Circulating Bone-Specific Alkaline Phosphatase and Abdominal Aortic Calcification in Maintenance Hemodialysis Patients

Abstract

Aim: To explore the relationship between circulating bone-specific alkaline phosphatase (BALP) levels and abdominal aortic calcification (AAC) in patients receiving maintenance hemodialysis (MHD). Methods: A total of 156 MHD patients were enrolled. Serum BALP levels were measured using ELISA, and AAC was assessed via lateral abdominal radiography. Results: BALP was positively correlated with AAC score (r = 0.389; p < 0.01). Multivariate logistic regression analysis showed that high-sensitivity C-reactive protein, dialysis vintage and BALP were independent risk factors for AAC in MHD patients. Receiver-operating characteristic analysis indicated that the area under the curve of BALP for the prediction of AAC was 0.737 (95% CI: 0.619–0.855; p < 0.01). When the detection cut-off level was 17.55 μg/l, its sensitivity was 81.7% and specificity was 74.5%. Conclusion: Serum BALP is closely correlated with vascular calcification in MHD patients.

Keywords: :

• abdominal aortic calcification
• alkaline phosphatase
• atherosclerosis
• bone-specific alkaline phosphatase
• cardiovascular disease
• chronic kidney disease
• hemodialysis
• lateral abdominal radiography
• mineral and bone disorder
• vascular calcification

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved. The study was carried out in accordance with the tenets of the Helsinki Declaration and was approved by the Ethics Committee of Renji Hospital.