Preoperative Ca125 Value Predicts Glisson Capsule Involvement in Patients with Peritoneal Carcinomatosis Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Abstract

Aim: The difficulty of detecting lesions smaller than 1 cm in the preoperative period is still a continuing problem in peritoneal carcinomatosis. Methods: The prospective data of 106 peritoneal carcinomatosis patients were included this study. Preoperative AFP, carcinoembryonic antigen, CA19.9, CA125, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet value, platelet distribution width, red cell distribution width and radiological findings compared according to Glisson capsule tumor involvement. Results: Preoperative radiological imaging methods have low accuracy in demonstrating Glisson capsule involvement. Inflammatory and serum tumor markers, except CA125, have been shown to be ineffective at detecting preoperative Glisson capsule involvement. CA125 levels higher than 52.4 were found to be significant in indicating Glisson's capsule involvement. Conclusion: CA125 is more sensitive than radiological and nuclear imaging methods in detecting tumors smaller than 1 cm.

Keywords:

• CA125
• CEA
• cytoreductive surgery
• Glisson capsule
• hyperthermic intraperitoneal chemotherapy (HIPEC)
• neutrophil/lymphocyte ratio
• platelet/lymphocyte ratio

Author contributions

Literature search was done by IS Sarici, O Duzgun. Data collection was done by O Duzgun, IS Sarici. Study design and review of manuscript were done by IS Sarici and O Duzgun.

Analysis of data and manuscript preparation were done by O Duzgun and IS Sarici.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

This paper was edited by Elsevier Language Editing Services.

Ethical conduct of research

Ethical approval was obtained (2018/150) for the study from the ethics committee of University of Health Sciences Umraniye Training and Research Hospital.