The Diagnostic Role of Circulating Inflammation-Based Biomarker in Gallbladder Carcinoma

Abstract

Aim

To investigate the diagnostic roles of circulating inflammatory biomarkers in gallbladder carcinoma (GBC).

Patients & methods

Circulating inflammatory cell count, fibrinogen, albumin, carcinoembryonic antigen (CEA) and CA199 were measured, neutrophil-to-lymphocyte ratio (NLR), dNLR, PLR, LMR and Alb-to-fib (AFR) were calculated in 306 GBC patients, 306 healthy and 305 benign controls. The reciever operating characteristic curve was used to determine diagnostic accuracy of them.

Results

The area under curves of combined AFR, dNLR and lymphocyte were 0.943 and 0.985 for diagnosis of GBC from healthy and polyp controls, area under curve of combined AFR, CEA and CA199 was 0.90 for diagnosis of GBC from the cholecystitis patients.

Conclusion

Circulating AFR combined with lymphocyte and dNLR or CEA and CA199 could effectively distinguish GBC from the healthy and benign controls.

Keywords::

• AFR
• biomarker
• dNLR
• gallbladder carcinoma
• inflammation
• lymphocyte

Ethical disclosure

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Author’s contributions

HQ Ying and XZ Wang contributed to the study, concept and design and supervised the project. XF Liu performed most of the experiments, undertook the statistical analysis and wrote the draft of the manuscript. LY Zhou participated in parts of the experiments. ZH Wei, JX Liu and A Li participated in the sample collection. All authors read and approved the final version of the manuscript.

Financial & competing interests disclosure

This report was supported by the National Natural Science Foundation of China (grant numbers 81360083 and 81702090), the Natural Science Youth Foundation of Jiangxi Province (grant number 20171BAB215054) and the Key Technology Research and Development Program of Jiangxi Province (grant number 20071BBG70049). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This report was supported by the National Natural Science Foundation of China (grant numbers 81360083 and 81702090), the Natural Science Youth Foundation of Jiangxi Province (grant number 20171BAB215054) and the Key Technology Research and Development Program of Jiangxi Province (grant number 20071BBG70049). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.