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Pharmacogenomics Volume 6, 2005 - Issue 5
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Review

The Pharmacogenetics of Coumarin Therapy

Deepak Voora1 Washington University School of Medicine, Departments of Medicine and of Pathology, St. Louis, MO, USA
,
Howard L McLeod1 Washington University School of Medicine, Departments of Medicine and of Pathology, St. Louis, MO, USA
,
Charles Eby1 Washington University School of Medicine, Departments of Medicine and of Pathology, St. Louis, MO, USA
&
Brian F Gage1 Washington University School of Medicine, Departments of Medicine and of Pathology, St. Louis, MO, USA;2 Washington University School of Medicine, Division of General Medical Sciences, Campus Box 8005, 660 S. Euclid Ave., St. Louis, MO, 63110, USA.Correspondence[email protected]
Pages 503-513 | Published online: 24 Nov 2005
 
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Abstract

Vitamin K antagonists (coumarins) are widely-used oral anticoagulants for the prevention of venous thromboembolism and strokes. Wide inter-individual variation in dose response and frequent bleeds characterize the initiation of coumarin therapy. Over the past 10 years both genetic and nongenetic determinants of coumarin dose response have been identified. A comprehensive pharmacogenetics approach to warfarin therapy has the potential to improve the safety and efficiency of warfarin initiation.

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