Abstract
Background
Healthcare systems are under increasing strain, predominantly due to chronic non-communicable diseases. Connected healthcare technologies are becoming ever more capable and their components cheaper. These innovations could facilitate both self-management and more efficient use of healthcare resources for common respiratory diseases such as asthma and chronic obstructive pulmonary disease. However, newer technologies can only facilitate major changes in practice, and cannot accomplish them in isolation.
Focus of review
There are now large numbers of devices and software offerings available. However, the potential of such technologies is not being realised due to limited engagement with the public, clinicians and providers, and a relative paucity of evidence describing elements of best practice in this complex and evolving environment. Indeed, there are clear examples of wasted resources and potential harm. We therefore call on interested parties to work collaboratively to begin to realize the potential benefits and reduce the risks of connected technologies through change in practice. We highlight key areas where such partnership can facilitate the effective and safe use of technology in chronic respiratory care: developing data standards and fostering inter-operability, making collaborative testing facilities available at scale for small to medium enterprises, developing and promoting new adaptive trial designs, developing robust health economic models, agreeing expedited approval pathways, and detailed planning of dissemination to use.
Conclusion
The increasing capability and availability of connected technologies in respiratory care offers great opportunities and significant risks. A co-ordinated collaborative approach is needed to realize these benefits at scale. Using newer technologies to revolutionize practice relies on widespread engagement and cannot be delivered by a minority of interested specialists. Failure to engage risks a costly and inefficient chapter in respiratory care.
Introduction
The traditional model of face-to-face healthcare delivery is becoming increasingly unsustainable as demand continues to increase.Citation1 The introduction of new technologies has addressed demand and efficiency issues in other industries, and may permit cost-effective solutions to healthcare needs. Chronic respiratory disease is a prototypical example of chronic care in which technology-mediated care might improve outcomes within a manageable cost framework. The potential of novel connected technologies must be considered in the context of the challenges associated with implementation at a large enough scale to provide sustainable solutions. In this article, we briefly review the types and promise of available solutions and then focus on solutions to overcome barriers and facilitate implementation.
Healthcare systems under strain
The need for new models of working
Healthcare systems are under growing pressure from an aging and increasingly multimorbid population.Citation2 Not only is the number of patients rising but so too is the complexity of presentations and the array of specialist tests and interventions tailored available to address individual patient needs. The combination of these factors has led to a growing resource crisis over the past decade. The Royal College of Physicians’ Future Hospital Commission ReportCitation3 observes that had the change in health system demands taken place over the period of a year, it would have been deemed a “national disaster” prompting a suitable response. Yet the fact it has “crept up” has resulted in a distinct lack of direct action.
Different healthcare systems face different pressures. In lower income countries, there are growing populations and a scarcity of resources and trained healthcare staff.Citation4 In higher income countries, there is a growing awareness that overuse of tests and investigations is wasteful and potentially harmful,Citation5 leading to initiatives such as the Choose Wisely Campaign.Citation6 It is evident that usual models of face-to-face patient–physician consultation in out-patient or community settings will become increasingly stretched and unable to provide safe and timely care. New ways of working are required to allow clinicians to support effective self-management at scale. This will require remote data capture in a way that enables their subsequent incorporation into existing clinical records, controls for the limitations of self-report, and captures the influence of external environmental and seasonal influences on disease state. This would allow reliable benchmarking against care patterns and thus integration of patient stratification algorithms into intelligent Clinical Decision Support Systems (CDSS).
Chronic respiratory disease as a prototype for technology-supported management
Over 500 million people worldwide have chronic airways disease, with many millions more experiencing common conditions such as sleep disordered breathing and pulmonary fibrosis.Citation7 Individuals with chronic lung diseases also have a higher prevalence of chronic comorbidities related to their conditions and related treatments such as cardiovascular disease, diabetes, obesity, osteoporosis and depression.Citation8 Engaging with people who have a respiratory diagnosis can, therefore, also present an opportunity for positive interventions in these areas. Thus, respiratory medicine is well positioned as a conduit for new ways of working that focus on supporting shared care and self-management through improvements in remote assessment and monitoring.
The concept: what can new technologies offer?
Monitoring diseases, behavior and their context
The past decade has seen a steep change in areas of technology relevant to healthcare. Sensors related to physiological measurement have become smaller, cheaper, more capable and more accurate.Citation9,Citation10 This provides the possibility of remote assessment and monitoring of health and disease.Citation11 Tools such as electronic peak flow meters can provide standardized time-stamped information that can inform clinical decision-making.Citation12 Devices are not only becoming evermore capable and flexible, but also increasingly affordable, ubiquitous and interconnected. There are exciting possibilities to gather data from a user’s daily activities to contextualize and enrich monitoring data. This may be through existing devices such as activity monitors, or by adding sensors to items the individual uses daily such as an inhaler. Moving toward the “Internet of Things” has the potential to reduce issues with stand-alone telehealth systems that require dedicated time for interactions using operating systems unfamiliar to the user.Citation13,Citation14 The large volume of data recorded by sensors in mobile devices can be stored and analyzed close to the point of capture, and can be combined with other information in the cloud such as atmospheric, pollen count or pollution data ().
Intervention based on novel data
Remote monitoring connected to the patient’s own phone or computer offers more opportunities to promote behavioral change. Repeated, in-context feedback prompted by modest amounts of specific information may support more sustained improvements than an annual review based on a large volume of (often historic) information. For example, results of a measure of interest (e.g., taking inhalers regularly) can be fed back to the user and compared against a personal history and target standards, and linked to specific adherence interventions, such as daily reminders for missed doses, visual feedback of monthly performance, or advice by a healthcare professional. This simple feedback of current behavior is only one aspect of an ideal, carefully-designed, integrated system of assessment and intervention. Such a system could address a range of specific patient behaviors: supporting self-regulatory capacity and skills, encouraging adjuvant activities, and providing information that emphasises opportunities and choice.Citation15
Yet it is not only patient behavior that may be altered in this way; new monitoring technologies offer a major opportunity to shape and guide clinicians and their practice behaviors. Moreover, the availability of multimodal remote assessment could increase the confidence of clinicians in undertaking “n of 1” trials of treatment, a valuable asset in heterogeneous conditions such as asthma.Citation16 As newer technologies become widely adopted, data from remote sensors will be incorporated into decision support tools, including risk prediction models. This could permit faster and more consistent clinical review, particularly if care is fragmented across several providers.
Current state of remote monitoring and assessment
There is evidently great potential in the use of remote monitoring and connected technologies for chronic respiratory conditions. At the time of writing, two main types of technology are being offered to attempt to realize some of this potential: mobile phone application and connected devices.
Mobile phone applications
Recent reports estimate there are over 150,000 apps, developed by thousands of companies and individuals.Citation17 The majority of these are in English, but the Chinese and other global markets are rapidly expanding.Citation18 The number of apps available suggests individuals are willing to engage with this platform for education or support (). A recent American study found that more than half of smartphone users had downloaded a health-related app and placed high levels of trust in their accuracy.Citation19 This enthusiasm appears to extend to respiratory disease as over 90% of adolescents using personal asthma action plans based on a mobile device reported they felt better able to manage their asthma.Citation20
Figure 2 Number of available mobile phone applications for asthma.
![Figure 2 Number of available mobile phone applications for asthma.](/cms/asset/49df5e10-53be-4a16-b4aa-df342cd0a0dc/dpor_a_132316_f0002_b.jpg)
However, the large and increasing number of apps available also suggests that, despite consumer and developer enthusiasm, there are few offerings that fulfill their remit and are widely and persistently used.Citation21 This may reflect the lack of clinical benefit from stand-alone software: a large UK-based randomized controlled trial of a mobile phone app for asthma monitoring demonstrated no clinical benefit, but added expense.Citation22
From the clinical perspective, mobile applications herald the potential to support clinicians’ decision-making by (for example) facilitating multifactorial risk assessment calculationsCitation23 or assisting in attitudinal profiling.Citation24 It remains uncertain how much value is added by the delivery through a mobile device beyond other interfaces that may be less costly.
Connected devices
Low-cost electronics integrated with standard equipment now permit the collection and combination of routine data such as weight and peak expiratory flow. Similar technology allows the monitoring of medication administration such as that used in so-called smart inhalers, now a well-established research toolCitation25–Citation27 beginning to see targeted use in clinical settings.Citation28
Ingestible technologies also show promise for oral medication.Citation29 Tools such as pulse oximeters and activity monitors that were confined to in-patient or specialist use are now routine consumer productsCitation30 and could be incorporated into smartphones.Citation31 As the data from these monitors can now be collected into existing platforms, such as Apple Health, the development burden on small to medium enterprises (SMEs) is potentially reduced and the market is likely to become increasingly congested.Citation32
As with mobile apps, connected devices often secure initial engagement but their long-term clinical benefit is less clear. Although devices such as smart inhalers provide accurate data,Citation33 they have not yet been studied as part of a holistic behavioral change system. Small studies of the isolated introduction of smart inhalers have not shown an increase in medication adherence or symptom improvement.Citation34
Technologies as a potential hazard
Primum non nocere
New ways of working are always accompanied by new challenges and risks. Historically, most medical innovations and technologies have been developed to rigorously-defined safety standards. Emerging technologies such as apps and smart devices, however, are made available directly to consumers, seldom with peer-reviewed publications describing their scientific rationale or reported effectiveness. The absence of the usual levels of protection afforded to patients’ risks lower quality standards, such as software that contain errors in advice or miscalculated peak flow measurements, reaching the patient unimpeded.Citation21 The combination of potentially inaccurate measurement and algorithmic misinterpretation is a concern in this large and growing market. The QRISK® cardiovascular risk assessment tool, for example, is integral to many thousands of healthcare interactions in UK primary care practice. Yet it was found to contain a calculation error that could erroneously recommend the commencement of statin therapy, resulting in a suspension of its use in 2015.Citation35
The rapid evolution of information technologies requires intelligent synthesis of vast amounts of data and expert opinion and presentation in a readily accessible format if it is to be meaningfully used. The generation and curation of mass amounts of data often outpaces data visualization capabilities and infrastructure and can raise challenging ethical dilemmas. Devices such as continuous positive airway pressure (CPAP) machines are now able to transfer data directly to providers,Citation36 and mechanisms are being rolled out to permit patients to upload information directly into their primary care records.Citation37 It is unclear if patients believe the data stream from their device is being continuously monitored, and (if so) what the implications of this understanding might be on the personal level of responsibility patients assume for their wellbeing.
Data security
The practice of medicine is predicated on confidentiality between clinician and patient. In recent years, however, connected technologies to manage chronic conditions or promote healthy living have raised new issues in patient confidentiality. Recognition of the potential use of video communication platforms such as Skype,Citation38–Citation40 for example, has led to the suggestion that it may sometimes be in a patient’s best interest to trade off absolute data security against the value of receiving a remote specialist opinion: “better cured than secured.” In the context of smart phones and connected devices as self-management supports, connectivity results in a convergence of commercial, clinical and research perspectives on data management and confidentiality.
In addition to breaches of confidentiality at the individual patient level, cyber-attacks against healthcare providers are increasingly becoming common and the industry is lagging behind others in its capability to secure vital data.Citation41 It seems unlikely that app and device providers will be able to ensure data security in the face of evermore sophisticated cyber-attacks. Such data breaches may have serious consequences for individuals, particularly if sensitive incidental data is captured or individual devices can be remotely manipulated.Citation42 Also of concern, at a population level, is the increasing commercialization of healthcare data by providers. Healthcare records are sold en masse to industry and users of health-related apps and websites and used to inform targeted advertising. Data on visits to UK National Health Service webpages, for example, is now being shared with Amazon.Citation43
In the preceding sections, we have described the potential and increasing availability of connected technologies and targeted software. We have also highlighted the relative lack of study data supporting their routine clinical use, and the potential risks of uncontrolled implementation. The respiratory community therefore faces a major challenge and intervention is required to understand why technology-based solutions are not fulfilling their potential so that the relevant issues can be appropriately addressed.
Why might technology based solutions not fulfil their potential?
Economics
Medical apps are usually created by small enterprises and offered free or at minimal cost (on average <£1).Citation44 At such low levels of return, there is little capacity or incentive for investment in research and development to deliver high-quality medical products, certainly in comparison to the activity of pharmaceutical companies. This issue is compounded by the rate of change in operating systems and hardware platforms: there is a race to deliver apps to market before they are no longer technically functional. In contrast, the approvals process for medical interventions is lengthy and technical. Developers receive relatively little return on investment and, as they are not usually healthcare providers, do not stand to gain from the health benefits their app may afford. An important step toward future technologies potentially having greater clinical value and longevity would therefore appear to be co-production with providers. This concept might focus efforts on interventions where there is a clinical and financial step-change, such as reducing hospital admissions or the use of high-cost drugs. Co-production would also ensure both parties have a clear understanding of the financial implications of deploying a new technology beyond the unit cost (personnel training, infrastructure, etc.). Involving payers in co-production may also reduce the drive for desire-rather than need-led content development ().
Utility
A notable aspect of many apps and connected devices is the lack of clarity in their specific purpose. As with any medical intervention, the likelihood of efficacy is dependent on defining a target population, a specific intervention, and a primary outcome. The all-encompassing approach of most apps may be influenced by a relative lack of understanding of respiratory diseases, or market forces pushing developers to seek the largest potential market. Most apps are not developed in consultation with experts or patients.Citation45,Citation46 It is apparent that co-production with end users could help focus development on relevant and tractable clinical and behavioral or activation problems. This may begin to address the current “solution first” issue of new technologies being brought to market without first establishing they are appropriately addressing a meaningful issue.Citation47 Co-production between clinicians and patients (as previously discussed) could reduce the focus on technical capability and focus instead on utility and data that can be successfully and meaningfully curated.
Demonstrating effectiveness, even of well-designed technologies, may also be a challenge, especially if it is aimed at hard-to-reach individuals who do not usually engage with health services. A randomized controlled trial of mobile phone-based self-monitoring for adolescents with asthma recruited only 2.4% of those invited.Citation22 This lack of engagement may also reflect a gap in perceived quality between the health-related technology on offer and other consumer technologies.
The rush to market to capitalize on evolving functionality and avoid obsolescence inevitably limits the time spent incorporating ergonomic principlesCitation48 into the design of technologies or consulting with potential end-users before being launched. This is particularly true for SMEs that lack institutional memory. Resultant offerings may have shortcomings in their high demand for data entry, suboptimal interface, limited functionality, and information provisionCitation49 that limit user engagement. In the longer term, these issues may be partially overcome through applying new software behind common social media platforms such as Facebook or intelligent assistants such as Siri. However, co-production with patients will remain an essential component of successful software or device design. Engagement with patient organizations and charities will facilitate the design and testing process,Citation50 as will developers leveraging learning from other projects such as the large European Union-funded collaborative study MyAir-Coach (http://www.myaircoach.eu/myaircoach/). A further challenge in achieving true functional effectiveness will be the routine integration and interoperability of the device and/or the data collected within the patient electronic healthcare recordCitation51 and within integrated healthcare pathways.Citation52
Creating an environment conducive to development and deployment
Current standards
Although regulators classify apps or devices that record data on health or disease, those that stop short of suggesting an alteration or that essentially digitize previously paper-based data forms are largely classified as “non-medical”. As a result, there is widespread use of unregulated connected devices and apps with the potential to influence health behaviors and limited high-quality independent information available to guide users in navigating the options available to them. Furthermore, as noted, the great majority of these offerings have not been robustly developed or tested. Not only does this mean individual apps or devices are often flawed in terms of their basic functionality, but it is also unclear if their use is associated with any benefit.Citation53 The lack of generalizable knowledge from robust research studies is further hampering the iterative improvement of technology-supported management. Developers and clinicians must attempt to keep abreast of scanty information scattered across journal articles, webpages, white papers, and reports.
In response to this broad issue, many standards, checklists, and guidelines have been produced on the implementation of e-health, and there is now an e-health aspect to most recommendations for complex interventions. The World Health Organization mHealth Technical Evidence Review Group has also developed a checklist for mHealth Evidence Reporting and Assessment (mERA)Citation54 (). The mERA document is welcome, but does highlight two key limitations common to such recommendations. Although it provides a solid basis for assessing reports of studies of technology supported care, it gives little attention to the specifics of intervention development: there is a mention of “user feedback” but no details of co-development with clinicians, payers or patients. There is also little practical guidance for innovators on how the evidence requested might be generated.
Table 1 World Health Organization mERA reporting checklist for respiratory studies
Practical steps to widespread deployment
Respiratory clinicians and healthcare providers should be wary of deploying any technology-based solution that is not supported by a peer-reviewed publication that complies with the mERA reporting guidance or any subsequently developed respiratory-specific iteration of this. However, as a community, it is essential that careful thought is given to the pragmatic question of how robust evidence for a device or software can be delivered and disseminated before the technology becomes outdated and/or loses its commercial advantage.
We propose that eight core areas of activity would help facilitate the development of needed solutions, assess their effectiveness and support their implementation in an engaged community of people with respiratory disease and the clinicians with whom they interact (summarized in Box 1).
Research
Establish research centers
SMEs do not have the budget to undertake clinical studies in the same manner as major pharmaceutical companies. Establishing innovative testing facilities for connected technologies could enable innovators to access relevant protocols, experts and patient groups in a timely and cost-effective manner. This will require initial investment from healthcare providers or research funders but will improve co-production, research volume and quality. Asthma UK’s AsthmaLab is an example of a charitable organization piloting a co-creation approach to digital health solutions focused on asthma. This type of approach explores how to harness the willingness of both people with asthma and asthma-interested clinicians to volunteer to develop robust, agile, cost effective testing. Centers with a focus on research in this area can also act as hubs from which to disseminate results, highlighting how newer technologies can provide opportunities to improve respiratory care.
Synthesize and simplify guidance
The amount of information on common respiratory conditions, behavior change, intervention development, implementation science, and medical research methods is overwhelming to non-specialists. Parsimonious disease-specific guidelines for developing technology-mediated management solutions for common conditions, disseminated in a user-friendly format to current and potential developers would be of significant benefit. These guidelines, developed in collaboration with all stakeholders, could also provide background financial information to support the movement toward mature health economic models for new technologies. When choosing an app or device, end-users could simply check the relevant guidelines had been adhered to in order to facilitate and improve their decision-making.
Use adaptive study designs
There is a growing recognition of the need to adopt newer, more flexible and responsive trial designs to address clinical management questions in current practice.Citation55 The use of adaptive designs and umbrella trials will better facilitate the evaluation of multiple solutions with fewer restrictions on other aspects of care. New trial designs can also be used to understand highly contextualized behavior in subgroups. Methodologists and researchers could promote the use of such methods by developing practical guides and highlighting best practice examples. The increased efficiency of newer study designs may also reassure participants that they are far less likely to face relatively long-term allocation to a study arm that uses an unhelpful or outmoded technology.
Consider the economics of technology deployment
Our understanding of how best to deploy new technologies lags behind the technical development. Research is required to investigate the optimal method of incorporating new data streams into CDSS and, crucially, into the health economics around deployment. It is unclear which technologies represent good value when costs of training staff, educating patients, improving technical infrastructure and managing plentiful data are taken into consideration: only when more mature health economic models are available will there be a clear picture of the role of connected devices going forward. This would require close collaboration between health providers and health economists to develop and promote the use of such models. The potential cost and time efficiencies of using newer technologies should motivate clinicians to seek out such collaborations.
Availability
Expedite approval
Regulators such as the US Food and Drug Administration and the UK’s Medicines Healthcare Products Regulatory Authority have developed clear guidance explaining which innovations should be subject to their approval system. However, developers are still reluctant to pursue approval as they perceive the process to be time-consuming and complex. We urge regulators to continue to engage with healthcare providers and developers to ensure approvals can be made in a timely fashion, potentially with the introduction of new, proportionate pathways.
Develop solutions for inter-operability
To leverage the potential of newer technologies fully, it will be essential to share data between sensors, mobile devices, and patient records. A good deal of work is still to be done to agree standards for routinely collected data, with the concern that we may end up with multiple unconnected devices and pieces of software. These would then rely on manual review and repetitive information transfer (with the risk that historic data could be lost) and the additional cost of users repeatedly needing to learn new interfaces. Solutions for inter-operability need urgent consideration by technology specialists. These specialists should find other stakeholders such as health providers and motivate end-users (clinicians, patients) to contribute to these discussions as they seek to avoid time-consuming and frustrating incompatibility issues.
Dissemination to use
Build a central solution showroom
It is insufficient to develop and approve innovative solutions without a clear framework for their dissemination to intended end-users in an accessible and engaging manner. There have been some initiatives to create such an offering (e.g., the Health Tools LibraryCitation56), but we currently lack a system whereby a person with a chronic respiratory condition or a nurse in primary care could easily identify and access a high-quality product suitable for them. Such an initiative would have a short-term benefit for health providers, professionals and people with respiratory disease, so should attract their engagement in development, alongside patient organizations. Using a showroom to highlight potential benefits and to make it easier to access technology based solutions improves the likelihood of time-pressured or more sceptical end-users trying new approaches.
Provide clear indications and instructions for use
Medical interventions proven effective in research studies should be used in a manner that is consistent with those studies. In usual practice, decisions are informed by guidelines and appropriate prescribing is safeguarded by pharmacists. In contrast, new technologies are less likely to feature by name in guidelines given their relative rate of revision, and there will be less oversight of delivery to patients. Learned institutions and healthcare providers will therefore need to produce clear general guidance on the practicalities of implementation, and invest in training staff on applying this guidance in routine care. Individual products require a standardized summary of characteristics provided by developers in line with this guidance to facilitate their rapid integration in routine care. Clinicians delivering respiratory care will have more confidence in recommending new technologies to patients with this familiar style of infrastructure, increasing their experience and engagement in this developing area.
Conclusion
The increasing demand on healthcare services consequent to increasing prevalence of chronic diseases cannot be addressed using traditional working practices. The large-scale deployment of newer connected technologies has the potential to empower self-management in respiratory diseases and facilitate expert review. However, this would require major changes in the way respiratory diseases are currently managed. These changes can only be realised through diverse collaborative efforts in research and clinical care, not left to the technology-interested minority. To achieve the required goals, innovative products must be developed in partnership with patients, clinicians, and providers. These products must be robustly tested and approved using newer approaches, but they must also be readily accessed and used.
We believe that we are at a tipping point in the management of chronic respiratory disease. Unless all parties work collaboratively to realize the potential benefits, the thousands of flowers of innovation that are beginning to bloom will die in the absence of facilitatory conditions, accepted development quality standards, robust verification of utility, and ready access for end-users. If this does not occur, technologies will remain a confusing and expensive distraction at a time when resources are increasingly stretched.
Author contributions
JDB, AC and ALD had the initial idea for the manuscript. RWC, JDB and DR drafted initial sections. The concept and content were revised at meetings with RAM, KB, and DP. The manuscript was finalized by ALD, AC and JDB and all authors approved this. All authors contributed toward data analysis or literature search, drafting and revising the paper and agree to be accountable for all aspects of the work.
Acknowledgments
We are grateful to Joseph Clift, Daisy Ellis, and Dan Poscover for constructive discussions in this area.
This manuscript is based on discussions that took place around meetings of the Respiratory Effectiveness Group.
Disclosure
RWC has a patent on the use of acoustic analysis to assess inhaler use. DP has previously had research funding to develop software to assess inhaler technique. The other authors report no conflicts of interest in this work.
References
- BousquetJJorgensenCDauzatMSystems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policiesCurr Pharm Des201420385928594424641234
- BarnettKMercerSWNorburyMWattGWykeSGuthrieBEpidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional studyLancet20123809836374322579043
- Future hospital: caring for medical patients. A report from the Future Hospital Commission to the Royal College of PhysiciansLondonFuture Hospital Commission2013 Available from: https://www.rcplondon.ac.uk/projects/outputs/future-hospital-commissionAccessed May 3, 2017
- World Health OrganisationGlobal Strategy on Human Resources for Health: Workforve 2030GenevaWorld Health Organisation2016
- PrasadVVandrossAToomeyCA decade of reversal: an analysis of 146 contradicted medical practicesMayo Clin Proc201388879079823871230
- CasselCKGuestJAChoosing wisely: helping physicians and patients make smart decisions about their careJAMA2012307171801180222492759
- MarciniukDFerkolTNanaARespiratory Diseases in the World: Realities of today, Opportunities for TomorrowForum of International Respiratory Societies2013 Availabe from: https://www.ersnet.org/pdf/publications/firs-world-report.pdfAccessed March 29, 2017
- GershonASWangCGuanJToTBurden of comorbidity in individuals with asthmaThorax201065761261820627918
- CiutiGRicottiLMenciassiADarioPMEMS sensor technologies for human centred applications in healthcare, physical activities, safety and environmental sensing: a review on research activities in ItalySensors (Basel)201515176441646825808763
- WangCLuWNarayananMRRedmondSJLovelNHLow-power technologies for wearable telecare and telehealth systems: a reviewBiomed Eng Lett20155119
- PiwekLEllisDAAndrewsSJoinsonAThe rise of consumer health wearables: promises and barriersPLoS Med2016132e100195326836780
- MeuricSLeroyMRaffestinBBidatECompliance with and acceptability of a new electronic peak flow meter, the PiKo-1Rev Des Mal Respir2005226 Pt 1935941
- GreenhalghTProcterRWhertonJSugarhoodPHinderSRouncefieldMWhat is quality in assisted living technology? The ARCHIE framework for effective telehealth and telecare servicesBMC Med2015139125902803
- LaiAMKaufmanDRStarrenJSheaSEvaluation of a remote training approach for teaching seniors to use a telehealth systemInt J Med Inform2009781173274419620023
- MichieSWoodCEJohnstonMAbrahamCFrancisJJHardemanWBehaviour change techniques: the development and evaluation of a taxonomic method for reporting and describing behaviour change interventions (a suite of five studies involving consensus methods, randomised controlled trials and analysis of qualitative data)Health Technol Assess201519991188
- SchorkNJPersonalized medicine: time for one-person trialsNature2015520754960961125925459
- CostelloSHow Many Apps are in the App Store?2016 Available from: https://www.lifewire.com/how-many-apps-in-app-store-2000252Accessed March 29, 2017
- PerezSChina overtakes the U.S. in iOS App Store revenue2016 Available from: https://techcrunch.com/2016/10/20/china-overtakes-the-u-s-in-ios-app-store-revenue/Accessed March 29, 2017
- KrebsPDuncanDTHealth app use among us mobile phone owners: a national surveyJMIR Mhealth Uhealth201534e10126537656
- BurbankAJLewisSDHewesMMobile-based asthma action plans for adolescentsJ Asthma201552658358625494553
- HuckvaleKMorrisonCOuyangJGhaghdaACarJThe evolution of mobile apps for asthma: an updated systematic assessment of content and toolsBMC Med2015135825857569
- RyanDPriceDMusgraveSDClinical and cost effectiveness of mobile phone supported self monitoring of asthma: multicentre randomised controlled trialBMJ2012344e175622446569
- BlakeyJDPriceDBPizzichiniEIdentifying risk of future asthma attacks using UK medical record data: a respiratory effectiveness group initiativeJ Allergy Clin Immunol Pract2016
- David-WangAPriceDChoSHDevelopment and validation of an attitudinal-profiling tool for patients with asthmaAllergy Asthma Immunol Res201791435127826961
- PatelMPilcherJReddelHKPredictors of severe exacerbations, poor asthma control, and beta-agonist overuse for patients with asthmaJ Allergy Clin Immunol Pract20142675175825439367
- SulaimanICushenBGreeneGObjective assessment of adherence to inhalers by COPD patientsAm J Respir Crit Care Med2017195101333134327409253
- MerchantRKInamdarRQuadeRCEffectiveness of population health management using the propeller health asthma platform: a randomized clinical trialJ Allergy Clin Immunol Pract20164345546326778246
- HeaneyLGDjukanovicRWoodcockAResearch in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)Thorax201671218718926205878
- BelknapRWeisSBrookensAFeasibility of an ingestible sensor-based system for monitoring adherence to tuberculosis therapyPLoS One201381e5337323308203
- LipnickMSFeinerJRAuPBernsteinMBicklerPEThe accuracy of 6 inexpensive pulse oximeters not cleared by the food and drug administration: the possible global public health implicationsAnesth Analg2016123233834527089002
- FreedmanBScreening for atrial fibrillation using a smartphone: is there an app for that?J Am Heart Assoc201657
- PatrickJRHow mHealth will spur consumer-led healthcaremHealth201511428293572
- PilcherJHollidayMEbmeierSValidation of a metered dose inhaler electronic monitoring device: implications for asthma clinical trial useBMJ Open Respir Res201631e000128
- MortonRWElphickHERigbyASSTAAR: a randomised controlled trial of electronic adherence monitoring with reminder alarms and feedback to improve clinical outcomes for children with asthmaThorax201772434735427815524
- Matthews-KingAPulseLondonCogora Ltd2016
- StepnowskyCJPalauJJMarlerMRGiffordALPilot randomized trial of the effect of wireless telemonitoring on compliance and treatment efficacy in obstructive sleep apneaJ Med Internet Res200792e1417513285
- TaylorJLiverpool EchoLiverpoolTrinity Mirror2015
- MosierJJosephBSaklesJCTelebation: next-generation telemedicine in remote airway management using current wireless technologiesTelemed J E Health2013192959823215736
- GlauserWThe skype solutionCMAJ201118312E79821825049
- RaineySThe SpectatorLondonSpectator 1828 Ltd2014
- LunaRRhineEMyhraMSullivanRKruseCSCyber threats to health information systems: a systematic reviewTechnol Health Care20162411926578272
- CleryDThe privacy arms race. Could your pacemaker be hackable?Science2015347622149925635085
- LibertTGrandeDAschDAWhat web browsing reveals about your healthBMJ2015351h597426572794
- LiuCZAuYAChoiHSEffects of freemium strategy in the mobile app market: an empirical study of google playJ Manage Inf Syst2014313326354
- HamiltonADBradyRRMedical professional involvement in smartphone ‘apps’ in dermatologyBr J Dermatol2012167122022122283748
- RosserBAEcclestonCSmartphone applications for pain managementJ Telemed Telecare201117630831221844177
- McCartneyMHow do we know whether medical apps work?BMJ2013346f181123516158
- MartinJLNorrisBJMurphyECroweJAMedical device development: the challenge for ergonomicsAppl Ergon200839327128318061139
- StoyanovSRHidesLKavanaghDJZelenkoOTjondronegoroDManiMMobile app rating scale: a new tool for assessing the quality of health mobile appsJMIR Mhealth Uhealth201531e2725760773
- BartlettSJBarnesTMcIvorRAIntegrating patients into meaningful real-world researchAnn Am Thorac Soc201411Suppl 2S11211724559023
- MarcegliaSFonteloPRossiEAckermanMJA standards-based architecture proposal for integrating patient mhealth apps to electronic health record systemsAppl Clin Inform20156348850526448794
- European Innovation Partnership on Active and Healthy Ageing, Action Plan B3; Mechanisms of the Development of Allergy, WP 10; Global Alliance against Chronic Respiratory Diseases BousquetJAddisAAdcockIIntegrated care pathways for airway diseases (AIRWAYS-ICPs)Eur Respir J201444230432324925919
- AgarwalSPerryHBLongLALabriqueABEvidence on feasibility and effective use of mHealth strategies by frontline health workers in developing countries: systematic reviewTrop Med Int Health20152081003101425881735
- AgarwalSLeFevreAELeeJGuidelines for reporting of health interventions using mobile phones: mobile health (mHealth) evidence reporting and assessment (mERA) checklistBMJ2016352i117426988021
- BhattDLMehtaCAdaptive designs for clinical trialsN Engl J Med20163751657427406349
- NHS_ChoicesNHS Health Apps Library2016 Available from: http://www.nhs.uk/tools/pages/toolslibrary.aspxAccessed May 3, 2017
- WuACCarpenterJFHimesBEMobile health applications for asthmaJ Allergy Clin Immunol Pract201533446448e441e41625725939