Inflammation Level and Renal Function Injury in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Correlation with Low Albumin and High-Density Lipoprotein

Abstract

Aim: To explore the correlation of inflammation level and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis (AAV) patients with Alb and HDL. Materials & methods: Serum levels of Alb and HDL were measured, with AAV patients being grouped according to serum Alb and HDL levels, and indicators reflecting inflammation and renal injury were compared. Results: Serum levels of creatinine (Cr), uric acid and CRP and renal involvement rates were higher in lower Alb patients; Cr, CRP, renal and cardiovascular involvement rates in lower HDL patients were higher. Alb and HDL were negatively correlated with CRP and erythrocyte sedimentation rate. Conclusion: Serum Alb and HDL were good indictors for disease monitoring in AAV.

Keywords:

• albumin
• ANCA associated vasculitis
• antineutrophil cytoplasmic antibody
• C-reactive protein
• creatinine
• erythrocyte sedimentation rate
• estimated glomerular filtration rate
• high-density lipoprotein
• organ involvement
• uric acid

Author contributions

T Zeng and L Tan conceived and designed the experiments. T Zeng and Y Tian performed the experiments and analyzed the data. Y Wu, J Yu, J Huang and Z Pei collected samples and patients’ information. Y Tian and T Zeng prepared the manuscript.

Financial & competing interests disclosure

The authors thank for kind supports from the National Nature Science Foundation of China under grant 81760382; grants from Jiangxi Provincial Science and Technology Bureau under grant 20151122070198; and the Innovation Special Fund for postgraduates of Nanchang University. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

This study was in accordance with the 1964 Helsinki declaration as well as its later amendments, and obtained the approval from Ethics Committee of the Second Affiliated Hospital of Nanchang University with written informed consents obtained from all eligible participants.

Additional information

Funding

The authors thank for kind supports from the National Nature Science Foundation of China under grant 81760382; grants from Jiangxi Provincial Science and Technology Bureau under grant 20151122070198; and the Innovation Special Fund for postgraduates of Nanchang University. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.