05 (2.01)	0.48 (1.13)	0.362
Patient satisfaction			0.002*
Very satisfied	15 (34.9)	32 (76.2)
Satisfied	20 (46.5)	8 (19.0)
Neutral	7 (16.3)	2 (4.8)
Unsatisfied	1 (2.3)	0
Endoscopist satisfaction			0.953
Very satisfied	16 (37.2)	15 (35.7)
Satisfied	15 (34.9)	16 (38.1)
Neutral	12 (27.9)	11 (26.2)
Unsatisfied	0	0

Notes:

a Group C: normal saline;

b group P: parecoxib;

* considered to be of statistical significance. VAS 0–10 (0 = none and 10 = unbearable).

Abbreviations: SD, standard deviation; VAS, visual analog scale.

Complications during and immediately after ERCP in both groups were not significantly different. However, the incidence of circulatory and respiratory complications in group C was higher than group P. Hypotension was the most common adverse event in the two groups (Table 4).

Table 4 Complications during and immediately after ERCP (n, %)

	Group Ca (n = 43)	Group Pb (n = 42)	P value
Overall	33 (76.7)	25 (59.5)	0.088
Cardiovascular-related	28 (65.1)	21 (50.0)	0.158
Hypotension	24 (55.8)	20 (47.6)	0.450
Bradycardia	3 (7.0)	1 (2.4)	0.317
Arrhythmia	1 (2.3)	0	0.320
Respiratory-related	5 (11.6)	3 (7.1)	0.479
Hypoxia (SpO2 < 90%)	1 (2.3)	0	0.320
Upper airway obstruction	4 (9.3)	3 (7.1)	0.717
Procedure-related	0	1 (2.4)	0.309
Pancreatitis	0	1 (2.4)	0.309

Notes:

a Group C: normal saline;

b group P: parecoxib.

Abbreviation: ERCP, endoscopic retrograde cholangiopancreatography.

Discussion

The present clinical study was designed to evaluate the analgesic efficacy of preprocedural parecoxib on post-therapeutic ERCP pain. Our results demonstrated that preprocedure administration of parecoxib was clinically effective for ERCP patients. Pain during the first 12 hours post-ERCP in the parecoxib group was significantly lower than in the placebo group. In addition, patient satisfaction in the parecoxib group was also significantly higher than in the placebo group. Many previous studies demonstrated the analgesic efficacy of a single dose of parecoxib in the management of acute postoperative pain.^13,14 However, pain is complex and subjective, and attempts to make valid assessments of it have been fraught with difficulties. It is also influenced by numerous intrinsic and extrinsic factors, and the multiple aspects of pain have been assessed in many different ways.

Measurement of pain relies on patient self-report or on the inferences physicians make on the basis of patient behavior. Pain, however, is likely to vary over time and with different activities.¹⁵ The VAS score is widely used in the measurement of pain since it is simple to use and provides a sensitive indication of pain intensity.¹⁶ The differences in score measured at two different times or by two different patients are referenced to categorical responses contrasting the two health states in order to determine clinically meaningful differences.

Acute pain is a normal physiologic response to an adverse thermal, chemical, or mechanical stimulus that may be caused by surgery, trauma, or acute illness.⁵ Postprocedural pain is managed with the use of NSAIDs, opioids, and local anesthetics. Opioid therapy is recommended as the first choice of medication for the management of postprocedural pain but is associated with a number of adverse effects.¹⁷ Conventional NSAIDs have been used in the management of various types of acute and chronic pain. However, the traditional NSAIDs are generally contraindicated in acute traumatic and surgical pain owing to inhibition of platelets and bleeding potential. Systematic reviews suggest that COX-2 inhibitors are an effective treatment for acute postprocedural pain.^18–20

COX-2 inhibitors are well tolerated when used for preoperative pain management. Because platelets do not contain COX-2, all synthesis of thromboxane A2 in the platelet is mediated by COX-1. Parecoxib is the prodrug of valdecoxib, a selective COX-2 inhibitor, developed for parenteral administration. It exerts its analgesic effect through several proposed mechanisms.

The analgesic efficacy of parecoxib in comparison with a placebo demonstrated a greater analgesic effect with parecoxib. This finding is not unexpected because the analgesic effect of the standard dose (40 mg) of parecoxib is understood to be an action. Nonetheless, the data are helpful to some degree in understanding the potency of parecoxib in managing post-ERCP pain. The timing of the use of parecoxib has received considerable attention based on the research models. The impact of constitutively produced central nervous system (CNS) COX-2 on pain perception is also being considered.^21,22 The most critical time to prevent the windup phenomenon of the CNS may be before the COX-2 mediated prostaglandins are produced in the CNS.

Parecoxib was well tolerated in this study. Adverse events were uncommon. Importantly, no evidence of serious adverse events, such as bleeding, was seen with the parecoxib. Additionally, the incidence of adverse events was similar among the two groups. The adverse events in both groups in the present study occurred due to the sedative agents used. For procedure-related complications, the previous studies showed that, acute pancreatitis developed in 1.3% to 24.4% of patients undergoing ERCP.^23,24 Many factors including difficult cannulation, coagulation current used during sphincterotomy, and repeated injections of contrast into the pancreatic duct and sphincter of Oddi dysfunction, possibly increase the risk of post-ERCP pancreatitis. In the present study, the patient-related factors, baseline clinical presentation, severity of disease, and procedural interventions were similar in both groups. There were no signs and symptoms of post-ERCP pancreatitis in group C. Although, one patient in group P developed acute pancreatitis, the mean pain score in this group was not significantly higher than in group C.

The current study did not compare the cost effectiveness between the two groups. Indirectly, the result of the study showed that the total number of doses of rescue medication used after the procedure in group P was lower than in group C. If so, the cost of the rescue medication in group P was also lower.

Our study has several limitations. First, we use VAS score for pain assessment. The large variability around the mean and the discordance of this scale may reflect a problem with the reproducibility or reliability of our results. We are unable to find any published studies of the reproducibility of measurement of acute pain in the ERCP patients. Second, in our practice, we do not routinely measure serum amylase and lipase levels after the procedure. Abdominal pain from post-ERCP pancreatitis can affect the VAS score. However, during postprocedural period, the patients who develop abdominal pain and fever will be investigated for acute pancreatitis. One patient in group P developed acute pancreatitis as confirmed by clinical and laboratory tests. Third, the pain score assessed in this study was limited to pain intensity and pain rescue medication. There seems to be considerable individual variability in post-ERCP pain perception even following standardized procedure.²⁵ The sensitivity to small changes in pain increases the validity of pain measurement, it can be problematic, when using the VAS to compare effectiveness of differences in mean VAS score, to determine when they can be declared statistically significant, even though they may be of little clinical significance to the patient.²⁶ Therefore, to advance studies of the efficacy of preprocedure administration of parecoxib for therapeutic ERCP patients, it is important to identify a minimum clinically significant difference in pain that can be used as a criterion for assessing differences between the parecoxib and the placebo effects. Additionally, the future research of a large population is needed to replicate and compare the findings of this current study. Last, there was a long interval time from the assessment to the interpretation of pain score, and the study was limited to early (24 hours) post-ERCP procedure. Extrapolation of these findings to other time periods will be undertaken for new discoveries.

Conclusion

Preprocedure intravenous administration of a single dose of parecoxib (40 mg) significantly reduced postoperative pain in patients who had undergone an ERCP procedure. The analgesic efficacy of a standard dose of parecoxib was clearly demonstrated during the first 12 hours postprocedure. Additionally, patient satisfaction in the parecoxib group was also higher than in the control group.

Disclosure

The authors report no conflicts of interest in this work.