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Abstract
Evaluation of: HBV, HCV and TTV detection by in situ polymerase chain reaction could reveal occult HCV infection in hepatocellular carcinoma: comparison with blood markers. J. Clin. Pathol. 59, 526–529 (2006). Occult hepatitis B virus (HBV) and occult hepatitis C virus (HCV) infections are characterized by lack of virological serum markers of infection with intrahepatic presence of the viral genome. These occult infections have been detected in chronic hepatitis or cirrhosis of unknown etiology. Moreover, occult HBV infection is recognized as a risk factor for the development of hepatocellular carcinoma, but the possible pathogenic role of occult HCV infection in this malignancy has not been studied. Comar and colleagues have retrospectively analyzed the presence of HBV and HCV genomes in eight hepatocellular carcinoma tissues, finding occult HBV and occult HCV infections in one and two cancerous liver tissues, respectively. This study provides evidence for the existence of occult HCV infection in the development of certain cases of hepatocellular carcinoma of unexplained origin.