CYP3A5 and ABCB1 Genes and Hypertension

Abstract

Hypertension is the first single modifiable cause of disease burden worldwide. Genes encoding proteins that are involved in the metabolism (CYP3A5) and transport (ABCB1) of drugs and hormones might contribute to blood pressure control in humans. Indeed, recent data have suggested that CYP3A5 and ABCB1 gene polymorphisms are associated with blood pressure in the rat as well as in humans. Interestingly, the effects of these genes on blood pressure appear to be modified by dietary salt intake. This review summarizes what is known regarding the relationships of the ABCB1 and CYP3A5 genes with blood pressure, and discusses the potential underlying mechanisms of the association. If the role of these genes in blood pressure control is confirmed in other populations and other ethnic groups, these findings would point toward a new pathway for blood pressure control in humans.

KEYWORDS::

• ABCB1
• blood pressure
• CYP3A5
• dietary salt intake
• gene–gene interaction
• hypertension
• renin–angiotensin system

Financial & competing interests disclosure

The authors declare that they have no competing interest. M Bochud is supported by grants from the Swiss National Foundation for Science (PROSPER: 3200BO-111362/1 and 3233BO-111361/1). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

The authors declare that they have no competing interest. M Bochud is supported by grants from the Swiss National Foundation for Science (PROSPER: 3200BO-111362/1 and 3233BO-111361/1). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.