Depot Buprenorphine Injection in the Management of Opioid Use Disorder: From Development to Implementation [Corrigendum]

This article refers to:

Depot Buprenorphine Injection In The Management Of Opioid Use Disorder: From Development To Implementation

Ling W, Shoptaw S, Goodman-Meza D. Subst Abuse Rehabil. 2019;10:69–78.

The authors of this paper have advised that Table 1 is incorrect. The authors advised that they had listed values for Cmax and Ctrough after a single dose of Brixadi (CAM2038) and not steady state, as it was provided for Sublocade. The new Table 1 reflects the Brixadi steady state concentrations for a more direct comparison with Sublocade.

The correct Table 1 is as follows:

Table 1 Comparison of Long-Acting Formulations of Buprenorphine FDA-Approved for Treatment of Opioid Use Disorder

Brand Name	Probuphine	Sublocade	Brixadi (US) or Buvidal (Europe/Australia)
Molecular name		RBP-6000	CAM2038
Pharmaceutical	Previously Braeburn, currently Titan	Indivior	Braeburn Pharmaceuticals/Camurus
Indicated population	Stable transmucosal buprenorphine dose of 8 mg or less for three months or longer	Initiated transmucosal buprenorphine (8–24 mg) for a minimum of 7 days.	Initiation of treatment in patients not already receiving buprenorphine or switching from transmucosal buprenorphine
Route of administration	Subcutaneous implant	Subcutaenous injection	Subcutaenous injection
Duration of effect	6 months	1 month	1 week or 1 month
Dosage	320 mg (Four 80 mg implants)	100 and 300 mg	8, 16, 24 and 32 mg (weekly) or 64, 96 and 128 mg (monthly)
Long acting technology	Ethylene vinyl acetate (EVA) polymer	18% (weight/weight) buprenorphine base in the ATRIGEL Delivery System	Prolonged release FluidCrystal injection depot technology
Location	Upper arm	Abdomen	Buttock, thigh, stomach (abdomen) or upper arm
FDA-approval	2016	2017	2018 (tentative)
Plasma concentrations (ng/mL)	Cmax	Cmax	Cmax
	3.23	4.88 (100 mg)	Weekly 4.3–6.9
		10.12 (300 mg)	Monthly 4.0–11.1
	Ctrough	Ctrough	Ctrough
	0.72	2.48 (100 mg)	Weekly 0.8–2.6
		5.01 (300 mg)	Monthly 1.3–2.1
Provider burden	+++	++	++
	Live training program	Supervised injection	Supervised injection
	Procedural competency	Monthly injections	Weekly or monthly injections
Special Handling Requirements	Requires implant procedure	Needs Refrigeration	No special requirements
	Need for removal or replacement every 6 months	Injection only under skin around umbilicus