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Review

Neural Markers and Implantable Bioelectronic Systems for the Treatment of Hypertension

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Pages 139-150 | Received 23 Nov 2017, Accepted 11 Jan 2018, Published online: 25 May 2018
 

Abstract

Present bioelectronic devices for the treatment of resistant hypertension are based on electric stimulation of the carotid baroreceptors. Left vagus nerve (LVN) stimulation, to modulate the aortic baroreceptor signals has received less attention. Undeservedly so, since the aortic baroreceptors have a central role in the blood pressure (BP) control. Moreover, from the same site at the LVN where the stimulation is applied, a nerve signal can be recorded as well. This nerve signal mimics the BP in the aortic arch and mirrors the respiratory activity. As such, this signal could be used in a closed-loop LVN stimulation system to monitor the BP and physical activity as needed for safety and efficacy of any BP control system.

Financial & competing interests disclosure

No funding for this work was received from any sources. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

No funding for this work was received from any sources. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.

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