Recombinant Newcastle Disease Virus-Vectored Vaccines Against Human and Animal Infectious Diseases

Abstract

Recent advances in recombinant genetic engineering techniques have brought forward a leap in designing new vaccines in modern medicine. One attractive strategy is the application of reverse genetics technology to make recombinant Newcastle disease virus (rNDV) deliver protective antigens of pathogens. In recent years, numerous studies have demonstrated that rNDV-vectored vaccines can induce quicker and better humoral and mucosal immune responses than conventional vaccines and are protective against pathogen challenges. With deeper understanding of NDV molecular biology, it is feasible to develop gene-modified rNDV vaccines accompanied by good safety, high efficacy, low toxicity and better immunogenicity. This review summarizes the development of reverse genetics technology in using NDV as a promising vaccine vector to design new vaccines for human and animal use.

KEYWORDS:

• Newcastle disease virus
• protective immune response
• reverse genetics technology
• vaccine development
• virus-vectored vaccine

Financial & competing interests disclosure

The authors were funded by the Scientific Research Cooperation with America and Oceania Region, Ministry of Education (JWSM-2014-2029), the Guizhou Province-School Cooperation Project (QKH-LHZ-2014-7669) and the Scientific Research Project of Guizhou University Talents Fund (GDRJHZ-2014-10). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

The authors were funded by the Scientific Research Cooperation with America and Oceania Region, Ministry of Education (JWSM-2014-2029), the Guizhou Province-School Cooperation Project (QKH-LHZ-2014-7669) and the Scientific Research Project of Guizhou University Talents Fund (GDRJHZ-2014-10). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.