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Aging Health Volume 2, 2006 - Issue 3
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Review

Parkinson’s Disease and Deep Brain Stimulation

Rianne AJ Esselink1 Department of Neurology, Academic Medical Center Amsterdam, PO Box 22660, 1100DDAmsterdam, The Netherlands Tel.: +31 (0)20 5663842; Fax: +31 (0)20 5669374; E-mail: [email protected]@amc.uva.nl;2 Departments of Neurology and Geriatrics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HBNijmegen, The Netherlands. Tel.: +31 (0)24 3618860; Fax: +31 (0)24 3541122; E-mail: [email protected]
,
Rob MA de Bie1 Department of Neurology, Academic Medical Center Amsterdam, PO Box 22660, 1100DDAmsterdam, The Netherlands Tel.: +31 (0)20 5663842; Fax: +31 (0)20 5669374; E-mail: [email protected]@amc.uva.nl
,
P Richard Schuurman3 Department of Neurosurgery, Academic Medical Center Amsterdam, PO Box 22660, 1100DDAmsterdam, The Netherlands Tel.: +31 (0)20 5663542; Fax: +31 (0)20 5669590; E-mail: [email protected]@amc.uva.nl
,
D Andries Bosch3 Department of Neurosurgery, Academic Medical Center Amsterdam, PO Box 22660, 1100DDAmsterdam, The Netherlands Tel.: +31 (0)20 5663542; Fax: +31 (0)20 5669590; E-mail: [email protected]@amc.uva.nl
&
Johannes D Speelman1 Department of Neurology, Academic Medical Center Amsterdam, PO Box 22660, 1100DDAmsterdam, The Netherlands Tel.: +31 (0)20 5663842; Fax: +31 (0)20 5669374; E-mail: [email protected]@amc.uva.nl
Pages 473-487 | Published online: 24 May 2006
 

Abstract

Patients with advanced Parkinson‘s disease are often disabled by response fluctuations and dyskinesias despite optimal pharmacological treatment. Bilateral deep brain stimulation of the subthalamic nucleus or the internal part of the globus pallidus can lead to a substantial reduction of these motor symptoms and thereby improve functioning in activities of daily living. This article aims to review some general aspects of Parkinson’s disease, the history of surgery for Parkinson’s disease, and the effects, adverse events, indications and contraindications of deep brain stimulation in advanced Parkinson’s disease.

Conflicts of interest

Johannes D Speelman acts as an independent consultant for Medtronic Ltd. (MN, USA). An unrestricted research grant was received from Medtronic Ltd. for the work group on Movement Disorders at the Academic Medical Center, University of Amsterdam. Rianne AJ Esselink, Rob MA de Bie, and Speelman received travel grants from Medtronic Ltd. to participate in scientific meetings.

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