Prevalence and correlates of coronary heart disease: first population-based study in Lebanon

Abstract

Background

Lebanon is experiencing a growing epidemic of coronary heart diseases (CHDs), as most low- and middle-income countries currently are. However, this growth can be attenuated if effective preventive strategies are adopted.

Purpose

To provide the first national population-based prevalence of CHD and to describe the profile of Lebanese adults with prevalent CHD.

Methods

We carried out a cross-sectional study using a multistage cluster sample across Lebanon. We interviewed residents aged 40 years and older using a questionnaire that captured the presence of CHDs and their risk factors (RFs).

Results

Our study showed that 13.4% of the Lebanese population aged ≥40 years suffer from a prevalent CHD. CHD seemed to appear more prematurely than in developed countries, and males seemed to be more subject to CHD than females until a certain age. CHD was associated with older age, male sex, a lower economic situation, hypercholesterolemia, hypertension, having a family history of premature cardiovascular diseases, and suffering from diabetes. However, smoking and waist circumference did not seem to have an independent effect on CHD, but rather an effect mediated by biological RFs.

Conclusion

This is the first nationwide endeavor conducted in Lebanon to assess the prevalence of CHD. This study also confirms the relevance of the classic RFs of CHD and their applicability to the Lebanese population, thus allowing for prevention strategies.

Keywords:

• coronary heart disease
• correlates
• epidemiology
• prevalence
• risk factors

Introduction

In 2010, ischemic heart disease was the leading cause of mortality worldwide.¹ Projections reveal that ischemic heart disease mortality in the Middle Eastern countries will increase at a higher rate compared to the other regions.^2,3 However, many acute myocardial infarction (MI) patients do survive, and many adults live with disabling symptoms related to coronary heart disease (CHD).¹ Therefore, measuring the burden of CHD requires estimating nonfatal CHD prevalence.

Furthermore, the disease pathogenesis being multifactorial, studying the association of CHD with societal, lifestyle, and classic risk factors (RFs) in different settings is primordial to adopt effective preventive strategies by acting on the core causes, allowing for a significant reduction in the incidence and prevalence of CHD.⁴ However, local data to inform health policy are inadequate in the Eastern Mediterranean region. Specifically in Lebanon, a lack of nationally representative data on the epidemiology of CHD has been reported.⁵ In fact, a review of the literature reveals that no study on the prevalence of CHD in Lebanon has been carried out. As for the profiling of people at risk of CHD, two studies were found; one focused on biological RFs,⁶ while the other explored socioeconomic disparities in heart disease.⁷

Our study was thus designed to determine a national population-based CHD prevalence in Lebanese people aged 40 years and older and to construct the profile of people living with CHD, using social, behavioral, and biological factors, in order to provide a more holistic image of the burden. This will allow more efficient and targeted health services.

Methods

Study design and population

The methodology presented in this paper has been previously described elsewhere.⁸ The data for this study were collected through a cross-sectional study, carried out between September 2013 and October 2014, using a multistage cluster sample across Lebanon. One hundred circumscriptions were randomly selected from the list of circumscriptions in Lebanon. From the list of dwellers provided by the local authorities, the selection of residents aged ≥40 years was done using a software program to ensure randomness. Data were gathered from a face-to-face interview from participants who provided an oral and written consent. The Institutional Review Board (IRB) of the Lebanese University waived the need for ethical approval since this is an observational study with no traceability of subjects. Individuals with learning disabilities or psychiatric disorders were excluded.

Sample size

Sample size was initially calculated to measure the prevalence of cardiovascular RFs. We used Epi Info™ (Center for Disease Control, Atlanta, GA, USA. Available from: http://wwwn.cdc.gov/epiinfo/). Since no other figure was available, we used the prevalence of hypertension (43.1% among individuals aged ≥50 years) as the reference;⁹ after taking into account a worst acceptable result of ±4% difference with the aforementioned prevalence and a 95% confidence interval (CI) as well as the two-stage sampling design, a minimal sample size of 1,200 was required in a population over 40 years of age.

Data collection

The first section of the questionnaire captured the sociodemographic characteristics of the participants. We also asked about educational level, income, and the number of people per household to evaluate the economic situation of participants. This was followed by a second section where information about the presence of CHD was collected. Then, the presence of the main CHD RFs was assessed.

Measurements

Anthropometric measurements included weight (in kg), height (in m), and waist circumference (WC) (in cm). Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured twice following a standardized protocol using an electronic automatic validated device, the Omron^® M6 Comfort (Omron^®, Kyoto, Japan).¹⁰ Random capillary blood glucose (RCBG) was also measured using Accu-Check^® Performa (Roche Diagnostics GmbH, Mannheim, Germany). All measurements were performed by trained medical students. The body mass index (BMI) was then calculated by dividing weight in kilograms by height in meters squared, and was divided into three categories: normal weight (BMI <25 kg/m²), overweight (25 kg/m² ≤ BMI < 30 kg/m²), and obese (BMI ≥30 kg/m²).

CHD definitions

Participants who reported having suffered from a previous MI or having had percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) were considered MI-, PCI-, or CABG-positive, respectively. Angina was defined using the “definite angina” definition of the Rosa Angina Questionnaire.¹¹ To establish the lifetime prevalence of a CHD, prevalence of MI, angina pectoris, PCI, or CABG was summarized.

Behavioral RF definitions

To capture insufficient physical activity, type and frequency of exercise were self-reported. For each activity, we assigned the corresponding metabolic equivalent (MET) value, then a categorization into light-intensity (1.6–2.9 METs), moderate-intensity (3–5.9 METs), and vigorous-intensity (≥6 METs) activities was done based on the updated Compendium of Physical Activities.¹² Insufficient physical activity was defined based on the World Health Organization (WHO) recommendations as less than 150 minutes of light- or moderate-intensity exercise/week and less than 75 minutes of vigorous-intensity exercise/week.¹³ Current smokers were defined as individuals who smoked cigarette and/or waterpipe in the previous 12 months and those who had quit within the past year. Partici pants who had quit more than a year earlier were considered former smokers.¹⁴ For ever-smokers, cumulative dosing of cigarettes was calculated as the average number of daily packs multiplied by the corresponding duration of smoking (pack × years), while that of waterpipe was calculated as the mean number of weekly waterpipes multiplied by the duration of smoking (waterpipe × years).¹⁵ To assess psychological distress, we used a scale that was developed and validated in Lebanon, the Beirut Distress Scale (BDS-22). Possible scores range from 0 to 66 (maximum psychological distress).¹⁶ Dietary habits were assessed using the Lebanese Mediterranean Diet Score, a dietary intake questionnaire for the quantitative estimation of adherence to a Mediterranean diet (MD) adapted to the Lebanese context, ranging from 0 to 52 (maximal adherence).¹⁷

Biological RF definitions

Hypertension was defined as having an average SBP of ≥140 mmHg or an average DBP of ≥90 mmHg or as current use of blood pressure-lowering medication.¹⁸ People who reported having hypertension were also considered hypertensive.¹⁴ Diabetes was defined as the composite of self-reported diabetes, RCBG >11.11 mmol/L, or self-reported medication use for glucose control.¹⁹ Participants were asked if they suffered from hypercholesterolemia or hypertriglyceridemia. Their answers were double-checked with laboratory test results or medication when available. A family history of premature cardiovascular disease (CVD) was defined as a first-degree relative having manifested any CVD before the age of 55 years for males and 65 years for females.^20,21

Statistical analysis

Two independent observers double-checked the quality of the questionnaires; an additional audit was performed on a randomized 5% of the questionnaires. To adjust for the Lebanese population, we performed weighting based on the figures published by the Lebanese Ministry of Social Affairs and the Central Administration of Statistics, taking into account sex, age, and dwelling region.²² Age standardization was then done using the WHO standard population.²³ All analyses were done using SPSS, version 21·0 (IBM Corporation, Armonk, NY, USA). Cluster effect was taken into account, according to the method described by Rumeau-Rouquette et al,²⁴ and we used the SPSS features that take into account this sampling design. Participants with missing information concerning the presence of CHD were removed from the analysis. For normally distributed data, description was done using the mean and standard deviation (SD), while Student’s t-test was used to compare mean between two groups and more than two groups, respectively. For continuous data that were not normally distributed, the median and the interquartile range were used for description, and the Mann–Whitney test was used for comparison. As for categorical variables, we used percentages with 95% CIs and the Pearson chi-square test. P-trends were calculated to measure the prevalence trends across the different age groups. A bivariate analysis measuring the association of the different sociodemographic characteristics, and behavioral and biological RFs with the presence or absence of CHD was done. We then performed multivariate analyses using logistic regression models only including selected variables, all of which had a P-value ≤0.2 in the bivariate analysis. A P-value ≤0.05 was considered statistically significant.

Results

The demographic characteristics of the sample are shown in Table 1.

Table 1 Characteristics of the study participants

Characteristics	Study participants (n=1,362)
Age, in years, median (IQR)	54 (46–65)
Age groups
40–50 years	506 (37.2)
50–60 years	351 (25.8)
60–70 years	234 (17.2)
≥70 years	270 (19.8)
Sex
≥Males	674 (49.4)
Females	689 (50.6)
Region type
Urban	733 (55.6)
Rural	587 (44.4)
Marital status
Married	1,064 (78.6)
Single/widowed/divorced	290 (21.4)
Work status
Working	704 (51.7)
Not working	539 (39.6)
Retired	118 (8.7)
Education level
Complementary level or less	678 (50.3)
Secondary level or more	671 (49.7)
Income for each person of the household (in Lebanese pounds), median ± (IQR)	375,000 (187,500–750,000)

Note: Data are presented as n (percentage) unless indicated otherwise.

Abbreviation: IQR, interquartile range.

Prevalence of CHD

CHD prevalences adjusted to the Lebanese population are presented in Table 2. The overall prevalence of MI, angina, PCI, and CABG was 6% (4.9–7.4), 5.7% (4.6–7.0), 6.6% (5.4–8.1), and 3.9% (3.0–5.0), respectively. These prevalences were markedly different based on the sex of the person, males being more prone to CHD in general. However, in the age group of 70+, the differences in prevalence between sexes were insignifi-cant. Without stratifying by sex, an increase in prevalence was observed with advancing age for all CHD (all P-trend values were <0.05). The lifetime prevalence of MI ranged from 2.9% (1.8–4.7) in 40–49-year-old group to 9.2% (6.4–13.1) in 70+ year-old group. In females, prevalence at 2.2% (1.4–3.5) was less than the quarter of that in males at 10.1% (8.0–12.5) and prevalence was less than 0.4% (0.1–2.0) below age 50. Also, less than 1% of males and females below the age of 50 had undergone a CABG, while almost one in ten in the age of 70+ had done the procedure. In females, prevalence of any CHD at 9.0% (7.1–11.4) was about half as high as that in males (17.8% [15.1–20.9]). Almost one-quarter of Lebanese aged 70+ had at least one manifestation of CHD (Table 2). Figure 1 shows the prevalence of CHD after standardization was done using the WHO world standard population²³ and shows an overall prevalence of 12.3% (10.8–14.1).

Figure 1 Prevalence estimates of CHD, adjusted to the WHO world standard population.

Note: The error bars represent the 95% CI.
Abbreviations: CHD, coronary heart disease; MI, myocardial infarction; PCI, percutaneous coronary intervention; CABG, coronary artery bypass graft; CI, confidence interval; WHO, World Health Organization.

Table 2 Age- and sex-specific CHD prevalence adjusted for the Lebanese population

Coronary heart diseases	40–49 years % (95% CI)	50–59 years % (95% CI)	60–69 years % (95% CI)	≥70 years % (95% CI)	Total % (95% CI)
MI
Male	5.7 (3.4–9.3)	12.8 (8.7–18.4)	12.3 (7.6–19.3)	12.3 (7.9–18.6)	10.1 (8.0–12.5)
Female	0.4 (0.1–2.0)	2.1 (0.8–5.3)	1.7 (0.5–5.9)	6.2 (3.3–11.3)	2.2 (1.4–3.5)
P (χ^2)	<0.001	<0.001	0.001	0.069	<0.001
Overall	2.9 (1.8–4.7)	7.3 (5.0–10.4)	7.0 (4.4–11.0)	9.2 (6.4–13.1)	6.0 (4.9–7.4)
P trend	<0.001
Angina
Male	5.7 (3.4–9.3)	8.4 (5.2–13.2)	11.2 (6.8–17.9)	9.7 (5.8–15.9)	8.2 (6.4–10.5)
Female	1.8 (0.8–4.2)	3.9 (1.9–7.8)	4.0 (1.7–9.1)	4.7 (2.3–9.4)	3.3 (2.2–4.9)
P (χ^2)	0.021	0.071	0.033	0.104	<0.001
Overall	3.7 (2.4–5.7)	6.2 (4.2–9.2)	7.6 (4.9–11.6)	7.1 (4.6–10.7)	5.7 (4.6–7.0)
P trend	0.012
PCI
Male	1.2 (0.4–3.6)	12.3 (8.3–17.9)	17.6 (11.8–25.5)	11.6 (7.4–17.9)	9.2 (7.2–11.6)
Female	1.5 (0.6–3.8)	1.6 (0.6–4.6)	5.0 (2.3–10.6)	11.8 (7.5–18.1)	4.2 (3.0–5.9)
P (χ^2)	0.794	<0.001	0.002	0.966	<0.001
Overall	1.4 (0.7–2.8)	6.8 (4.7–9.9)	11.3 (7.9–16.0)	11.7 (8.5–15.9)	6.6 (5.4–8.1)
P trend	<0.001
CABG
Male	0.8 (0.2–2.9)	6.7 (3.9–11.4)	5.1 (2.4–10.7)	13.7 (9.0–20.2)	5.8 (4.3–7.8)
Female	0	0.5 (0.1–3.0)	3.3 (1.3–8.1)	6.8 (3.6–12.5)	2.0 (1.2–3.3)
P (χ^2)	0.141	0.001	0.476	0.061	<0.001
Overall	0.4 (0.1–1.4)	3.6 (2.1–6.0)	4.1 (2.3–7.5)	10.4 (7.4–14.6)	3.9 (3.0–5.0)
P trend	<0.001
Any CHD
Male	7 (4.4–11.0)	22.7 (17.2–29.5)	22.9 (16.2–31.2)	26.3 (19.6–34.2)	17.8 (15.1–20.9)
Female	3.4 (1.8–6.4)	6.9 (4.0–11.6)	12.0 (7.3–19.1)	20.3 (14.3–27.9)	9.0 (7.1–11.4)
P (χ^2)	0.066	<0.001	0.027	0.246	<0.001
Overall	5.1 (3.5–7.4)	14.8 (11.5–18.9)	17.4 (13.1–22.8)	23.3 (18.7–28.7)	13.4 (11.7–15.3)
P trend	<0.001

Abbreviations: CHD, coronary heart disease; MI, myocardial infarction; PCI, percutaneous coronary intervention; CABG, coronary artery bypass graft; CI, confidence interval.

Association of RFs and CHD

Bivariate analysis

Table 3 shows the distribution of sociodemographic factors, and behavioral and biological RFs for people with and without prevalent CHD. The associated crude odds ratios (ORs) are also presented. CHD was more common with every higher age group. It was also more prevalent in males (OR =2.25, 95% CI =1.62–3.13) and in retired when compared to working subjects (OR =3.59, 95% CI =2.28–5.56). CHD was also more prevalent in participants with a lower education (OR =1.67, 95% CI =1.21–2.30) and with a lower income per person of the household (OR =1.81, 95% CI =1.29–2.53). Regarding risky behaviors, there were more previous smokers in the CHD-positive group (22.4% vs 11.6% in the CHD-free group). Additionally, participants with a lifetime of 30 cigarette-pack-years or more were 2.39 times more likely to be in the CHD group in comparison with nonsmokers. In this study, obesity and abdominal obesity were found to be more common among the CHD group; also, all biological RFs were significantly and markedly more prevalent in the CHD group. The median SBP and RCBG values were higher among subjects with CHD (P<0.001), but the median DBP values were not (P=0.130). No significant differences were found in regard to physical activity, distress, or adherence to an MD.

Table 3 Differences in sociodemographic characteristics, and lifestyle and biological RFs according to coronary heart disease status

Variables	CHD − (n=1179)%	CHD + (n=182)%	P-value	OR (95% CI)	Significance level
Age, in years, median (IQR)	53 (45–63)	61 (54–74)	<0.001	1.04 (1.03–1.06)	*
Age categories			<0.001
40–50 years	40.7	14.3		1
50–60 years	25.4	28.6		3.24 (1.98–5.29)	*
60–70 years	16.4	22.5		3.93 (2.34–6.61)	*
≥70 years	17.6	34.6		5.59 (3.44–9.08)	*
Male (vs female)	46.8	66.5	<0.001	2.25 (1.62–3.13)	*
Rural (vs urban)	43.7	49.4	0.165	1.26 (0.91–1.73)
Single/widowed/divorced (vs married)	21.6	20.6	0.762	0.94 (0.64–1.39)
Work status			<0.001
Working	53.0	43.4		1
Not working	40.1	36.3		1.10 (0.78–1.56)
Retired	6.9	20.3		3.59 (2.28–5.65)	*
Lower than secondary level	48.0	60.7	0.002	1.67 (1.21–2.30)	**
Income/person of the household lower than the first quartile of the sample	25.8	38.6	<0.001	1.81 (1.29–2.53)	*
Smoking status			0.001
Never smoker	39.4	34.1		1
Previous smoker	11.6	22.4		2.19 (1.39–3.45)	*
Current smoker	49.0	43.5		1.01 (0.70–1.46)
Cigarette smoking			<0.001
Non-cigarette smoker	53.5	41.7		1
0.1–14.9 cigarette-pack-years	17.7	13.1		0.94 (0.56–1.56)
15–29.9 cigarette-pack-years	9.3	8.9		1.22 (0.67–2.23)
≥30 cigarette-pack-years	19.5	36.3		2.39 (1.64–3.49)	*
Waterpipe smoking			0.482
Non-waterpipe smoker	80.2	83.6		1
0.1–19.9 WP-years	8.9	5.5		0.57 (0.28–1.17)
20–39.9 WP-years	3.0	3.6		1.25 (0.53–2.95)
≥40 WP-years	7.9	7.3		0.87 (0.46–1.64)
BDS-22, median (IQR)	4.0 (1.0–10.0)	4.0 (1.0–11.7)	0.954	1.01 (1.00–1.03)
LMDS, m ± SD	31.8±4.1	32.5±4.2	0.071	1.04 (1.00–1.08)
Insufficient physical activity	70.9	74.0	0.407	1.17 (0.81–1.68)
BMI, median (IQR)	27.27 (24.34–30.23)	28.37 (25.51–31.46)	0.002	1.05 (1.02–1.08)	**
BMI categories			0.079
Normal weight	30.9	23.0		1
Overweight	42.5	45.4		1.44 (0.97–2.14)
Obese	26.7	31.7		1.61 (1.05–2.47)	***
WC, m ± SD	94.8±15.5	102.0±16.0	<0.001	1.03 (1.02–1.04)	*
Hypertension	39.4	81.3	<0.001	6.69 (4.53–9.89)	*
SBP, median (IQR)	12.75 (11.30–14.00)	13.75 (12.00–14.50)	<0.001	1.15 (1.06–1.24)	*
DBP, median (IQR)	8 (7–8.5)	7.75 (7–8.5)	0.130	0.96 (0.83–1.10)
Diabetes	14.6	42.6	<0.001	4.35 (3.11–6.08)	*
RCBG, median (IQR)	110 (97–131)	126 (102–161.88)	<0.001	1.01 (1.00–1.01)	*
Hypercholesterolemia	24.0	58.7	<0.001	4.50 (3.18–6.38)	*
Hypertriglyceridemia	17.8	44.6	<0.001	3.72 (2.59–5.33)	*
Family history of premature CVD	13.2	21.0	0.006	1.75 (1.17–2.61)	**

Notes:

* ≤0.001,

** ≤0.01,

*** ≤0.05.

Abbreviations: CHD, coronary heart disease; OR, crude odds ratio; CI, confidence interval; IQR, interquartile range; BDS-22, Beirut Distress Scale; LMDS, Lebanese Mediterranean Diet Score; BMI, body mass index; WC, waist circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure; RCBG, random capillary blood glucose; CVD, cardiovascular disease; RFs, risk factors; WP, waterpipe; m, mean; SD, standard deviation.

Multivariate analysis

Three multivariate regressions are shown in Table 4; the first model includes sociodemographic information, the second also adds behavioral RFs, while the third combines the biological RFs with the aforementioned variables. Model 1 shows that participants with CHD were older and more likely to be males, retired, and less advantaged. Model 2 showed the same effect of age, sex, retirement, and income. It also showed that CHD-positive participants were almost twice more likely to have accumulated more than 30 cigarette-pack-years, and more likely to suffer from abdominal obesity. The last model showed the overall profile of participants living with CHD. Age, sex, and economic situation remained significant, but lifestyle factors were replaced by biological factors: hyper-cholesterolemia seemed to have the most prominent effect (adjusted odds ratio [aOR] =5.22, 95% CI =2.99–9.13), followed by hypertension (aOR =2.64, 95% CI =1.36–5.11), having a family history of premature CVD (aOR =2.36, 95% CI =1.18–4.72), and suffering from diabetes (aOR =2.19, 95% CI =1.18–4.07).

Table 4 Profile of patients with prevalent CHD

Variables	Model 1a	Significance level	Model 2b	Significance level	Model 3c	Significance level
	aOR (95% CI)		aOR (95% CI)		aOR (95% CI)
Age, years	1.04 (1.02–1.05)	*	1.04 (1.02–1.06)	*	1.05 (1.02–1.08)	*
Male	2.32 (1.49–3.61)	*	2.23 (1.20–4.15)	**	4.69 (2.49–8.83)	*
Rural vs urban	–		–		–
Work status
Working	1		1		–
Not working	1.10 (0.67–1.81)		1.38 (0.71–2.69)		–
Retired	2.30 (1.37–3.85)	***	2.81 (1.45–5.45)	***	–
Lower than secondary level	–		–		–
Income/person of the household lower than the first quartile of the sample	1.75 (1.21–2.54)	***	1.73 (0.07–2.78)	**	2.21 (1.26–3.90)	***
Cigarette smoking
Non-cigarette smoker			1		–
0.1–14.9 cigarette-pack-years			1.08 (0.55–2.14)		–
15–29.9 cigarette-pack-years			1.09 (0.45–2.63)		–
≥30 cigarette-pack-years			2.02 (1.19–3.44)	***	–
BDS-22			–		–
LMDS			–		–
WC			1.04 (1.02–1.05)	*	–
BMI			–		–
Hypertension					2.64 (1.36–5.11)	***
Diabetes					2.19 (1.18–4.05)	**
Hypercholesterolemia					5.20 (2.97–9.07)	*
Hypertriglyceridemia					–
Family history of premature CVD					2.36 (1.18–4.71)	**

Notes:

a Regression Model 1 included sociodemographic factors: age, sex, region type, marital status, work status, education level, income for each person of the household.

b Regression Model 2 included variables entered in Model 1, plus lifestyle factors: cigarette-pack-years, BDS-22, LMDS, WC, BMI.

c Regression Model 3 included variables entered in Model 2, plus biological factors: hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia, family history of premature CVD.

* ≤0.001,

** ≤0.05,

*** ≤0.01.

Abbreviations: CHD, coronary heart disease; aOR, adjusted odds ratio; CI, confidence interval; BDS-22, Beirut Distress Scale; LMDS, Lebanese Mediterranean Diet Score; WC, waist circumference; BMI, body mass index; CVD, cardiovascular disease.

Discussion

This paper is the first to investigate the prevalence of CHD among Lebanese aged 40 years and above, and to examine the association of CHD with sociodemographics, and behavioral and health-related characteristics.

Prevalence of CHD

The prevalence of CHDs increased with age and were markedly more abundant in males. However, significant differences between sexes disappeared with older age. This pattern likely reflects unequal distributions of CVD RFs between sexes up to a certain age. In fact, a trend was noticed in our data of females having lower biological RFs, while this advantage leveled off with age (results not shown), a trend that has been found in larger works.^25–27

Studies measuring the burden of CHD mostly report CHD incidence, whereas only few report CHD prevalence. Also, most studies include different age ranges, and often report only an overall prevalence without the presentation of age-specific rates. The overall prevalence of MI was similar to the one found in Jordanian²⁸ and German studies,²⁹ which measured the prevalence of prior MI in adults over 40. In the German population having a substantially higher proportion of people in the age group of ≥60 years (27.6% vs 11.5% in Lebanon and 5.4% in Jordan),³⁰ the similarity in prevalence rates suggests an earlier onset of CHD in Middle Eastern countries. Furthermore, when comparing age-specific prevalences of MI and angina, prevalences of MI were higher than recent reports from the UK in all age groups for males and females, but angina seemed to be more prevalent in Lebanon in the younger age groups.³¹ On the other hand, when comparing to the prevalences in the USA, Lebanese males had higher MI prevalences until the age of 80.³² This prematurity in the onset of CHD in the Middle East was well established in the INTERHEART study.³³

Association of socioeconomic status and CHD

Age and male sex have long been linked with CHD. In our study, these two variables showed significant results in all multivariate models. Another Lebanese study on the socioeconomic disparities in heart disease also found male sex and older age to be nonmodifiable independent RFs.⁷ Rural and urban living did not seem to influence CHD. This could be explained by the small size of the Lebanese territory, the displacements of the Lebanese population, and modernization. Other studies showed only minor influence of habitat location on self-reported morbidity.³⁴ On the other hand, retirement increased the odds of belonging to the CHD group, even after adjusting for age. In fact, retirement has been linked to an increase in CVD.³⁵ Lower socioeconomic status remained in the multivariate analysis as in other studies from non-Western countries.^7,28,36 The persistence of the income level even after adjustment for the biological RFs suggests an independent effect of socioeconomic status on CHD.

Association of behavioral RFs and CHD

In the bivariate analysis, previous smoking, but not current smoking, was associated with CHD; this was previously seen in another local study⁷ and indicates that the presence of CHD might have been an incentive for smoking cessation. Also, we found that accumulating more than 30 cigarette-pack-years over the years put people more at risk of CHD compared to nonsmokers, but no effect was found in water-pipe smokers. Although waterpipe smoking has been linked to CVD, a Lebanese study showed that heavy waterpipe smoking only increased the odds of having severe stenosis.³⁷ The cigarette’s impact remained significant when entered in the multivariate analysis of behavioral RFs, along with WC, but both disappeared from the model when biological RFs were added, showing that the effects of these lifestyle RFs on CHD were probably mediated through biological RFs. BMI did not persist in the multivariate analysis, although WC did; same results were found in a large study, which concluded that obesity-related health risk is explained by WC.³⁸ Moreover, in the bivariate analysis, better adherence to an MD and higher distress scores were mildly associated with CHD, suggesting a diet modification in CHD patients, and supporting the important role of psychological distress as an RF in the Middle Eastern populations.³⁹

Association of biological RFs and CHD

All biological RFs were strongly associated with CHD in the bivariate analysis. While SBP gave significant results, DBP did not. In fact, systolic hypertension is more common and more strongly associated with cardiovascular complications than diastolic hypertension; it is also more difficult to treat.⁴⁰ This was noticed in our sample where the prevalence of uncontrolled DBP (24.9%, 95% CI =21.9%–27.9%) was significantly lower than that of SBP (43.1%, 95% CI =39.7%–46.5%). Our final multivariate regression model confirms the relevance of the classic biological RFs in Lebanon after adjustment for sociodemographics and lifestyle RFs. They appeared to be strongly associated with CHD except for hypertriglyceridemia; this could be explained by the strong clustering of hypercholesterolemia and hypertriglyceri-demia in our sample. Finally, family history of premature CVD seemed to be an important independent predictor of CHD.⁶

In Lebanon, primary health care centers receive mostly the underprivileged who seem to be more prone to CHD. Our results should thus encourage the incorporation of care managers into the primary health care centers, whose role would be to support physicians in the management of patients with CVD RFs; this intervention is feasible and has proven its efficacy in improving health behaviors and reaching better compliance with care recommendations, consequently improving clinical indicators and achieving better results.⁴¹

The results of this study should be interpreted in light of the following strengths and limitations. The strengths of this study include the generalizability of its conclusions conferred by the sample size and the representativeness of the study sample, making it the first study to report a national estimate for CHD prevalence. Moreover, the questionnaire captured several aspects allowing us to explore the relationship of CHD with demographics, socioeconomics, and behavioral and health-related factors. Nevertheless, the study has some limitations that ought to be reported. The cross-sectional nature of this study limits the assessment of temporality and therefore causality. Nonetheless, a temporal relationship is plausible for associations such as family history, age, sex, and education level. Also, the population-based setting of this study does not allow the measurement of asymptomatic CHD prevalence. Possible misclassification bias could have been introduced since data concerning CHD and most RFs were self-reported. Yet, a previous study suggested the reliability and validity of the reporting of heart disease in the Lebanese population.⁴² Also, the Rosa Angina score was used to determine angina prevalence, and two measurements of BP and one measurement of RCBG were done. Finally, excessive alcohol consumption could not be accounted for in this study as it is believed that alcohol would be largely underreported for religious reasons.

Conclusion

This study was the first nationwide endeavor to investigate CHD prevalence and to construct the profile of Lebanese adults who should be targeted for secondary prevention. CHD seemed to appear more prematurely than in Western populations and seemed to be more prevalent in males. This study also confirms the relevance of the classic RFs of CHD and their applicability to the Lebanese population. Our findings suggest that targeted interventions aiming to reduce these classic RFs should be conducted to decrease the burden of CHD, especially in economically disadvantaged people.

Acknowledgments

The Foundation thanks all employees and students who participated in data collection and implementation of this study, particularly in isolated rural areas despite the political and security situation. Grateful thanks and recognition to Dr Ghada Al Sayed for her involvement and coordination.

The following medical students are acknowledged; Abdel Majid Abdel Kader, Abeer Shbaro, Alaa Mesri, Alamir Noureddine Alayoubi, Ali Ibrahim, Ali Jaafar, Amal Younes, Amani Chahine, Baraah Nachar, Elia Awad, Elias Assaf, Farah Assi, Farah Mansour, Faten Mansouri, Fatima Al Atab, Hasan Farhat, Hasan Joumaa, Hussein Yassin, Iman Jaafar, Imtissal Krayem, Inaam Issa, Issa Harmouche, Joyce Saliba, Khouloud Hassan, Laila Tabash, Lama Labaki, Lama Mortada, Layal Baddour, Liliane Issa, Loujayne Osman, Malak Hasan, Manal Ghandour, Mariam Abboud, Mariam Fakih, Maritta Khawand, Marwa Harakeh, Maryam Sinno, Mhammad Darwich, Mohamad Ayoub, Mohammad Khodor, Mona Fakih, Narjes Jaafar, Norma Dahdah, Nour Labaki, Nour Mahdi, Omar El Mawas, Oula Mesri, Patrick Sarkis, Rana Kandar, Rasheed BouDiab, Richard Bedran, Rima El Baset, Rita Daher, Samar Siblani, Shahah Hashem, Souad BouHarb, Widad Chami, Wissam Yassin, Younes Mahmoud, Youness Hassan, Zainah Majed, Zeina Nasser.

The study was conducted in 60/100 circumscriptions as independent study by the Foundation-Medical Research Institutes (F-MRI^®) as sole sponsor with its own human, technical, and financial supports.

Disclosure

The authors report no conflicts of interest in this work.