Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans

Abstract

Background and Purpose

Cerebral ischemia is a common, morbid condition accompanied by cognitive decline. Recent reports on the vascular health benefits of flavanol-containing foods signify a promising approach to the treatment of cerebral ischemia. Our study was designed to investigate the effects of flavanol-rich cocoa (FRC) consumption on cerebral blood flow in older healthy volunteers.

Methods

We used transcranial Doppler (TCD) ultrasound to measure mean blood flow velocity (MFV) in the middle cerebral artery (MCA) in thirty-four healthy elderly volunteers (72 ± 6 years) in response to the regular intake of FRC or flavanol-poor cocoa (FPC).

Results

In response to two weeks of FRC intake, MFV increased by 8% ± 4% at one week (p = 0.01) and 10% ± 4% (p = 0.04) at two weeks. In response to one week of cocoa, significantly more subjects in the FRC as compared with the FPC group had an increase in their MFV (p < 0.05).

Conclusions

In summary, we show that dietary intake of FRC is associated with a significant increase in cerebral blood flow velocity in the MCA as measured by TCD. Our data suggest a promising role for regular cocoa flavanol’s consumption in the treatment of cerebrovascular ischemic syndromes, including dementias and stroke.

Keywords:

• cerebral blood flow
• flavanol
• cocoa
• transcranial Doppler ultrasound

Acknowledgements

This work was supported in part with a research grant from Mars, Incorporated. Dr. Fisher is supported by RO3 AG023896 and Dr. Lipsitz by AG08812 and AG00439. There are no other conflicts of interest to report.