Lacrimal drainage anomalies in congenital rubella syndrome

Abstract

Purpose

The objective of this study was to ascertain the lacrimal drainage anomalies in a cohort of patients suffering from congenital rubella syndrome (CRS).

Methods

This was a retrospective case series performed in patients with CRS presenting with associated lacrimal drainage anomalies (LDA) over 6 years from 2011 to 2016. All the patients were confirmed as having CRS after clinical and laboratory testing. Data collected include demographics; associated lacrimal, ocular, and systemic anomalies; interventions performed for lacrimal anomalies; and their anatomical and functional outcomes.

Results

Eighty five patients were diagnosed as having CRS during the study period, and of these 23 eyes of 12 patients with associated LDA were included in the study. The prevalence of LDA was 14% in CRS. The mean age at presentation was 15.5 weeks, and all except one had bilateral presentation. Seventeen eyes were diagnosed with simple congenital nasolacrimal duct obstruction (CNLDO) and the remaining six eyes had complex CNLDO with buried probes. Additional lacrimal anomalies noted in the six complex CNLDO cases included punctal agenesis (n=3), atonic sac (n=3), incomplete punctal canalization (n=2), and single canalicular wall hypoplasia (n=1). At a mean follow-up of 12.54 months, anatomical and functional success were noted in 91.3% (21/23 eyes).

Conclusion

Simple CNLDO was the most common of the LDA in CRS. Buried probe was universal among the cases with complex CNLDO. All CRS patients should be screened for lacrimal anomalies to initiate appropriate interventions for successful outcomes.

Keywords:

• rubella
• lacrimal drainage
• CNLDO
• buried probe
• punctal agenesis

Introduction

Congenital rubella syndrome (CRS) is a term applied to the consequences of an in utero transplacental rubella virus infection. It consists of the classical triad of ocular defects, sensorineural hearing loss, and cardiac anomalies.^1–3 The fetus is susceptible to the widespread systemic effects of the virus because of organogenesis and lack of immunity. Ocular abnormalities are common and include congenital cataract, congenital glaucoma, pigmentary retinopathy, microphthalmia, and many others.^3–14 Lacrimal drainage anomalies have sparsely been documented with CRS, and in the form of a nonspecific dacryostenosis, there is reported prevalence of 2%–4% in various studies.^4,6 The current study presents the various forms of lacrimal drainage anomalies (LDA) associated with CRS, their clinical profile, management, and outcomes.

Methods

A retrospective chart review of all CRS patients who presented with associated LDA over 6 years from 2011 to 2016 was performed. The institutional review board and ethics committee of L.V. Prasad Eye Institute approved this study. Written informed consent was obtained from the parents or legal guardians. All the patients were clinically and laboratory confirmed as having CRS and were referred from pediatric institutions for management of ocular abnormalities. Clinical confirmation was based on the World Health Organization surveillance standards, and laboratory confirmation was a positive blood test for rubella-specific IgM antibodies. Data collected include demographics; associated lacrimal, ocular, and systemic anomalies; interventions performed for lacrimal anomalies; and their anatomical and functional outcomes. LDA from the punctum to the nasolacrimal opening in the inferior meatus were assessed. Irrigation and probing were performed under endoscopic guidance. A simple congenital nasolacrimal duct obstruction (CNLDO) was defined as a membranous obstruction at the inferior-most end of the nasolacrimal duct that could be easily overcome without much resistance.¹⁵ CNLDO associated with other lacrimal anomalies or craniofacial or developmental nasolacrimal duct (NLD) defects were grouped as complex.¹⁵ Antibiotic prophylaxis was administered for infants with associated cardiac anomalies before probing. In addition to irrigation and probing, probe exteriorization was performed for buried probes as per standard protocols published,¹⁶ and intubation was performed in two of these cases following thick buried probe exteriorization. Membranotomy, as described earlier,¹⁷ was performed for cases of incomplete punctal canalization. Anatomical success was defined as patency of lacrimal drainage system following probing, and functional success as resolution of epiphora.

Results

A total of 85 patients were diagnosed as having CRS during the study period, and of these 23 eyes of 12 patients with associated LDA were included in the study. All these 12 patients had cardiac anomalies, while sensorineural hearing loss was noted in 4 patients and microcephaly and micrognathia were noted in 2 patients. The prevalence of LDA was 14% among CRS patients in this series. The mean age at presentation was 15.25 weeks (range: 3–48 weeks). Epiphora was the universal complaint, and all except one had a bilateral presentation. 75% (9/12) additionally presented with discharge. None of the patients had any lacrimal intervention in the past. Of the 23 eyes, ocular abnormalities noted include congenital cataract (n=16), salt and pepper retinopathy (n=5), congenital glaucoma (n=2), nystagmus (n=5), and microcornea (n=5). Of the 23 eyes, 17 were diagnosed with simple CNLDO, and the remaining 6 eyes had complex CNLDO with buried probes. Additional lacrimal anomalies noted in the six complex CNLDO cases include punctal agenesis (n=3; upper punctum =2, lower punctum =1), atonic sac (n=3), incomplete punctal canalization (n=2), and single canalicular wall hypoplasia (n=1) (Table 1). All patients underwent irrigation and probing under endoscopic guidance and with antibiotic prophylaxis for infective endocarditis. Two patients with complex CNLDO had thick buried probes and underwent probe exteriorization and intubation. Two cases of incomplete punctal canalization underwent a successful membranotomy followed by probing. At a mean follow-up of 12.54 months (range: 2–45 months), anatomical and functional success were noted in 91.3% (21/23 eyes). Two eyes with complex CNLDO and buried probes failed the probing and intubation and are awaiting a dacryocystorhinostomy.

Table 1 LDA associated with CRS

Lacrimal drainage system anomalies	Number of eyes (n)
Simple CNLDO	17
Complex CNLDO	6
Punctal agenesis	3 (UP-2, LP-1)
Atonic sac	3
Incomplete punctal canalization	2 (1 UP, 1-LP)
Single canalicular wall hypoplasia	1 (upper canaliculus)

Abbreviations: LDA, lacrimal drainage anomalies; CRS, congenital Rubella syndrome; CNLDO, congenital nasolacrimal duct obstruction; UP, upper punctum; LP, lower punctum.

Discussion

This study focused on the analysis of LDA in patients with clinical- and laboratory-proven CRS. Although simple CNLDO was the most common anomaly, buried probe was universal among the complex CNLDO cases. Intervention led to high success rates; however, some complex CNLDO’s remained recalcitrant to irrigation, probing, and intubation and would eventually require a dacryocystorhinostomy.

Lacrimal drainage system starts developing at roughly around 10 weeks of intrauterine life and continues to develop till around the 7th month. Since early or first-trimester infection are associated with robust organogenesis defects, it is possible that the early in utero infections may lead to the kind of abnormalities as seen in this series, eg, punctal agenesis and single canalicular wall hypoplasia. Subsequent late infections may explain the predisposition to various types of CNLDO.

Vijayalakshmi et al¹² studied 87 eyes of 46 infants and found the prevalence of congenital dacryostenosis to be 2.3% (2/87). Givens et al⁶ studied 125 cases of CRS over a 32 year interval and found 2% (3/125) of them to present with unilateral dacryostenosis. Similarly, Geltzer et al⁴ studied 48 eyes with CRS during the 1964–1965 rubella epidemic in United States and found that the prevalence of lacrimal duct obstruction was 4% (2/48), and all of these cases responded well with probing. Roy et al⁵ quoted Lundstrom’s report mentioning significant association of CRS with dacryostenosis, but no further details could be found. It is important to note that none of these studies defined what they meant by dacryostenosis, and most had no information with regard to their management strategies and patient outcomes. The prevalence of lacrimal anomalies in CRS in the current study is much higher (14%) than that reported in the literature, and multiple new lacrimal anomalies are also described. This can be attributed to the wider awareness at a tertiary-care institute and focused efforts to evaluate lacrimal drainage system in all patients with CRS.

Since patients with CRS have cardiac anomalies, all patients in this study were prescribed prophylactic antibiotics before probing to prevent the risk of infective endocarditis. Since probing-induced bacteremia has been demonstrated in cases of acute dacryocystitis but not the routine cases of CNLDO in systemically healthy infants,¹⁸ it is recommended to give prophylaxis to patients at risk of developing infective endocarditis.^19,20

Conclusion

In conclusion, the current study is the first of its kind to provide a comprehensive assessment of LDA in CRS. The study provides useful insights into the wide range of associated LDA and the outcomes of interventions in such cases. There is a need to include lacrimal drainage assessment in all CRS patients while screening for ocular abnormalities.

Disclosure

Mohammad Javed Ali received support from the Alexander von Humboldt Foundation for his research and he also receives royalties from Springer for the textbook “Principles and Practice of Lacrimal Surgery.” The authors report no other conflicts of interest in this work.