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Regenerative Medicine Volume 1, 2006 - Issue 4
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Special Focus: Mesenchymal Stem Cells – Review

Engineering Stem Cells for Therapy

Marinela Mendez-Pertuz1 Bone and Joint Research Unit, Barts and The London Queen Mary's School of Medicine and Dentistry, University of London, Charterhouse Square, LondonEC1M 6BQ, UK. +44 20 7882 6122; Fax: +44 20 7882 6121;[email protected]
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Chris Hughes1 Bone and Joint Research Unit, Barts and The London Queen Mary's School of Medicine and Dentistry, University of London, Charterhouse Square, LondonEC1M 6BQ, UK. +44 20 7882 6122; Fax: +44 20 7882 6121;[email protected]
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Alex Annenkov1 Bone and Joint Research Unit, Barts and The London Queen Mary's School of Medicine and Dentistry, University of London, Charterhouse Square, LondonEC1M 6BQ, UK. +44 20 7882 6122; Fax: +44 20 7882 6121;[email protected]
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Gordon Daly1 Bone and Joint Research Unit, Barts and The London Queen Mary's School of Medicine and Dentistry, University of London, Charterhouse Square, LondonEC1M 6BQ, UK. +44 20 7882 6122; Fax: +44 20 7882 6121;[email protected]
&
Yuti Chernajovsky1 Bone and Joint Research Unit, Barts and The London Queen Mary's School of Medicine and Dentistry, University of London, Charterhouse Square, LondonEC1M 6BQ, UK. +44 20 7882 6122; Fax: +44 20 7882 6121;[email protected]
Pages 575-587 | Published online: 18 Jul 2006
 
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Abstract

The differentiation of a stem cell is dependent on the environmental cues that it receives and can be modulated by the expression of different master regulators or by secreted factors or inducers. The use of genetically modified stem cells to express the required factors can direct differentiation along the requisite pathway. This approach to the engineering of stem cells is important, as control of the pluripotentiality of stem cells is necessary in order to avoid unwanted growth, migration or differentiation to nontarget tissues. The authors provide an overview of the stem cell engineering field, highlighting challenges and solutions, and focusing on recent developments in therapeutic applications in areas such as autoimmunity, CNS lesions, bone and joint diseases, cancer and myocardial infarction.

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