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Abstract
Aim
We investigated the relationship between NT-ProBNP and mortality in a general population-based cohort.
Methods & Results
A total of 2021 out of 4650 participants from previously published HAPPY study were included. Mean follow-up was 84.5 ± 10.4 months. After adjusting for risk factors, high levels of LogNT-proBNP predicted all-cause death (HR: 3.23; 95% CI: 2.20–4.75; p < 0.001) and cardiovascular death (HR: 3.85; 95% CI: 2.37–6.26; p < 0.001). Regression analysis revealed that LogNT-proBNP was an independent predictor of all-cause death (HR: 2.85; 95% CI: 1.91–4.24; p < 0.001) and cardiovascular death (HR: 3.02; 95% CI: 1.84–4.95; p < 0.001).
Conclusıon
Our study showed that in long term follow-up, NT-proBNP is associated with increased all-cause and cardiovascular mortality
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.