Bilateral macular injury from a green laser pointer

Abstract

We report the case of a 13-year-old boy who had a bilateral macular injury after playing with a green laser pointer for a duration of 1 minute. Clinical examination revealed a decrease in visual acuity and macular injury in both eyes, and imaging investigations revealed a bilateral macular lesion due to exposure to the laser pointer. At 3 months’ follow up, visual function had improved but remained partially impaired. This case emphasizes the importance of cautious and appropriate use of laser pointer devices because of the potential vision-threatening hazards induced by mishandling of these devices.

Keywords:

• green laser pointer
• bilateral
• macular injury

Introduction

Lasers produce a beam of light that is coherent, monochromatic, and unidirectional, and can converge most of its radiant power over small areas, even at great distances. Laser pointers are useful ubiquitous devices used in everyday situations, especially in the educational environment. They are also used frequently by children as toys. Their potential to cause retinal damage is a matter of concern, and manufacturers warn against injudicious ocular exposure to laser light. Low-energy green laser pointers are generally considered to be safe devices and their potential to cause retinal damage is questionable. Here we report a case of macular damage caused by a green laser pointer in a teenager, along with a brief review of the literature.

Case report

A 13-year-old boy presented to our clinic complaining of decreased vision in both eyes 1 day after having intentionally gazed directly into the beam of a green laser pointing device (wavelength 532 nm), that had a maximum power rating of 5 mW (US Food and Drug Administration class 3A or IEC class 3R) stated on its labeling. He held the laser 5 cm away from his eyes for an estimated 30–60 seconds. Prior to this incident, the boy had reported no visual complaints. His last ocular examination had revealed visual acuity of 20/20 in both eyes.

Current examination revealed best-corrected visual acuity of 20/50 in the right eye and 20/30 in the left eye. Anterior segments were normal in both eyes. Fundus examination showed bilateral, yellowish, oval-shaped, drusenoid-like lesions with attenuation of the foveal reflex (Figure 1A and B).

Figure 1 (A and B) Fundus photographs showing yellowish, oval-shaped drusenoid-like lesion with attenuation of the foveal reflex in both eyes. (C and D) Red-free fundus photographs showing heterogeneous foveal lesions. (E and F) Fluorescein angiogram showing early foveal hyperfluorescence with late ill-defined leakage in right eye and left eye, respectively. (G and H) Autofluorescence photos showed heterogeneous hyperfluorescence in the macula of both eyes.

Note: A,C,E, and G are right eye; B,D,F, and H are left eye.

Imaging studies were done on presentation to our practice 18 hours after exposure to the laser device. Optical coherence tomography (3D OCT; Topcon, Tokyo, Japan) of both eyes showed disruption of the outer retinal layer with nonspecific retinal thickening (Figure 2A and B); red-free photographs demonstrated hypopigmented foveal dots bilaterally (Figure 1C and D); fluorescein angiography showed early foveal hyperfluorescence in both eyes with late ill-defined leakage (Figure 1E and F); and autofluorescence images showed heterogeneous hyperfluorescence in the macula of both eyes (Figure 1G and H). Finally, a computerized 10–2 visual field threshold test (Humphrey Automated Perimeter; Humphrey Instruments, San Leandro, CA, USA), showed small pericentral scotomata in the right eye and a normal field in the left eye.

Figure 2 Optical coherence tomography. (A and B) Disruption of the outer retinal layers with nonspecific retinal thickening in both eyes at presentation. (C and D) Disruption of the inner segment/outer segment junction in both eyes, at 3 months after presentation.

Note: A and C are right eye; B and D are left eye.

The patient was treated with an oral steroid (Prednisone; H.J. Harkins Company, Inc., Grover Beach, CA, USA) 1 mg/kg for 4 weeks then tapered over 2 months. At 3 months, visual acuity remained impaired but improved to 20/30 in the right eye and 20/25 in the left eye.

At 3 months, optical coherence tomography showed improvement of the retinal thickening in both eyes. The hyperreflective line representing the inner segment/outer segment junction was disrupted in the right eye and the left eye (Figure 2C and D). The visual field improved and no scotoma was detected in the right eye.

Discussion

Laser pointer devices are a common and essential part of everyday life. This may lead to an increasing number of exposures to this type of laser device. However, there is debate about the ocular risks posed by inadvertent exposure to standard laser pointer devices, with the presence of an actual laser-induced injury often inconclusive or entirely absent in some studies.^1–3 Literature supporting laser pointer-induced retinal injury has been limited to only a few articles on class 3A red laser pointers, and even less literature exists on the retinal hazards of class 3A green laser pointers. In the literature, retinal lesions induced by laser pointers (both green and red devices) include foveal granularity, perifoveal drusenoid-like deposits, or foveal ring-shaped hypopigmented lesions, subretinal hemorrhage, vitreous or chorioretinal hemorrhage, retinal edema, scars in the pigment epithelium, and rarely choroidal neovascularization.⁴ Comparison of the retinal findings in our patient with those of other reported cases in the literature caused specifically by green lasers are listed in Table 1.

Table 1 Reported cases in the literature of retinal damage caused specifically by green lasers

Reference	Age (years)	Eye	Wavelength of laser (color)	Initial fundus findings	Initial OCT findings	Initial FAF findings	Initial FA findings	F/U	Findings at last F/U
Fujinami et al^Citation8	11	OD	Green, unknown wavelength, unknown power	Macular yellow exudate-like lesion or fibrous tissue surrounded by subretinal hemorrhage OD	–	–	n/s	36M	TD-OCT at 24 months F/U, macular CNV OD
Wyrsch et al^Citation10	15	OU	Green, unknown wavelength, 150 mW (class 3B)	Multiple tiny scars OD Macular edema and central subretinal hemorrhage OS	–	–	–	4M	On examination, foveal hyperpigmented scar OU
Ziahosseini et al^Citation11	Teens	OU	Green, unknown wavelength, unknown power	Foveolar burns with hyperpigmented borders OU	Subfoveal disturbances in the RPE OU	–	Foveolar window defect (ie, late leakage) OU	–	–
Hossein et al^Citation12	25	OD	Green, wavelength 532 nm, 3.5–4.5 mW (class 3A)	Yellow-white spot at foveola OD	On SD-OCT, foveolar full-thickness hyper-reflective signal OU	–	n/s	6M	On SD-OCT, residual disruption of retinal layer OD
Pollithy et al^Citation13	11	OU	Green, 532 ± 10 nm, < 100 mW (class B)	Circular-shaped defects of RPE with surrounding hyperpigmentation in fovea OU	On TD-OCT, foveolar disruption of retinal layer at RPE photoreceptor layer OU	Irregular areas of reduced autofluorescence in fovea OU	–	–	–
Dirani A (current study)	13	OU	Green, 532 nm, 5 mW (class 3A)	Foveolar yellowish, oval-shaped, drusenoid-like lesions OU	Disruption of outer retinal layers with nonspecific thickening OU	Foveolar areas of heterogenous hyperfluorescence OU	Foveolar late ill-defined leakage OU	3M	Disruption of IS/OS junction

Abbreviations: FAF, fundus autofluorescence imaging; FA, fluorescein angiography; F/U, follow-up; IS/OS, inner segment/outer segment; RPE, retinal pigment epithelium; TD-OCT, time domain optical coherence tomography; SD-OCT, spectral domain optical coherence tomography; OU, both eyes; OD, right eye; OS, left eye; CNV, choroidal neovascularization; M, months; n/s, non specified.

According to Barkana and Belkin, several factors contribute to laser-related retinal damage, and these can be divided into two categories, ie, laser-related factors (wavelength of the radiation; pulse duration; and energy level of the beam) and patient-related factors (size of the pupil, with injury being more severe in larger pupil sizes; degree of retinal pigmentation, with dark-skinned individuals suffering more severe injury than light-skinned ones; proximity of incident beam to the fovea; and refraction status, with damage being more severe in emmetropic eyes due to the laser beam being more focused on the retina).⁵ Also, experimental studies that have evaluated the clinical and histopathologic effects of laser pointers in eyes undergoing enucleation for melanoma concluded that green laser pointers (490–575 nm) are more damaging to the retina than red laser pointers (635–750 nm).^1,6

Laser-induced damage to the retina is even more concerning in children and infants than in adults. Whereas adults terminate accidental laser pointer exposure in less than 0.25 seconds by pupil, blink, and aversion responses,⁷ children have been reported to display “unusual” behavior, ie, staring for a prolonged period of time into the laser beam without blinking or averting the eye.⁸

Current medical therapy for retinal injury is mainly limited to corticosteroids on an undetermined regimen and has variable results.⁵ Final visual acuity ranges from 20/20 to 20/60 vision, and this depends on the size and location of the macular lesion.⁴

In recent years, cheap laser pointers are increasingly being used as toys for children. While shrinking in size, handheld laser pointers are becoming increasingly more powerful, and safety is becoming a public health issue.⁹

The potential vision-threatening hazards caused by mishandling laser pointers, even class 3A lasers, emphasize the importance of cautious and appropriate use of these devices. Recommendations regarding the purchase and use of these devices are being reconsidered. Further restrictions on their sale and use by the general public will require more than simple recommendations; legislation will have to be passed and enforced by governmental bodies.

Disclosure

The study did not receive any external funding. None of the authors has any proprietary, commercial, or financial interest in any of the products mentioned in this paper.