Abstract
Paget‘s disease of bone is a disorder of focal bone remodeling that occurs in the adult skeleton, and that increases in prevalence with aging. The natural history of Paget‘s disease of bone is the progression of bony overgrowth and deformity, with most complications arising from these ‘…changes of shape, size and direction of the diseased bones’ (Sir James Paget 1877). There has been considerable interest in the morbidity and mortality of patients with Paget‘s disease of bone, and studies addressing these issues, as well as the evaluation and treatment of Paget‘s disease, will be the focus of this review. A brief review of the epidemiology and a case study will be used to illustrate specific issues arising in the evaluation and treatment of patients with Paget‘s disease of bone.
Financial & competing interests disclosure
The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.